Epithelial-mesenchymal transition is a well-defined,reversible process in which epithelial cells lose their epithelial phenotype and acquire mesenchymal-like features.Epithelial-mesenchymal transition contributes sign...Epithelial-mesenchymal transition is a well-defined,reversible process in which epithelial cells lose their epithelial phenotype and acquire mesenchymal-like features.Epithelial-mesenchymal transition contributes significantly to the metastasis,invasion,and development of treatment resistance in cancer cells.There have been many studies on suppression of tumor epithelial-mesenchymal transition by Chinese medicine in recent years,mainly based on Chinese herbal drug monomers and compounds.In this review,we aim to describe the research progress on Chinese medicine in the t ransforming growth factor beta(T GF-β)sig naling pathway,we hope these will provide some guidance for further research on Chinese medicine targeting epithelial-mesenchymal transition.展开更多
Gastric cancer is the second leading cause of cancer mortality worldwide.The diagnosis of gastric cancer has been significantly improved with the broad availability of gastrointestinal endoscopy.Effective technologies...Gastric cancer is the second leading cause of cancer mortality worldwide.The diagnosis of gastric cancer has been significantly improved with the broad availability of gastrointestinal endoscopy.Effective technologies for accurate staging and quantitative evaluation are still in demand to merit reasonable treatment and better prognosis for the patients presented with advanced disease.Preoperative staging using conventional imaging tools,such as computed tomography(CT)and endoscopic ultrasonography,is inadequate.Positron emission tomography(PET),using 18F-fluorodeoxyglucose(FDG)as a tracer and integrating CT for anatomic localization,holds a promise to detect unsuspected metastasis and has been extensively used in a variety of malignancies.However,the value of FDG PET/CT in diagnosis and evaluation of gastric cancer is still controversial.This article reviews the current literature in diagnosis,staging,response evaluation,and relapse monitoring of gastric cancer,and discusses the current understanding,improvement,and future prospects in this area.展开更多
Purpose:Previous studies have confirmed that Achilles tendon occurs Achilles thickening after repair surgery of the rupture.Although this mechanism has been elucidated in the laboratory,there are few reports on its im...Purpose:Previous studies have confirmed that Achilles tendon occurs Achilles thickening after repair surgery of the rupture.Although this mechanism has been elucidated in the laboratory,there are few reports on its impact on clinical function.We designed a retrospective study to investigate the Achilles thickening after Achilles tendon rupture repair and its correlation between the elasticity and postoperative function.Methods:In this retrospective analysis,patients who underwent surgical treatment for acute Achilles tendon rupture from April 2016 to April 2020 were included.All the patients were regularly followed up at 3 months,1 year,and 2 years after surgery.American Orthopaedic Foot Ankle Surgeon(AOFAS)scale and Leppilahti score were used to evaluate functional outcomes.Achilles elasticity was measured by ultrasound shear wave of elasticity.Achilles thickening was calculated as maximal transverse and longitudinal diameter in cross-sectional plane of magnetic resonance scan.Sample t-tests was used for different follow-up periods.Correlation between Achilles thickening and other factors were analyzed using Pearson's method.p<0.05 indicates a statistically significant difference.Results:AOFAS scale and Leppilahti score at 1 year were significantly higher than at 3 months postoperatively(both p<0.001).These functional scales were also improved at 2-year follow-up significantly(both p<0.001).The dorsiflexion difference showed gradually recovery in each follow-up period(t=-17.907,p<0.001).The elasticity of the Achilles appeared to continuously decreases during the postoperative follow-up period in all position sets(p<0.001).In thickening evaluation,the cross-sectional area of the thickest plane of Achilles was significantly higher at 1 year postoperatively(310.5±25.2)mm^(2)than that at 3 months postoperatively((278.0±26.2)mm^(2),t=-8.219,p<0.001)and became thinner in 2-year magnetic resonance scan((256.1±15.1)mm^(2),t=16.769,p<0.001).The correlations between Achilles thickening,elasticity,and functional outcome did not show statistical significance(p>0.05)in every follow-up period.Conclusion:Achilles tendon thickens after surgery in the 1st year,but begins to gradually return to thinning about 2 years after surgery.There was no significant correlation between the increase and decrease of thickening and the patients'clinical function scores,Achilles elasticity,and bilateral ankle dorsiflexion difference.展开更多
基金supported by the Science and Technology Project of Hebei Education Department(QN2018060)Hebei Natural Science Foundation(H2022209027)+2 种基金Tangshan Science and Technology Project(21130230C)and Tangshan Talent Funding Project(A202203021)the Central Government Guides Local Funds For Science a nd Technology Development(Free Exploration o f Basic Research):the synergistic effect of nuclear targeted PTX/CUR nanodelivery system combined photothermal/photodynamic on breast cancer(236Z2704G)Natural Science Foundation of Hebei Province(H2022209068).
