Alzheimer's disease(AD)is a progressive neurodegenerative disorder associated with cognitive impairment in older adults.The accumulation of insoluble forms of amyloid-β(Aβ)in plaques in extracellular spaces and ...Alzheimer's disease(AD)is a progressive neurodegenerative disorder associated with cognitive impairment in older adults.The accumulation of insoluble forms of amyloid-β(Aβ)in plaques in extracellular spaces and the aggregation of hyperphosphorylated microtubule-associated protein tau in neurofibrillary tangles in neurons are considered to be central pathological features of A D[1,2].展开更多
文摘Alzheimer's disease(AD)is a progressive neurodegenerative disorder associated with cognitive impairment in older adults.The accumulation of insoluble forms of amyloid-β(Aβ)in plaques in extracellular spaces and the aggregation of hyperphosphorylated microtubule-associated protein tau in neurofibrillary tangles in neurons are considered to be central pathological features of A D[1,2].
