"Three-Component" Digital Prospecting Method: A New Approach for Mineral Resources Quantitative Prediction and Assessment

Three-component' method consists of three close-connected aspects: geological anomaly, diversity of mineralization and mineral deposit spectrum. All these three concepts are not new separately, but it is a new approach to combine these three aspects in one single concept for quantitative mineral resources prediction and assessment and it is also the first time to conduct a more detailed study in each aspect. Investigation and clarification of geological anomalies, diversity of mineralization and spectrum of mineral deposits are realized by digitization and quantification of ore forming controlling factors, ore-existing symbols or marks, characteristics of mineralization and regulation of ore-genesis and laws of distribution. These procedures lead to construction of a 'digital model' for mineral resources prediction and assessment.

Mfn2在糖尿病心肌病中的作用及机制研究进展

糖尿病是人类健康的主要威胁之一[1]。据估计,2021年全球20~79岁人群中的患病率为10.5%(5.37亿人),至2045年将升至12.2%(7.83亿人)[2]。糖尿病心肌病(diabetic cardiomyopathy,DCM)作为糖尿病患者的心血管并发症,是指没有高血压、冠状动脉粥样硬化性心脏病(冠心病)、严重瓣膜病和其他心血管危险因素情况下出现的心肌功能障碍[3,4],是引起糖尿病患者高死亡率的原因[5]。糖尿病心肌病的病理生理机制复杂,线粒体功能失调被认为是糖尿病并发症发生发展的主要病理机制[6]。线粒体作为一个高度动态的细胞器,其融合与分裂的平衡共同维持线粒体的正常功能。线粒体融合蛋白2(mitofusin 2,Mfn2)作为一种定位在线粒体外膜的融合蛋白,其过度表达引起的线粒体融合能更好地维持心肌细胞线粒体的功能,是纠正心肌细胞线粒体过度分裂更安全的策略[7]。本文将围绕Mfn2在糖尿病心肌病中作用的最新进展进行综述,以期加强对糖尿病心肌病的认识,为临床早期防治提供参考。