文摘Epithelial-mesenchymal transition is a well-defined,reversible process in which epithelial cells lose their epithelial phenotype and acquire mesenchymal-like features.Epithelial-mesenchymal transition contributes significantly to the metastasis,invasion,and development of treatment resistance in cancer cells.There have been many studies on suppression of tumor epithelial-mesenchymal transition by Chinese medicine in recent years,mainly based on Chinese herbal drug monomers and compounds.In this review,we aim to describe the research progress on Chinese medicine in the t ransforming growth factor beta(T GF-β)sig naling pathway,we hope these will provide some guidance for further research on Chinese medicine targeting epithelial-mesenchymal transition.
文摘Gastric cancer is the second leading cause of cancer mortality worldwide.The diagnosis of gastric cancer has been significantly improved with the broad availability of gastrointestinal endoscopy.Effective technologies for accurate staging and quantitative evaluation are still in demand to merit reasonable treatment and better prognosis for the patients presented with advanced disease.Preoperative staging using conventional imaging tools,such as computed tomography(CT)and endoscopic ultrasonography,is inadequate.Positron emission tomography(PET),using 18F-fluorodeoxyglucose(FDG)as a tracer and integrating CT for anatomic localization,holds a promise to detect unsuspected metastasis and has been extensively used in a variety of malignancies.However,the value of FDG PET/CT in diagnosis and evaluation of gastric cancer is still controversial.This article reviews the current literature in diagnosis,staging,response evaluation,and relapse monitoring of gastric cancer,and discusses the current understanding,improvement,and future prospects in this area.
基金This study was supported by grants from Sanming Project of Medicine in Shenzhen(SZSM201612078)Clinical research project of Peking University Shenzhen Hospital(LCYJ2021028).
文摘Purpose:Previous studies have confirmed that Achilles tendon occurs Achilles thickening after repair surgery of the rupture.Although this mechanism has been elucidated in the laboratory,there are few reports on its impact on clinical function.We designed a retrospective study to investigate the Achilles thickening after Achilles tendon rupture repair and its correlation between the elasticity and postoperative function.Methods:In this retrospective analysis,patients who underwent surgical treatment for acute Achilles tendon rupture from April 2016 to April 2020 were included.All the patients were regularly followed up at 3 months,1 year,and 2 years after surgery.American Orthopaedic Foot Ankle Surgeon(AOFAS)scale and Leppilahti score were used to evaluate functional outcomes.Achilles elasticity was measured by ultrasound shear wave of elasticity.Achilles thickening was calculated as maximal transverse and longitudinal diameter in cross-sectional plane of magnetic resonance scan.Sample t-tests was used for different follow-up periods.Correlation between Achilles thickening and other factors were analyzed using Pearson's method.p<0.05 indicates a statistically significant difference.Results:AOFAS scale and Leppilahti score at 1 year were significantly higher than at 3 months postoperatively(both p<0.001).These functional scales were also improved at 2-year follow-up significantly(both p<0.001).The dorsiflexion difference showed gradually recovery in each follow-up period(t=-17.907,p<0.001).The elasticity of the Achilles appeared to continuously decreases during the postoperative follow-up period in all position sets(p<0.001).In thickening evaluation,the cross-sectional area of the thickest plane of Achilles was significantly higher at 1 year postoperatively(310.5±25.2)mm^(2)than that at 3 months postoperatively((278.0±26.2)mm^(2),t=-8.219,p<0.001)and became thinner in 2-year magnetic resonance scan((256.1±15.1)mm^(2),t=16.769,p<0.001).The correlations between Achilles thickening,elasticity,and functional outcome did not show statistical significance(p>0.05)in every follow-up period.Conclusion:Achilles tendon thickens after surgery in the 1st year,but begins to gradually return to thinning about 2 years after surgery.There was no significant correlation between the increase and decrease of thickening and the patients'clinical function scores,Achilles elasticity,and bilateral ankle dorsiflexion difference.
