Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism

Vascular etiology is the second most prevalent cause of cognitive impairment globally.Endothelin-1,which is produced and secreted by endothelial cells and astrocytes,is implicated in the pathogenesis of stroke.However,the way in which changes in astrocytic endothelin-1 lead to poststroke cognitive deficits following transient middle cerebral artery occlusion is not well understood.Here,using mice in which astrocytic endothelin-1 was overexpressed,we found that the selective overexpression of endothelin-1 by astrocytic cells led to ischemic stroke-related dementia(1 hour of ischemia;7 days,28 days,or 3 months of reperfusion).We also revealed that astrocytic endothelin-1 overexpression contributed to the role of neural stem cell proliferation but impaired neurogenesis in the dentate gyrus of the hippocampus after middle cerebral artery occlusion.Comprehensive proteome profiles and western blot analysis confirmed that levels of glial fibrillary acidic protein and peroxiredoxin 6,which were differentially expressed in the brain,were significantly increased in mice with astrocytic endothelin-1 overexpression in comparison with wild-type mice 28 days after ischemic stroke.Moreover,the levels of the enriched differentially expressed proteins were closely related to lipid metabolism,as indicated by Kyoto Encyclopedia of Genes and Genomes pathway analysis.Liquid chromatography-mass spectrometry nontargeted metabolite profiling of brain tissues showed that astrocytic endothelin-1 overexpression altered lipid metabolism products such as glycerol phosphatidylcholine,sphingomyelin,and phosphatidic acid.Overall,this study demonstrates that astrocytic endothelin-1 overexpression can impair hippocampal neurogenesis and that it is correlated with lipid metabolism in poststroke cognitive dysfunction.

基于熵权法的电子工业行业绩效指标构建与评价研究

本文基于熵权法和K-Means聚类算法,构建并评价了2012—2021年沪深两市A股电子工业上市公司的绩效指标体系。研究选取半导体、元件、光学光电子、消费电子四大细分行业,从盈利能力、资产质量、债务风险、经营状况四大维度出发,揭示了不同细分行业内企业绩效的差异,并探讨了企业发展的不足及其可能的影响因素。研究发现,半导体行业盈利能力最强,元件行业资产质量最优,消费电子行业经营增长速度最快。最后,文章提出了针对电子工业行业发展的政策建议,强调创新驱动、金融支持与产业升级的重要性。

Defective/Doped Graphene-Based Materials as Cathodes for Metal-Air Batteries

Graphene,as a proof-of-concept two-dimensional material,has proven to have excellent physical and chemical properties.Its derivatives,such as defective or doped graphene,are also applied as catalytic materials for metal-air batteries(MABs).MABs have been recognized as possible candidates for new-generation energy storage systems due to their ultra-high theoretical energy density.So far,graphene and its derivatives with optimized structures have been widely explored to improve the electrochemical performance in MABs.Generally speaking,perfect graphene crystalline is inert for many catalytic processes,while defects and heteroatoms can endow graphene with high activity for many electrocatalytic reactions.Under this circumstance,recent progress is summarized for defective/doped graphene as air cathodes in aqueous or organic MABs,which are actually different electrochemical systems with distinct requirements for air cathodes.Also,the relationship is clarified between graphene defects/doping and electrocatalytic mechanisms that can be the guidance for catalyst design.Future directions are also prospected for the development of graphene-based MAB cathodes.

The Preliminary Design of IPv6 Home Gateway and Terminal

This paper briefly analyzes the advantages of IPv6 used at Intelligent home and describes an IPv6 home network frame. It also studies IPv6 transition technical problems facing home gateways and gives the summaries to the main protocol of each node of home network and their mutual relations. The key nodes of the home network based on IPv6, including the hardware design and software design of the home gateway and home network controller, are systematically de-signed in the paper. Finally, it illustrates the actual test environment and test in detail. The paper gives a view of the fact that the intelligent home appliances are becoming the current trend with the accelerating the transition of IPv4 to IPv6 and home network-wide implementation of IPv6 is about to become a reality, holding that the network controllers and home gateway based on ARM processor can support IPv6 and carry on the implementation of remote control and local control based on Web Browser.

The Analysis of the Structure and Security of Home Control Subnet

A lot of technologies can be used in home control subnet, but the hardware and software resources available for the home control subnet are limited. There are security problems easily seen. The paper gives the system-atic analysis of the structure and function of home control subnet based on the general model of home net-work. The paper has also analyzed two types of major equipment, namely sub-gateways and terminal equip-ment. The major networking technology used in home control subnet is summarized and concluded. In com-bination with relationship among home control subnet, home network, as well as the outside main network, the paper has systematically studied various safety problems related to home control gateways and the possi-ble solutions to those problems have been made.

