类风湿关节炎(rheumatoid arthritis,RA)是一种临床常见的以滑膜炎为主的自身免疫性疾病。炎性细胞因子和破骨细胞刺激滑膜组织增生、炎症反应、骨质破坏及关节功能障碍等,在RA的致病因素中占据关键位置。本文对中药单体及其提取物、中...类风湿关节炎(rheumatoid arthritis,RA)是一种临床常见的以滑膜炎为主的自身免疫性疾病。炎性细胞因子和破骨细胞刺激滑膜组织增生、炎症反应、骨质破坏及关节功能障碍等,在RA的致病因素中占据关键位置。本文对中药单体及其提取物、中药复方及制剂、中药配伍,以及中医治疗通过调控骨保护蛋白(osteoprotegerin,OPG)/NF-κB受体激活因子(receptor activator of NF-κB,RANK)/NF-κB配体激活因子(receptor activator of NF-κB ligand,RANKL)信号通路干预RA的相关研究进行综述。结果表明,中药中的有效分子机制不同,但是可以起到调控信号通路的作用,刺激成骨细胞活性,抑制炎性细胞因子分泌,减少破骨细胞分化,从而防治RA,为中医药多靶点、多途径治疗RA提供理论依据。展开更多
骨纤维结构不良(fibrous dysplasia of bone,FD)是一种非遗传性疾病,其特点是纤维和骨组织的肿瘤样增生,目前治疗主要以手术为主。本文报道了1例男性股骨近端大范围FD合并病理性骨折的病例,其FD侵袭范围涉及股骨头、股骨颈、股骨粗隆间...骨纤维结构不良(fibrous dysplasia of bone,FD)是一种非遗传性疾病,其特点是纤维和骨组织的肿瘤样增生,目前治疗主要以手术为主。本文报道了1例男性股骨近端大范围FD合并病理性骨折的病例,其FD侵袭范围涉及股骨头、股骨颈、股骨粗隆间及股骨小转子下部近端,经病灶刮除+同种异体腓骨条支撑植骨+打压植骨+锁定接骨板内固定术治疗后,患者下肢生理长度及颈干角恢复,在25个月的随访中,下肢功能活动恢复情况良好,未见患肢疼痛或FD复发。展开更多
The sulfide passivation film produced on the surface seriously prevents further reaction in the process of using monoclinic pyrrhotite(MPr)to treat heavy metal ions in wastewater.Ultrasonic technology was introduced t...The sulfide passivation film produced on the surface seriously prevents further reaction in the process of using monoclinic pyrrhotite(MPr)to treat heavy metal ions in wastewater.Ultrasonic technology was introduced to assist MPr to recover the copper ions.XPS result proves that CuS products exist on the surface of MPr.XRD and SEM results show that the CuS on the particles’surface is stripped under ultrasonic condition.The kinetics results indicate that the reaction under both conventional and ultrasonic conditions conform to the Avrami model.The reaction process changes from diffusion control to chemical reaction control under the ultrasonic condition as the solid layer is stripped off.The presence of ultrasonic significantly reduces the acidity and temperature required for the reaction and enhances the utilization efficiency of MPr;by controlling the amount of MPr,the removal rates of copper and arsenic in copper smelting dust leachate exceed 99%and 95%,respectively.展开更多
文摘类风湿关节炎(rheumatoid arthritis,RA)是一种临床常见的以滑膜炎为主的自身免疫性疾病。炎性细胞因子和破骨细胞刺激滑膜组织增生、炎症反应、骨质破坏及关节功能障碍等,在RA的致病因素中占据关键位置。本文对中药单体及其提取物、中药复方及制剂、中药配伍,以及中医治疗通过调控骨保护蛋白(osteoprotegerin,OPG)/NF-κB受体激活因子(receptor activator of NF-κB,RANK)/NF-κB配体激活因子(receptor activator of NF-κB ligand,RANKL)信号通路干预RA的相关研究进行综述。结果表明,中药中的有效分子机制不同,但是可以起到调控信号通路的作用,刺激成骨细胞活性,抑制炎性细胞因子分泌,减少破骨细胞分化,从而防治RA,为中医药多靶点、多途径治疗RA提供理论依据。
文摘骨纤维结构不良(fibrous dysplasia of bone,FD)是一种非遗传性疾病,其特点是纤维和骨组织的肿瘤样增生,目前治疗主要以手术为主。本文报道了1例男性股骨近端大范围FD合并病理性骨折的病例,其FD侵袭范围涉及股骨头、股骨颈、股骨粗隆间及股骨小转子下部近端,经病灶刮除+同种异体腓骨条支撑植骨+打压植骨+锁定接骨板内固定术治疗后,患者下肢生理长度及颈干角恢复,在25个月的随访中,下肢功能活动恢复情况良好,未见患肢疼痛或FD复发。
基金the National Key Scientific Research Project,China(Nos.2018YFC1901601,2018YFC1901602)the Fundamental Research Funds for the Central Universities of Central South University,China(No.2021zzts0307)+2 种基金the National Natural Science Foundation of China(No.51804340)the Innovation-driven Plan of Central South University,China(No.2018CX036)the Collaborative Innovation Center for Clean and Efficient Utilization of Strategic Metal Mineral Resources,China,and Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources,China(No.2018TP1002).
文摘The sulfide passivation film produced on the surface seriously prevents further reaction in the process of using monoclinic pyrrhotite(MPr)to treat heavy metal ions in wastewater.Ultrasonic technology was introduced to assist MPr to recover the copper ions.XPS result proves that CuS products exist on the surface of MPr.XRD and SEM results show that the CuS on the particles’surface is stripped under ultrasonic condition.The kinetics results indicate that the reaction under both conventional and ultrasonic conditions conform to the Avrami model.The reaction process changes from diffusion control to chemical reaction control under the ultrasonic condition as the solid layer is stripped off.The presence of ultrasonic significantly reduces the acidity and temperature required for the reaction and enhances the utilization efficiency of MPr;by controlling the amount of MPr,the removal rates of copper and arsenic in copper smelting dust leachate exceed 99%and 95%,respectively.
