The first example for the generation of 2,2,2-trifluoroethylidene ylide from corresponding iodonium salt is reported,which has been successfully applied in the epoxidation of aldehydes,achieving the corresponding tri-...The first example for the generation of 2,2,2-trifluoroethylidene ylide from corresponding iodonium salt is reported,which has been successfully applied in the epoxidation of aldehydes,achieving the corresponding tri-fluoromethylated epoxides in high yields and diastereo-selectivities.展开更多
Herein, we report a simple and efficient method for the direct installation of chlorodifluoroethyl group onto aromatic molecules of various aromatic amides with a new 2-chloro,2,2-difluoroethyl(mesityl)iodonium salt(C...Herein, we report a simple and efficient method for the direct installation of chlorodifluoroethyl group onto aromatic molecules of various aromatic amides with a new 2-chloro,2,2-difluoroethyl(mesityl)iodonium salt(CDFI). Moreover, the chlorodifluoroethyl compounds could be smoothly converted into difluorovinyl compounds in a one-pot or discrete procedure and regarded as a steady source of difluorovinyl compounds with “HCl-mask”.展开更多
基金This work was supported by the National Key Research and Development Program of China(No.2016YFB0401400)the National Natural Science Foundation of China(Nos.21871158 and 21672120)the Fok Ying Tong Education Foundation of China(No.151014).
文摘The first example for the generation of 2,2,2-trifluoroethylidene ylide from corresponding iodonium salt is reported,which has been successfully applied in the epoxidation of aldehydes,achieving the corresponding tri-fluoromethylated epoxides in high yields and diastereo-selectivities.
基金supported by the National Key Research and Development Program of China (No. 2016YFB0401400)the National Natural Science Foundation of China (Nos. 22071129, 21871158 and21672120)。
文摘Herein, we report a simple and efficient method for the direct installation of chlorodifluoroethyl group onto aromatic molecules of various aromatic amides with a new 2-chloro,2,2-difluoroethyl(mesityl)iodonium salt(CDFI). Moreover, the chlorodifluoroethyl compounds could be smoothly converted into difluorovinyl compounds in a one-pot or discrete procedure and regarded as a steady source of difluorovinyl compounds with “HCl-mask”.