Investigation of adsorption/desorption behavior of Cr(Ⅵ) at the presence of inorganic and organic substance in membrane capacitive deionization(MCDI)

The adsorption and desorption behavior of Cr(Ⅵ) in membrane capacitive deionization(MCDI) was investigated systematically in the presence of bovine serum albumin(BSA) and KCl with different concentrations, respectively. Results revealed that Cr(Ⅵ) absorption was enhanced and the adsorption amount for Cr(Ⅵ) increased from 155.7 to 190.8 mg/g when KCl concentration increased from 100 to 200 mg/L in the adsorption process, which was attributed to the stronger driving force. However, the adsorption amount sharply decreased to 90.2 mg/g when KCl concentration reached up to 1000 mg/L suggesting the negative effect for Cr(Ⅵ) removal that high KCl concentration had. As for the effect of BSA on ion adsorption, the amount for Cr(Ⅵ) significantly declined to 78.3 mg/g and p H was found to be an important factor contributing to this significant reduction. Then, the desorption performance was also conducted and it was obtained that the presence of KCl had negligible effect on Cr(Ⅵ) desorption, while promoted by the addition of BSA. The incomplete desorption was obtained and the residual chromium ions onto the electrode after desorption was detected via energy-dispersive X-ray spectroscopy(EDS). Based on above analysis, the enhanced removal mechanism for Cr(Ⅵ) in MCDI was found to be consisted of ion adsorption onto electrode surface, the redox reaction of Cr(Ⅵ) into Cr(III)and precipitation, which was demonstrated by X-ray photoelectron spectroscopy(XPS) and scanning electron microscope(SEM).

Camera localization for augmented reality and indoor positioning:a vision-based 3D feature database approach

The recent fast development in computer vision and mobile sensor technology such as mobile LiDAR and RGB-D cameras is pushing the boundary of the technology to suit the need of real-life applications in the fields of Augmented Reality(AR),robotics,indoor GIS and self-driving.Camera localization is often a key and enabling technology among these applications.In this paper,we developed a novel camera localization workflow based on a highly accurate 3D prior map optimized by our RGBD SLAM method in conjunction with a deep learning routine trained using consecutive video frames labeled with high precision camera pose.Furthermore,an AR registration method tightly coupled with a game engine is proposed,which incorporates the proposed localization algorithm and aligns the real Kinetic camera with a virtual camera of the game engine to facilitate AR application development in an integrated manner.The experimental results show that the localization accuracy can achieve an average error of 35 cm based on a fine-tuned prior 3D feature database at 3 cm accuracy compared against the ground-truth 3D LiDAR map.The influence of the localization accuracy on the visual effect of AR overlay is also demonstrated and the alignment of the real and virtual camera streamlines the implementation of AR fire emergency response demo in a Virtual Geographic Environment.

One-pot enantioselective construction of 3,4-dihydro-2H-1,4-oxazines over Ru/Au relay catalysis and its mechanistic serendipity

The preparation of enantiomerically pure 1,4-oxazines remains a continuous challenge in synthetic chemistry because of their potential application in the total synthesis of morpholines.Herein,a one-pot asymmetric transfer hydrogenation/cyclization enantio-relay process catalyzed by Ru and Au bimetallic catalysts was developed.This enantio-relay process firstly allows the asymmetric transfer hydrogenation of alkynones to form chiral alkynols in the presence of(S,S)-mesityleneRuClTsDPEN(TsDPEN=N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine)and then the chiral alkynols could be converted into 3,4-dihydro-2H-1,4-oxazines in moderate to good yields with excellent enantioselectivity retention accompanied by AuCl(PPh_(3))/AgNTf_(2) and HCOOH.A series of sulfonamide-tethered alkynones were well tolerated in this process.Mechanistic studies indicated that the alkynols formed in the first step were initially transformed into a methylenemorpholine intermediate when AuCl(PPh_(3))/AgNTf_(2) and HCOOH were added,which can be further isomerized into chiral 3,4-dihydro-2H-1,4-oxazines with the addition of a second HCOOH.This protocol offers not only a practical method to access 3,4-dihydro-2H-1,4-oxazines from alkynones in an enantioselective version,but also enriches the arsenal of gold chemistry from a mechanistic point of view.