To the Editor:Parkinson’s disease(PD)is one of the most common neurodegenerative disorders and the most common movement disorder worldwide.PD pathogenesis has been demonstrated to be associated with neuroinflammation...To the Editor:Parkinson’s disease(PD)is one of the most common neurodegenerative disorders and the most common movement disorder worldwide.PD pathogenesis has been demonstrated to be associated with neuroinflammation and intestinal inflammation.Increased C-reactive protein(CRP)levels were related to freezing of gait and rapid PD progression,particularly in elderly patients.Recent research indicates that immune cells in peripheral blood might also contribute to PD pathogenesis,providing further insight into the relationship between inflammation and PD.展开更多
To the Editor:Alterations of circadian rhythms seem to be the casual contribution to sleep disturbances,depression,and other non-motor symptoms in Parkinson's disease(PD).[1,2]By restoring the circadian rhythm,bri...To the Editor:Alterations of circadian rhythms seem to be the casual contribution to sleep disturbances,depression,and other non-motor symptoms in Parkinson's disease(PD).[1,2]By restoring the circadian rhythm,bright light therapy(BLT)might be a potentially new treatment option for PD.However,no studies have conclusively demonstrated the effects of BLT on the non-motor symptoms in PD.展开更多
To the Editor:Parkinson’s disease(PD)is the second most common neurodegenerative disorder,and sleep disturbance is a major disabling non-motor symptom.[1]Excessive daytime sleepiness(EDS)is defined as inappropriate a...To the Editor:Parkinson’s disease(PD)is the second most common neurodegenerative disorder,and sleep disturbance is a major disabling non-motor symptom.[1]Excessive daytime sleepiness(EDS)is defined as inappropriate and undesirable sleepiness during waking hours,which may occur during activities such as talking or driving.In PD patients,EDS increased the risk of accidents and resulted in a poor quality of life.[2]展开更多
基金social development projects in Jiangsu Province(No.BE2018658)Jiangsu Provincial Medical Key Discipline Project(No.ZDXKB2016022)+2 种基金Suzhou Science and Technology Development Program(No.SYS2020131)Discipline Construction Program of The Second Affiliated Hospital of Soochow University(No.XKTJ-XK202001)The Second Hospital of Soochow University Young Staff Pre-Research Fund Project(No.SDFEYQN1807)
文摘To the Editor:Parkinson’s disease(PD)is one of the most common neurodegenerative disorders and the most common movement disorder worldwide.PD pathogenesis has been demonstrated to be associated with neuroinflammation and intestinal inflammation.Increased C-reactive protein(CRP)levels were related to freezing of gait and rapid PD progression,particularly in elderly patients.Recent research indicates that immune cells in peripheral blood might also contribute to PD pathogenesis,providing further insight into the relationship between inflammation and PD.
基金This work was supported by grants from the Jiangsu Provincial Key R&D Program(No.BE2018658)the Jiangsu Provincial Medical Key Discipline Project(No.ZDXKB2016022)+2 种基金Discipline Construction Program of the Second Affiliated Hospital Soochow University(No.XKTJ-XK202001)the National Natural Science Foundation of China(No.81801253)the Natural Science Foundation of Jiangsu Province(BK 20180214).
文摘To the Editor:Alterations of circadian rhythms seem to be the casual contribution to sleep disturbances,depression,and other non-motor symptoms in Parkinson's disease(PD).[1,2]By restoring the circadian rhythm,bright light therapy(BLT)might be a potentially new treatment option for PD.However,no studies have conclusively demonstrated the effects of BLT on the non-motor symptoms in PD.
基金supported by grants from Jiangsu Provincial Key R&D Program(BE2018658)Suzhou Science and Technology Development Plan(Minsheng Science and Technology)(SKJY2021089)+1 种基金Discipline Construction Program of the Second Affiliated Hospital of Soochow University(XKTJ-XK202001)Gusu Health Talents Plan(GSWS2020035,GSWS2019041).
文摘To the Editor:Parkinson’s disease(PD)is the second most common neurodegenerative disorder,and sleep disturbance is a major disabling non-motor symptom.[1]Excessive daytime sleepiness(EDS)is defined as inappropriate and undesirable sleepiness during waking hours,which may occur during activities such as talking or driving.In PD patients,EDS increased the risk of accidents and resulted in a poor quality of life.[2]
