A carbene-catalyzed ester activation reaction for the synthesis of multi-substituted benzenes is developed. Tetra-substituted benzene com- pounds are efficiently synthesized through this methodology. Compared with ald...A carbene-catalyzed ester activation reaction for the synthesis of multi-substituted benzenes is developed. Tetra-substituted benzene com- pounds are efficiently synthesized through this methodology. Compared with aldehyde substrates used in previous reports, the ester substrates used here are much more readily available and inexpensive. In addition, the TEMPO oxidant used here is more inexpensive than the quinones commonly used in related carbene-catalyzed reactions.展开更多
基金We acknowledge financial support by the National Natural Science Foundation of China （No. 21472028）, the National Key Technologies R＆D Program （No. 2014BAD23B01）, the ＂Thousand Talent Plan＂, the 10 Talent Plan （Shicengci） of Guizhou Province, Guizhou Province Returned Oversea Student Science and Technol- ogy Activity Program, and Guizhou University （China）.
文摘A carbene-catalyzed ester activation reaction for the synthesis of multi-substituted benzenes is developed. Tetra-substituted benzene com- pounds are efficiently synthesized through this methodology. Compared with aldehyde substrates used in previous reports, the ester substrates used here are much more readily available and inexpensive. In addition, the TEMPO oxidant used here is more inexpensive than the quinones commonly used in related carbene-catalyzed reactions.
