DNA-based supramolecular hydrogels are important and promising biomaterials for various applications due to their inherent biocompatibility and tunable physicochemical properties.The three-dimensional supramolecular m...DNA-based supramolecular hydrogels are important and promising biomaterials for various applications due to their inherent biocompatibility and tunable physicochemical properties.The three-dimensional supramolecular matrix of DNA formed by non-covalently dynamic cross-linking provides exceptional adaptability,self-healing,injectable and responsive properties for hydrogels.In addition,DNA hydrogels are also ideal bio-scaffold materials owing to their tissue-like mechanics and intrinsic biological functions.Technically,DNA can assemble into supramolecular networks by pure complementary base pairing;it can also be combined with other building blocks to construct hybrid hydrogels.This review focuses on the development and construction strategies of DNA hydrogels.Assembly and synthesis methods,diverse responsiveness and biomedical applications are summarized.Finally,the challenges and prospects of DNA-based supramolecular hydrogels are discussed.展开更多
Spherical bimetallic cobalt-lanthanum oxides were loaded on the surface of electrospun carbon fiber by simple hydrothermal method and an electrochemical sensor was successfully constructed for simultaneous detection o...Spherical bimetallic cobalt-lanthanum oxides were loaded on the surface of electrospun carbon fiber by simple hydrothermal method and an electrochemical sensor was successfully constructed for simultaneous detection of amlodipine and acetami-nophen.Carbon fiber,as an electron transport channel,is cooperated with bimetallic oxides to provide uniformly dispersed active sites and enhance the conductivity of the composite.The linear relationships between amlodipine and acetaminophen are 10-1000µM and 5-1600µM,and the detection limits are 0.86µM and 0.25µM,respectively.Furthermore,experiments reveal that the sensor exhibits good stability,and satisfactory recovery rate has been obtained in the detection of two practi-cal drugs.展开更多
基金support from the Shanghai Municipal Science and Technology Major Project(No.2021SHZDZX0100)the National Natural Science Foundation of China(Nos.22109117,22272119)+2 种基金the Science and Technology Committee of Shanghai Municipality(No.2022-4-ZD-03)Shanghai Pilot Program for Basic Research,China Postdoctoral Science Foundation(No.2021M692418)the Fundamental Research Funds for the Central Universities.
文摘DNA-based supramolecular hydrogels are important and promising biomaterials for various applications due to their inherent biocompatibility and tunable physicochemical properties.The three-dimensional supramolecular matrix of DNA formed by non-covalently dynamic cross-linking provides exceptional adaptability,self-healing,injectable and responsive properties for hydrogels.In addition,DNA hydrogels are also ideal bio-scaffold materials owing to their tissue-like mechanics and intrinsic biological functions.Technically,DNA can assemble into supramolecular networks by pure complementary base pairing;it can also be combined with other building blocks to construct hybrid hydrogels.This review focuses on the development and construction strategies of DNA hydrogels.Assembly and synthesis methods,diverse responsiveness and biomedical applications are summarized.Finally,the challenges and prospects of DNA-based supramolecular hydrogels are discussed.
基金The authors thank the National Natural Science Foundation of China(No.21671132).
文摘Spherical bimetallic cobalt-lanthanum oxides were loaded on the surface of electrospun carbon fiber by simple hydrothermal method and an electrochemical sensor was successfully constructed for simultaneous detection of amlodipine and acetami-nophen.Carbon fiber,as an electron transport channel,is cooperated with bimetallic oxides to provide uniformly dispersed active sites and enhance the conductivity of the composite.The linear relationships between amlodipine and acetaminophen are 10-1000µM and 5-1600µM,and the detection limits are 0.86µM and 0.25µM,respectively.Furthermore,experiments reveal that the sensor exhibits good stability,and satisfactory recovery rate has been obtained in the detection of two practi-cal drugs.
