To explore the role of Human papillomavirus (HPV) in mammary carcinogenesis, the expression of the HPV-16, iNOS , P53 and hTERT proteins in breast carcinomas and their relationships were investigated. 52 samples of br...To explore the role of Human papillomavirus (HPV) in mammary carcinogenesis, the expression of the HPV-16, iNOS , P53 and hTERT proteins in breast carcinomas and their relationships were investigated. 52 samples of breast cancer and 16 samples of benign breast tumors were assayed using the immunohistochemical SP method for detection of protein expression levels. The expression of HPV-16, iNOS, P53 and hTERT proteins in a mammary carcinoma was 44.2%, 57.7%, 63.5% and 59.6% respectively, which was significantly greater than the corresponding levels in the benign group. The expression of iNOS, P53 and hTERT was correlated with the presence of an HPV-16 infection in a mammary carcinom(aP<0.05). The connection between these events might also involve the iNOS, mutated type P53 and the hTERT protein.展开更多
Background and aim:Immune checkpoint inhibitors(ICIs)are widely used in the treatment of liver cancer.However,the interaction with other drugs may change the efficacy of ICIs.Few studies investigated the effects of an...Background and aim:Immune checkpoint inhibitors(ICIs)are widely used in the treatment of liver cancer.However,the interaction with other drugs may change the efficacy of ICIs.Few studies investigated the effects of antibiotics(ATBs)on the efficacy of immunotherapy and the survival of patients with primary liver cancer receiving immunotherapy.This study aimed to explore the impact of ATBs on the efficacy of immunotherapy in patients with primary liver cancer.Methods:In total,215 patients with primary liver cancer who received ICIs from June 2018 to October 2020 were included for retrospective analysis.The progression-free survival(PFS),disease control rate(DCR),and overall survival(OS)were compared between patients treated with and without ATBs within 30 days before and after immunotherapy.Results:No significant differences in PFS(P=0.376)and OS(P=0.121)were found between patients treated with and without ATBs.Univariate and multivariate analyses showed that using ATBs was not associated with PFS,DCR,and OS.Conclusion:The use of ATBs within 30 days before and after immunotherapy in patients with primary liver cancer had no adverse effects on PFS,DCR,and OS.展开更多
基金Conducting item from HeilongJiang Land-reclamating General(HNKXIVID-009)
文摘To explore the role of Human papillomavirus (HPV) in mammary carcinogenesis, the expression of the HPV-16, iNOS , P53 and hTERT proteins in breast carcinomas and their relationships were investigated. 52 samples of breast cancer and 16 samples of benign breast tumors were assayed using the immunohistochemical SP method for detection of protein expression levels. The expression of HPV-16, iNOS, P53 and hTERT proteins in a mammary carcinoma was 44.2%, 57.7%, 63.5% and 59.6% respectively, which was significantly greater than the corresponding levels in the benign group. The expression of iNOS, P53 and hTERT was correlated with the presence of an HPV-16 infection in a mammary carcinom(aP<0.05). The connection between these events might also involve the iNOS, mutated type P53 and the hTERT protein.
基金This work was supported by the National Nature Science Foundation of China(Grant No.8177300881972897)+2 种基金the Clinical Research Startup Program of Southern Medical University by Highlevel University Construction Funding of Guangdong Provincial Department of Education(LC2019ZD003)the China Postdoctoral Science Foundation(No.2021M701629)the Guangdong Province College Students'Innovative Entrepreneurial Training Program(Grant No.S202212121108)of China.
文摘Background and aim:Immune checkpoint inhibitors(ICIs)are widely used in the treatment of liver cancer.However,the interaction with other drugs may change the efficacy of ICIs.Few studies investigated the effects of antibiotics(ATBs)on the efficacy of immunotherapy and the survival of patients with primary liver cancer receiving immunotherapy.This study aimed to explore the impact of ATBs on the efficacy of immunotherapy in patients with primary liver cancer.Methods:In total,215 patients with primary liver cancer who received ICIs from June 2018 to October 2020 were included for retrospective analysis.The progression-free survival(PFS),disease control rate(DCR),and overall survival(OS)were compared between patients treated with and without ATBs within 30 days before and after immunotherapy.Results:No significant differences in PFS(P=0.376)and OS(P=0.121)were found between patients treated with and without ATBs.Univariate and multivariate analyses showed that using ATBs was not associated with PFS,DCR,and OS.Conclusion:The use of ATBs within 30 days before and after immunotherapy in patients with primary liver cancer had no adverse effects on PFS,DCR,and OS.
