Oligodendrocyte precursor cells(OPCs)are a heterogeneous multipotent population in the central nervous system(CNS)that appear during embryogenesis and persist as resident cells in the adult brain parenchyma.OPCs could...Oligodendrocyte precursor cells(OPCs)are a heterogeneous multipotent population in the central nervous system(CNS)that appear during embryogenesis and persist as resident cells in the adult brain parenchyma.OPCs could generate oligodendrocytes to participate in myelination.Recent advances have renewed our knowledge of OPC biology by discovering novel markers of oligodendroglial cells,the myelin-independent roles of OPCs,and the regulatory mechanism of OPC development.In this review,we will explore the updated knowledge on OPC identity,their multifaceted roles in the CNS in health and diseases,as well as the regulatory mechanisms that are involved in their developmental stages,which hopefully would contribute to a further understanding of OPCs and attract attention in the field of OPC biology.展开更多
基金supported by grants from the National Natural Science Foundation of China (32271034,32070964,81971309,32170980,and 32300791)National Key Research and Development Program of China (2021ZD0201703)+4 种基金Chongqing Natural Science Fund for Distinguished Young Scholars (CSTB2023NSCQ-JQX0030)Guangdong Basic and Applied Basic Research Foundation (2022B1515020012,2021A1515110268,2023A1515010651)Shenzhen Medical Research Fund (A2303014)Shenzhen Fundamental Research Program (JCYJ20210324123212035,RCYX20200714114644167,ZDSYS20220606100801003,RCBS20210706092411028,and JCYJ20210324121214039)Shenzhen Key Laboratory of Chinese Medicine Active Substance Screening and Translational Research (ZDSYS20220606100801003).
文摘Oligodendrocyte precursor cells(OPCs)are a heterogeneous multipotent population in the central nervous system(CNS)that appear during embryogenesis and persist as resident cells in the adult brain parenchyma.OPCs could generate oligodendrocytes to participate in myelination.Recent advances have renewed our knowledge of OPC biology by discovering novel markers of oligodendroglial cells,the myelin-independent roles of OPCs,and the regulatory mechanism of OPC development.In this review,we will explore the updated knowledge on OPC identity,their multifaceted roles in the CNS in health and diseases,as well as the regulatory mechanisms that are involved in their developmental stages,which hopefully would contribute to a further understanding of OPCs and attract attention in the field of OPC biology.
