New developments of HIF injector

The ultra-high intensity heavy-ion beam is highly pursued for heavy-ion researches and applications.However,it is limited by heavy-ion production of ion source and space-charge-effect in the low energy region.The Heavy-ion Inertial Fusion(HIF)facilities were proposed in 1970s.The HIF injectors have large cavity number and long total length,e.g.,there are 27 injectors in HIDIF and HIBLIC is 30 km in length,and the corresponding HIF facilities are too large and too expensive to be constructed.Recently,ion acceleration technologies have been developing rapidly,especially in the low energy region,where the acceleration of high intensity heavy-ions is realized.Meanwhile,super-conducting(SC)acceleration matures and increases the acceleration gradient in medium and high energy regions.The length of HIF injectors can be shortened to a buildable length of 2.5 km.This paper will present a review of a renewed HIF injector,which adopts multi-beam linac-based cavities.

Uplift and exhumation in the Tianshan,western China:New insights from detrital zircon morphology and thermochronology

The Tianshan in western China is rich in ore resources,but its tectonic uplift and exhumation history closely related to the resource exploration is still controversial.This study provides a new strategy to uncover the tectonic uplift processes in southern Tianshan by combining the morphological characteristics and thermochronological ages of detrital zircons in the Tarim Basin.The morphology of the Meso-Cenozoic detrital zircons in the Kuqa Foreland Basin,a secondary tectonic unit of the Tarim Basin,is dominated by three types of P,S,and G,and their average alkaline and temperature indexes are 668.0-677.2 and 347.6-413.5,respectively.Moreover,the U-Pb ages of these detrital zircons are primarily divided into two groups of 270-330 and 380-470 Ma.These features indicate that the Early Carboniferous-Early Permian and Middle Ordovician-Middle Devonian alkaline granites distributed in the South Tianshan and southern Central Tianshan were the main sources of the detrital zircons in the Kuqa Foreland Basin.The decomposition of the detrital zircon fission track ages further reveals that the provenances of the Kuqa Foreland Basin primarily consisted of the southern Central Tianshan,the eastern South Tianshan,and the central South Tianshan during Meso-Cenozoic.Among them,the eastern South Tianshan played a dominant role in the material supply.The synthesis of the decomposed zircon fission track(ZFT)ages and the lag-time evolution pattern indicated that the South Tianshan and the southern Central Tianshan mainly experienced five stages of tectonic uplifting that occurred in the Devonian,the Permian,the Middle Triassic-Middle Jurassic,the Cretaceous,and since the Miocene,respectively.They were related to the subduction of the South Tianshan Ocean northward to the bottom of the Central Tianshan,the compression and accretion after the closure of the South Tianshan Ocean,and a series of collisions between the Qiangtang-Lassa-India plates and the southern margin of the Eurasia plate in the Meso-Cenozoic,respectively.This study provides a new provenance analysis method,which was successfully applied in the Tianshan,and also develops a new way to study Central Asia’s tectonic evolution.

新型争论贪噬菌Variovorax paradoxus S110的细胞色素P450酶的异源表达及催化特性分析

细胞色素P450单加氧酶(Cytochrome P450 monooxygenases)是一种广谱催化剂,可以催化多种类型反应而参与生物体外源物质代谢与天然产物的合成。为丰富P450作为合成生物学的酶元件库,并探索新型催化反应,利用生物信息学手段从争论贪噬菌Variovorax paradoxus S110中挖掘出一种新型电子自供体细胞色素P45(VpMO)单加氧酶,属于CYP116B家族,它可以在大肠杆菌Escherichia coli异源可溶表达。酶学性质研究表明P450VpMO最适pH和最适温度分别为8.0和45℃,并且在温度低于35℃时具有良好的稳定性,Km值为0.458 mmol/L,kcat为2.438 min-1;重要的是重组P450VpMO可以催化一系列包含污染物的含甲氧基底物进行脱甲基反应,其中对4-甲氧基苯乙酮的脱甲基反应转化率高达91%。相比于其他CYP116B家族的P450酶,P450VpMO表现出较强的酶活性,这为后期进一步研究P450VpMO提供了基础。