一、锺正明实验室简史锺正明出生在临床医学世家,但他从小就对精彩纷呈的生命科学领域充满好奇心,因此他决定投身于基础医学科学研究。他于1978年获台湾大学学医学士学位后,赴美国洛克菲勒大学攻读博士学位。读博期间,他师从博士生导师...一、锺正明实验室简史锺正明出生在临床医学世家,但他从小就对精彩纷呈的生命科学领域充满好奇心,因此他决定投身于基础医学科学研究。他于1978年获台湾大学学医学士学位后,赴美国洛克菲勒大学攻读博士学位。读博期间,他师从博士生导师杰拉德•埃德尔曼(Gerald M.Edelman)教授,而导师因研究免疫球蛋白结构而荣获诺贝尔生理学或医学奖(Physiology or Medicine)。展开更多
Hair growth and regeneration represents a remarkable example of stem cell function.Recent progress emphasizes the micro-and macro-environment that controls the regeneration process.There is a shift from a stem cell-ce...Hair growth and regeneration represents a remarkable example of stem cell function.Recent progress emphasizes the micro-and macro-environment that controls the regeneration process.There is a shift from a stem cell-centered view toward the various layers of regulatory mechanisms that control hair regeneration,which include local growth factors,immune and neuroendocrine signals,and dietary and environmental factors.This is better suited for clinical applica-tion in multiple forms of hair disorders:in male pattern hair loss,the stem cells are largely preserved,but androgen signaling diminishes hair growth;in alopecia areata,an immune attack is targeted toward the growing hair follicle without abrogating its regeneration capability.Genome-wide association studies further revealed the genetic bases of these disorders,although the precise pathological mechanisms of the identified loci remain largely unknown.By analyzing the dysregulation of hair regeneration under pathological conditions,we can better address the complex interactions among stem cells,the differentiated progeny,and mesenchymal components,and highlight the critical role of macroenvironment adjustment that is essential for hair growth and regeneration.The poly-genetic origin of these disorders makes the study of hair regeneration an interesting and challenging field.展开更多
文摘一、锺正明实验室简史锺正明出生在临床医学世家,但他从小就对精彩纷呈的生命科学领域充满好奇心,因此他决定投身于基础医学科学研究。他于1978年获台湾大学学医学士学位后,赴美国洛克菲勒大学攻读博士学位。读博期间,他师从博士生导师杰拉德•埃德尔曼(Gerald M.Edelman)教授,而导师因研究免疫球蛋白结构而荣获诺贝尔生理学或医学奖(Physiology or Medicine)。
基金ZY is supported by the National Natural Science Foundation of China(NSFC 31871468)the Shenzhen University Stable Support Program(20200808172413001).
文摘Hair growth and regeneration represents a remarkable example of stem cell function.Recent progress emphasizes the micro-and macro-environment that controls the regeneration process.There is a shift from a stem cell-centered view toward the various layers of regulatory mechanisms that control hair regeneration,which include local growth factors,immune and neuroendocrine signals,and dietary and environmental factors.This is better suited for clinical applica-tion in multiple forms of hair disorders:in male pattern hair loss,the stem cells are largely preserved,but androgen signaling diminishes hair growth;in alopecia areata,an immune attack is targeted toward the growing hair follicle without abrogating its regeneration capability.Genome-wide association studies further revealed the genetic bases of these disorders,although the precise pathological mechanisms of the identified loci remain largely unknown.By analyzing the dysregulation of hair regeneration under pathological conditions,we can better address the complex interactions among stem cells,the differentiated progeny,and mesenchymal components,and highlight the critical role of macroenvironment adjustment that is essential for hair growth and regeneration.The poly-genetic origin of these disorders makes the study of hair regeneration an interesting and challenging field.
