SARS-CoV-2 has been demonstrated to be highly susceptible to neuron-and glial-like cells,1 but there is no consensus regarding how the virus affects neurons following neuroinvasion.It is therefore unknown if and how S...SARS-CoV-2 has been demonstrated to be highly susceptible to neuron-and glial-like cells,1 but there is no consensus regarding how the virus affects neurons following neuroinvasion.It is therefore unknown if and how SARS-CoV-2 maintains the homeostasis of neuronal cells.Herein,we revealed that the receptor-binding domain(RBD)of the SARS-CoV-2 spike protein acted as an extracellular remodeling component to undermine epigenetic regulation,perturbnascentRNA(nsRNA)transcription,promote mitochondrial biogenesis,and increase cellular viability in SH-SY5Y cells.展开更多
基金supported by grants from The National Natural Science Foundation of China(No.81971132,82271306)the Sichuan Science and Technology Program(China)(No.2021ZYD0106,2021ZYD0091,22ZDYF3783,2022YFS0615,2023YFH0069,2023NSFSC0028,2023NSFSC1559)+1 种基金Project of Luzhou Science and Technology Bureau(No.2021LZXNYDP01,2021LZXNYD-Z05)Luzhou Government-Southwest Medical University Strategic Cooperation Project and Southwest Medical University Project(Sichuan,China)(No.2021ZKQN058,2020ZRQNB072,2021ZKZD013,2021ZKQN041).
文摘SARS-CoV-2 has been demonstrated to be highly susceptible to neuron-and glial-like cells,1 but there is no consensus regarding how the virus affects neurons following neuroinvasion.It is therefore unknown if and how SARS-CoV-2 maintains the homeostasis of neuronal cells.Herein,we revealed that the receptor-binding domain(RBD)of the SARS-CoV-2 spike protein acted as an extracellular remodeling component to undermine epigenetic regulation,perturbnascentRNA(nsRNA)transcription,promote mitochondrial biogenesis,and increase cellular viability in SH-SY5Y cells.
