BACKGROUND Primary peritoneal cancer(PPC)patients with BRCA mutations have a good prognosis;however,for patients with BRCA mutations who are diagnosed with PPC after prophylactic salpingo-oophorectomy(PSO),the prognos...BACKGROUND Primary peritoneal cancer(PPC)patients with BRCA mutations have a good prognosis;however,for patients with BRCA mutations who are diagnosed with PPC after prophylactic salpingo-oophorectomy(PSO),the prognosis is poor,and survival information is scarce.CASE SUMMARY We treated a 56-year-old woman with PPC after bilateral mastectomy,hysterectomy,and bilateral salpingo-oophorectomy.This patient had primary drug resistance and died 12 mo after the diagnosis of PPC.The genetic test performed on this patient indicated the presence of a germline BRCA1 mutation.We searched the PubMed,Scopus,and Cochrane databases and extracted studies of patients with BRCA mutations who developed PPC after PSO.After a detailed literature search,we found 30 cases,7 of which had a history of breast cancer,14 of which had no history of breast cancer,and 9 of which had an unknown history.The average age of PSO patients was 48.86 years old(range,31-64 years).The average time interval between the diagnosis of PPC and preventive surgery was 61.03 mo(range,12-292 mo).The 2-year survival rate for this patient population was 78.26%(18/23),the 3-year survival rate was 50.00%(9/18),and the 5-year survival rate was 6.25%(1/16).CONCLUSION Patients with BRCA mutations who are diagnosed with PPC after preventative surgery have a poor prognosis.Prevention measures and treatments for these patients need more attention.展开更多
文摘BACKGROUND Primary peritoneal cancer(PPC)patients with BRCA mutations have a good prognosis;however,for patients with BRCA mutations who are diagnosed with PPC after prophylactic salpingo-oophorectomy(PSO),the prognosis is poor,and survival information is scarce.CASE SUMMARY We treated a 56-year-old woman with PPC after bilateral mastectomy,hysterectomy,and bilateral salpingo-oophorectomy.This patient had primary drug resistance and died 12 mo after the diagnosis of PPC.The genetic test performed on this patient indicated the presence of a germline BRCA1 mutation.We searched the PubMed,Scopus,and Cochrane databases and extracted studies of patients with BRCA mutations who developed PPC after PSO.After a detailed literature search,we found 30 cases,7 of which had a history of breast cancer,14 of which had no history of breast cancer,and 9 of which had an unknown history.The average age of PSO patients was 48.86 years old(range,31-64 years).The average time interval between the diagnosis of PPC and preventive surgery was 61.03 mo(range,12-292 mo).The 2-year survival rate for this patient population was 78.26%(18/23),the 3-year survival rate was 50.00%(9/18),and the 5-year survival rate was 6.25%(1/16).CONCLUSION Patients with BRCA mutations who are diagnosed with PPC after preventative surgery have a poor prognosis.Prevention measures and treatments for these patients need more attention.
