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幼儿园教师家长关系质量TCS模型建构 被引量:4
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作者 张晋 刘云艳 +1 位作者 杨晨晨 刘天 《学前教育研究》 CSSCI 北大核心 2021年第8期48-60,共13页
教师家长关系质量是教师与家长基于交往经历对当前双方关系水平是否符合自身价值需求的综合感知与评定,对儿童发展有深刻影响.本研究以22名幼儿家长、教师与管理者为深度访谈对象,依据扎根理论对访谈资料进行编码,结果发现信任(T)、承诺... 教师家长关系质量是教师与家长基于交往经历对当前双方关系水平是否符合自身价值需求的综合感知与评定,对儿童发展有深刻影响.本研究以22名幼儿家长、教师与管理者为深度访谈对象,依据扎根理论对访谈资料进行编码,结果发现信任(T)、承诺(C)与满意度(S)是幼儿园教师家长关系质量的关键维度.信任维度包括认知信任、情感信任与认同信任.承诺维度包括工具性承诺、情感性承诺与价值性承诺.满意度维度包括过程满意与结果满意.此关系质量模型符合当前突出人本取向的质量观,儿童、教师与家长的共同发展是教师家长关系应追求的主要价值."好的教师家长关系"应该是教师与家长彼此信任、相互做出承诺并都具有较高的满意度的关系.遵循此TCS模型,教师应不断提升关系增值能力,促使教师家长关系由形式关系转向质量关系,由单边关系转向双边关系,最终形成家园共育实践共同体. 展开更多
关键词 教师家长关系 关系质量 扎根理论
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Correction To:Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARSCoV-2 variants 被引量:2
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作者 Qian Wang chenchen yang +19 位作者 Li Yin Jing Sun Wei Wang Hengchun Li Zhengyuan Zhang Si Chen Bo Liu Zijian Liu Linjing Shi Xiaolin Liu Suhua Guan Chunhua Wang Linbing Qu Ying Feng Xuefeng Niu Liqiang Feng Jincun Zhao Pingchao Li Ling Chen Nanshan Zhong 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2023年第6期3184-3184,共1页
Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-023-01423-6,published online 17 April 2023 After online publication of the article^(1),the authors noticed two inadvertent mistakes... Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-023-01423-6,published online 17 April 2023 After online publication of the article^(1),the authors noticed two inadvertent mistakes occurred in References that needs to be corrected.The correct text is provided as follows. 展开更多
关键词 IMMUNITY MISTAKE noticed
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Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants 被引量:1
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作者 Qian Wang chenchen yang +19 位作者 Li Yin Jing Sun Wei Wang Hengchun Li Zhengyuan Zhang Si Chen Bo Liu Zijian Liu Linjing Shi Xiaolin Liu Suhua Guan Chunhua Wang Linbing Qu Ying Feng Xuefeng Niu Liqiang Feng Jincun Zhao Pingchao Li Ling Chen Nanshan Zhong 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2023年第5期2345-2353,共9页
The highly contagious SARS-CoV-2 Omicron subvariants severely attenuated the effectiveness of currently licensed SARS-CoV-2 vaccines based on ancestral strains administered via intramuscular injection.In this study,we... The highly contagious SARS-CoV-2 Omicron subvariants severely attenuated the effectiveness of currently licensed SARS-CoV-2 vaccines based on ancestral strains administered via intramuscular injection.In this study,we generated a recombinant,replication-incompetent human adenovirus type 5,Ad5-S-Omicron,that expresses Omicron BA.1 spike.Intranasal,but not intramuscular vaccination,elicited spike-specific respiratory mucosal IgA and residential T cell immune responses,in addition to systemic neutralizing antibodies and T cell immune responses against most Omicron subvariants.We tested intranasal Ad5-S-Omicron as a heterologous booster in mice that previously received intramuscular injection of inactivated ancestral vaccine.In addition to inducing serum broadly neutralizing antibodies,there was a significant induction of respiratory mucosal IgA and neutralizing activities against Omicron subvariants BA.1,BA.2,BA.5,BA.2.75,BF.7 as well as pre-Omicron strains Wildtype,Beta,and Delta.Serum and mucosal neutralizing activities against recently emerged XBB,BQ.1,and BQ.1.1 could also be detected but were much lower.Nasal lavage fluids from intranasal vaccination contained multimeric IgA that can bind to at least 10 spike proteins,including Omicron subvariants and pre-Omicron strains,and possessed broadly neutralizing activities.Intranasal vaccination using Ad5-S-Omicron or instillation of intranasal vaccinee’s nasal lavage fluids in mouse nostrils protected mice against Omicron challenge.Taken together,intranasal Ad5-S-Omicron booster on the basis of ancestral vaccines can establish effective mucosal and systemic immunity against Omicron subvariants and multiple SARS-CoV-2 variants.This candidate vaccine warrants further development as a safe,effective,and user-friendly infection and transmission-blocking vaccine. 展开更多
关键词 NASAL IMMUNITY MUCOSAL
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