DNA的化学修饰可以使DNA分子具有其他功能,如构建DNA编码化合物库(DNA-encoded chemical libraries,DECLs)、制备用于生物传感的DNA探针、提高DNA适配体的结合活性等.对DNA化学修饰反应效率已有的研究集中在对反应条件(溶剂、温度等)的...DNA的化学修饰可以使DNA分子具有其他功能,如构建DNA编码化合物库(DNA-encoded chemical libraries,DECLs)、制备用于生物传感的DNA探针、提高DNA适配体的结合活性等.对DNA化学修饰反应效率已有的研究集中在对反应条件(溶剂、温度等)的优化,为了确定影响修饰效率的重要因素,我们以DNA-NH_2的酰化反应为模型进行了系统研究.结果表明,影响DNA-NH_2酰化反应的主要因素是DNA和酰化试剂的分子量.相反,DNA的结构在反应中起着次要的作用.展开更多
Wireframe, polyhedral, supramolecular complexes made of DNA have uniform sizes, defined three-dimensional shapes, porous facets, hollow interiors, good biocompatibilities, and chemical functionalizability. They confer...Wireframe, polyhedral, supramolecular complexes made of DNA have uniform sizes, defined three-dimensional shapes, porous facets, hollow interiors, good biocompatibilities, and chemical functionalizability. They confer great potentials in bottom-up nanoengineering towards various applications. In this review, we summarize recent ad- vances in the rational design and programmed assembly of DNA wireframe polyhedra. Their assembly is based on three distinctively different strategies： individual strands-based assembly, tile-based assembly, and scaffolded DNA origami. Applications of these polyhedral structures in templated nanomaterial assembly and in-vivo cargo delivery are discussed. In the future, expanding the structural complexity and exploring their applications, especially in na- nomaterials science and biomedicines, should be a primary focus of this rapidly developing and evolving activity of structural DNA nanotechnology.展开更多
Using synthetic nanorobots to efficiently and safely execute therapeutic functions in human bodies is a long-standing dream.In the recent issue of Nature Biotechnology,a paper describes the latest development in such ...Using synthetic nanorobots to efficiently and safely execute therapeutic functions in human bodies is a long-standing dream.In the recent issue of Nature Biotechnology,a paper describes the latest development in such an attempt to implement an autonomous DNA robot in cancer therapy[1].Upon being injected into animals,the DNA nanorobots can find and destroy life-threatening tumors.展开更多
文摘DNA的化学修饰可以使DNA分子具有其他功能,如构建DNA编码化合物库(DNA-encoded chemical libraries,DECLs)、制备用于生物传感的DNA探针、提高DNA适配体的结合活性等.对DNA化学修饰反应效率已有的研究集中在对反应条件(溶剂、温度等)的优化,为了确定影响修饰效率的重要因素,我们以DNA-NH_2的酰化反应为模型进行了系统研究.结果表明,影响DNA-NH_2酰化反应的主要因素是DNA和酰化试剂的分子量.相反,DNA的结构在反应中起着次要的作用.
基金This work was supported by the National Natural Science Foundation of China （Nos. 21273214, 21521001 and 21605033）, the National Science Fund for Distinguished Young Scholars （No. 21425521）, the National Key Research and Development Program of China （No. 2016YFA0201300）, Hefei Center for Physi- cal Science and Technology （No. 2014FXCX010）, the Collaborative Innovation Center of Suzhou Nano Science and Technology, the Fundamental Research Funds for the Central Universities （No. JZ2016HGPA0734）, and start-up funding from Hefei University of Technology.
文摘Wireframe, polyhedral, supramolecular complexes made of DNA have uniform sizes, defined three-dimensional shapes, porous facets, hollow interiors, good biocompatibilities, and chemical functionalizability. They confer great potentials in bottom-up nanoengineering towards various applications. In this review, we summarize recent ad- vances in the rational design and programmed assembly of DNA wireframe polyhedra. Their assembly is based on three distinctively different strategies： individual strands-based assembly, tile-based assembly, and scaffolded DNA origami. Applications of these polyhedral structures in templated nanomaterial assembly and in-vivo cargo delivery are discussed. In the future, expanding the structural complexity and exploring their applications, especially in na- nomaterials science and biomedicines, should be a primary focus of this rapidly developing and evolving activity of structural DNA nanotechnology.
文摘Using synthetic nanorobots to efficiently and safely execute therapeutic functions in human bodies is a long-standing dream.In the recent issue of Nature Biotechnology,a paper describes the latest development in such an attempt to implement an autonomous DNA robot in cancer therapy[1].Upon being injected into animals,the DNA nanorobots can find and destroy life-threatening tumors.
