Interactions between diet and the intestinal microbiome play an important role in human health and disease development.It is well known that such interactions,whether direct or indirect,trigger a series of metabolic r...Interactions between diet and the intestinal microbiome play an important role in human health and disease development.It is well known that such interactions,whether direct or indirect,trigger a series of metabolic reactions in the body.Evidence suggests that intestinal stem cells(ISCs),which are phenotypic precursors of various intestinal epithelial cells,play a significant role in the regulation of intestinal barrier function and homeostasis.The advent and evolution of intestinal organoid culture techniques have presented a key opportunity to study the association between the intestinal microenvironment and ISCs.As a result,the effects exerted by dietary factors,intestinal microbiomes,and their metabolites on the metabolic regulation of ISCs and the potential mechanisms underlying such effects are being gradually revealed.This review summarises the effects of different dietary patterns on the behaviour and functioning of ISCs and focuses on the crosstalk between intestinal microbiota,related metabolites,and ISCs,with the aim of fully understanding the relationship between these three factors and providing further insights into the complex mechanisms associated with ISCs in the human body.Gaining an understanding of these mechanisms may lead to the development of novel dietary interventions or drugs conducive to intestinal health.展开更多
Coronavirus disease 2019(COVID-19)has spread rapidly since its outbreak in 2019,which constitutes a pandemic.As of March 28,2022,there were 4,76,374,234 confirmed cases and 6,108,976 confimed deaths globally,which ser...Coronavirus disease 2019(COVID-19)has spread rapidly since its outbreak in 2019,which constitutes a pandemic.As of March 28,2022,there were 4,76,374,234 confirmed cases and 6,108,976 confimed deaths globally,which seriously threat-ened human life and health[1].COVID-19,declared a pandemic by The World Health Organization(WHO),is one of the greatest challenges the world has faced for centuries.展开更多
基金supported by the National Natural Science Foundation of China(81973837)Scientific and technological innovation project of China Academy of Chinese Medical Sciences(CI2021A016)National Key projects for international cooperation on science,technology and innovation(2021YFE0201100).
文摘Interactions between diet and the intestinal microbiome play an important role in human health and disease development.It is well known that such interactions,whether direct or indirect,trigger a series of metabolic reactions in the body.Evidence suggests that intestinal stem cells(ISCs),which are phenotypic precursors of various intestinal epithelial cells,play a significant role in the regulation of intestinal barrier function and homeostasis.The advent and evolution of intestinal organoid culture techniques have presented a key opportunity to study the association between the intestinal microenvironment and ISCs.As a result,the effects exerted by dietary factors,intestinal microbiomes,and their metabolites on the metabolic regulation of ISCs and the potential mechanisms underlying such effects are being gradually revealed.This review summarises the effects of different dietary patterns on the behaviour and functioning of ISCs and focuses on the crosstalk between intestinal microbiota,related metabolites,and ISCs,with the aim of fully understanding the relationship between these three factors and providing further insights into the complex mechanisms associated with ISCs in the human body.Gaining an understanding of these mechanisms may lead to the development of novel dietary interventions or drugs conducive to intestinal health.
文摘Coronavirus disease 2019(COVID-19)has spread rapidly since its outbreak in 2019,which constitutes a pandemic.As of March 28,2022,there were 4,76,374,234 confirmed cases and 6,108,976 confimed deaths globally,which seriously threat-ened human life and health[1].COVID-19,declared a pandemic by The World Health Organization(WHO),is one of the greatest challenges the world has faced for centuries.
