AIM:To elucidate the associations of iris color with major eye diseases.· METHODS:A systematic search on Medline with coverage up to August 2013 was conducted. Assessment of the quality of studies based on their ...AIM:To elucidate the associations of iris color with major eye diseases.· METHODS:A systematic search on Medline with coverage up to August 2013 was conducted. Assessment of the quality of studies based on their levels of evidence was in accordance with the Centre for Evidence-Based Medicine, Oxford, United Kingdom.RESULTS:A relationship between darker iris color and an increased risk of age-related cataract has been reported from cross-sectional studies and prospective cohort studies. There was no consistent evidence supporting a major role of iris color in the development or progression of age-related macular degeneration. The association of iris color with ocular uveal melanoma has been confirmed by a meta-analysis of observational studies previously. The etiologic synergism between light iris color and environmental exposure such as UV the exposure of UV radiation was found. There were no studies evaluating the refractive associations with iris color but there may be a possible link between iris color and myopia.CONCLUSION:Darker iris color is associated with an increased risk of cataract and a reduced risk of ocular uveal melanoma. The association of iris color with agerelated macular degeneration is not confirmed.Ophthalmologists should be aware that the risk of ocular disorders appears to vary by differences in iris color.展开更多
Summary What is already known about this topic?Previously,it has been proved that a simplified model that uses refraction error value provides a robust and efficient means of predicting myopia for non-myopic students....Summary What is already known about this topic?Previously,it has been proved that a simplified model that uses refraction error value provides a robust and efficient means of predicting myopia for non-myopic students.Intervention targeting non-myopic children with alert refraction errors(or insufficient hyperopia reserve)holds significant importance in reducing the incidence rate of myopia.What is added by this report?This study,comprising two phases(surveillance and cohort studies),was aiming to pinpoint the precise refractive error value for the onset of myopia prediction among non-myopic children in Jiangsu Province.What are the implications for public health practice?First,when conducting myopia screenings using pupil dilation for non-myopic populations:the cycloplegic 50th percentile refractive error emerges as a more precise predictive indicator.Second,when conducting myopia screenings without pupil dilation:this study advocates for the incorporation of axial length(AL)and corneal curvature(CC)values as supplementary indicators in screenings.展开更多
基金Supported by the China Postdoctoral Science Foundation(No.2013M531405)
文摘AIM:To elucidate the associations of iris color with major eye diseases.· METHODS:A systematic search on Medline with coverage up to August 2013 was conducted. Assessment of the quality of studies based on their levels of evidence was in accordance with the Centre for Evidence-Based Medicine, Oxford, United Kingdom.RESULTS:A relationship between darker iris color and an increased risk of age-related cataract has been reported from cross-sectional studies and prospective cohort studies. There was no consistent evidence supporting a major role of iris color in the development or progression of age-related macular degeneration. The association of iris color with ocular uveal melanoma has been confirmed by a meta-analysis of observational studies previously. The etiologic synergism between light iris color and environmental exposure such as UV the exposure of UV radiation was found. There were no studies evaluating the refractive associations with iris color but there may be a possible link between iris color and myopia.CONCLUSION:Darker iris color is associated with an increased risk of cataract and a reduced risk of ocular uveal melanoma. The association of iris color with agerelated macular degeneration is not confirmed.Ophthalmologists should be aware that the risk of ocular disorders appears to vary by differences in iris color.
基金Jiangsu Provincial Science and Technology Resource Coordination Service Platform for open research project(TC2022B023).
文摘Summary What is already known about this topic?Previously,it has been proved that a simplified model that uses refraction error value provides a robust and efficient means of predicting myopia for non-myopic students.Intervention targeting non-myopic children with alert refraction errors(or insufficient hyperopia reserve)holds significant importance in reducing the incidence rate of myopia.What is added by this report?This study,comprising two phases(surveillance and cohort studies),was aiming to pinpoint the precise refractive error value for the onset of myopia prediction among non-myopic children in Jiangsu Province.What are the implications for public health practice?First,when conducting myopia screenings using pupil dilation for non-myopic populations:the cycloplegic 50th percentile refractive error emerges as a more precise predictive indicator.Second,when conducting myopia screenings without pupil dilation:this study advocates for the incorporation of axial length(AL)and corneal curvature(CC)values as supplementary indicators in screenings.
