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乌司奴单抗改善中、重度斑块状银屑病患者健康相关生活质量和临床疗效观察 被引量:4
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作者 朱学骏 郑敏 +4 位作者 Michael Song chenglong han Daphne Chan Y.K.Shen 王宝玺 《临床皮肤科杂志》 CAS CSCD 北大核心 2014年第9期521-526,共6页
目的:评估乌司奴单抗对中国3期、双盲、安慰剂对照临床(LOTUS)研究患者健康相关生活质量(HRQoL)的影响。方法:共322例患者,在第0周和第4周随机接受乌司奴单抗45mg(n=160)或安慰剂(n=162);第12周和第16周安慰剂组交叉使用乌司奴单抗,而... 目的:评估乌司奴单抗对中国3期、双盲、安慰剂对照临床(LOTUS)研究患者健康相关生活质量(HRQoL)的影响。方法:共322例患者,在第0周和第4周随机接受乌司奴单抗45mg(n=160)或安慰剂(n=162);第12周和第16周安慰剂组交叉使用乌司奴单抗,而乌司奴单抗组则在第16周继续使用乌司奴单抗。第12周HRQoL终点包括皮肤病生活质量指数(DLQI)评分较基线的变化、单个DLQI域的变化、DLQI评分为0分或1分的患者比例以及获得有临床意义DLQI改善(评分降低≥5分)的患者比例。结果:乌司奴单抗治疗患者12周时DLQI评分较基线的改善(-9.3分)显著优于安慰剂组(-1.9分)(P<0.001)。同样,乌司奴单抗治疗后DLQI≤1分的患者比例显著高于安慰剂组(42.6%vs 10.7%,P<0.001),乌司奴单抗组和安慰剂组治疗后分别有71.5%和29.6%的患者DLQI降低≥5分(P均<0.001)。乌司奴单抗治疗患者12周时单个DLQI域与安慰剂相比显著改善(P<0.001)。乌司奴单抗组DLQI的改善在治疗28周内持续存在。交叉接受乌司奴单抗的安慰剂组患者,与最初随机接受乌司奴单抗治疗的患者相比,HRQoL改善程度类似。结论:乌司奴单抗显著改善了中国中至重度斑块状银屑病患者的HRQoL。 展开更多
关键词 银屑病 乌司奴单抗 健康相关生活质量
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Finite Difference Simulation of Implosive Collapsing for Aluminum Spherical Shell
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作者 Weicheng Bi Banghai Jiang chenglong han 《Journal of Applied Mathematics and Physics》 2018年第8期1606-1613,共8页
Implosive collapsing for spherical metal shells is a kind of dynamic compressing method, in which high pressure and high compression degree of materials can be attained. In present work, the dynamic process of implosi... Implosive collapsing for spherical metal shells is a kind of dynamic compressing method, in which high pressure and high compression degree of materials can be attained. In present work, the dynamic process of implosive collapsing for spherical metal shells was regard as spherical symmetry ideally, so one-dimensional spherical symmetric fluid dynamics conservation equations were established, and the finite difference schemes for solving these equations were given. An aluminum spherical shell was assumed, whose inner radius is 4cm and thickness is 2 cm. In numerical simulation, initial centripetal velocities (800, 1000 and 1200 m/s) were used to make aluminum spherical shell collapse. The simulation results show that during the process of implosive collapsing, the material exhibits a compression-expansion-compression pulsation process, and the internal pressure changes and distribution are consistent with the theoretical expectations. The simulation results can be used as a reference for relevant analysis. 展开更多
关键词 Implosive COLLAPSE SPHERICAL SHELL Finite DIFFERENCE Numerical SIMULATION
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