To the Editor:Angiosarcoma(AS)is a rare and highly malignant mesenchymal tumor that accounts for 2%of adult soft tissue sarcomas.The prognosis of AS is poor due to the high rate of metastasis and reoccurrence.Accordin...To the Editor:Angiosarcoma(AS)is a rare and highly malignant mesenchymal tumor that accounts for 2%of adult soft tissue sarcomas.The prognosis of AS is poor due to the high rate of metastasis and reoccurrence.According to a retrospective study by Lahat et al and Fayette et al,[1,2]31 of 121(19%)patients had metastases upon initial diagnosis,and 90(74%)had relapse and progression.The median survival of AS was 3.4 years,declining to 10 months in patients with metastasis.To attempt to improve AS treatment outcomes,a multimodality approach is advocated,including surgical resection combined with radiation,chemotherapy,immunotherapy,and/or anti-angiogenetic therapy.Herein,we present a man who previously underwent resection of a mesorectal-derived intermediate hemangioendothelioma(HAE)and developed pulmonary metastasis of AS within a year.The history is remarkable because of(1)the rare primary location:only 2 cases were mesenteric-related;(2)the uncharacteristic clinical course:the primary diagnosis of intermediate hemangioendothelioma later progressed to pulmonary metastatic AS;and(3)a successful series of multidisciplinary therapeutic procedures,especially selective arterial infusion(SAI)chemotherapy before metastases resection.展开更多
文摘To the Editor:Angiosarcoma(AS)is a rare and highly malignant mesenchymal tumor that accounts for 2%of adult soft tissue sarcomas.The prognosis of AS is poor due to the high rate of metastasis and reoccurrence.According to a retrospective study by Lahat et al and Fayette et al,[1,2]31 of 121(19%)patients had metastases upon initial diagnosis,and 90(74%)had relapse and progression.The median survival of AS was 3.4 years,declining to 10 months in patients with metastasis.To attempt to improve AS treatment outcomes,a multimodality approach is advocated,including surgical resection combined with radiation,chemotherapy,immunotherapy,and/or anti-angiogenetic therapy.Herein,we present a man who previously underwent resection of a mesorectal-derived intermediate hemangioendothelioma(HAE)and developed pulmonary metastasis of AS within a year.The history is remarkable because of(1)the rare primary location:only 2 cases were mesenteric-related;(2)the uncharacteristic clinical course:the primary diagnosis of intermediate hemangioendothelioma later progressed to pulmonary metastatic AS;and(3)a successful series of multidisciplinary therapeutic procedures,especially selective arterial infusion(SAI)chemotherapy before metastases resection.
