Anatomic resection improved the long-term outcome of hepatocellular carcinoma patients with microvascular invasion:A prospective cohort study

BACKGROUND The long-term effect of anatomic resection(AR)is better than that of nonanatomic resection(NAR).At present,there is no study on microvascular invasion(MVI)and liver resection types.AIM To explore whether AR improves long-term survival in patients with hepatocellular carcinoma(HCC)by removing the peritumoral MVI.METHODS A total of 217 patients diagnosed with HCC were enrolled in the study.The surgical margin was routinely measured.According to the stratification of different tumor diameters,patients were divided into the following groups:≤2 cm group,2-5 cm group,and>5 cm group.RESULTS In the 2-5 cm diameter group,the overall survival(OS)of MVI positive patients was significantly better than that of MVI negative patients(P=0.031).For the MVI positive patients,there was a statistically significant difference between AR and NAR(P=0.027).AR leads to a wider surgical margin than NAR(2.0±2.3 cm vs 0.7±0.5 cm,P<0.001).In the groups with tumor diameters<2 cm,both AR and NAR can obtain a wide surgical margin,and the surgical margins of AR are wider than that of NAR(3.5±5.8 cm vs 1.6±0.5 cm,P=0.048).In the groups with tumor diameters>5 cm,both AR and NAR fail to obtain wide surgical margin(0.6±1.0 cm vs 0.7±0.4 cm,P=0.491).CONCLUSION For patients with a tumor diameter of 2-5 cm,AR can achieve the removal of peritumoral MVI by obtaining a wide incision margin,reduce postoperative recurrence,and improve prognosis.

Phase equilibria in Ti-rich portion and thermodynamic re-optimization of Co-Ti system

The experimental and thermodynamic studies of the Co-Ti system are an important part of the project to build a thermodynamic database for multicomponent Co-Ti-based alloys.Several key alloys were prepared and then examined for microstructural,compositional and thermal analyses to determine the Ti-rich phase equilibria.According to the available experimental information,the Co-Ti system was thermodynamically re-optimized on the basis of CALPHAD method.Four disordered solutions,liquid,fcc-A1(α-Co),bcc-A2(β-Ti)and hcp-A3(ε-Co andα-Ti)were modeled as substitutional ones.CoTi_(2)with limited solubility was treated as a stoichiometric compound,whileγ-Co_(2)Ti andβ-Co_(2)Ti with certain solubility were described in the form of(Co,Ti)2(Co,Ti)1 using a two-sublattice model.A single Gibbs energy function was employed to model two order–disorder transformations from fcc-A1 to fcc-L12(Co3Ti)and from bcc-A2 to bcc-B2(CoTi).A group of self-consistent thermodynamic parameters of the Co-Ti system were obtained.With these thermodynamic parameters,the experimental data can be described more reasonably and satisfactorily.