Ovarian cancer is one of the most common malignant tumors of the female repro-ductive system.The majority of patients with advanced ovarian cancer are mainly treated with cisplatin-based chemotherapy.As the most widel...Ovarian cancer is one of the most common malignant tumors of the female repro-ductive system.The majority of patients with advanced ovarian cancer are mainly treated with cisplatin-based chemotherapy.As the most widely used first-line anti-neoplastic drug,cisplatin produces therapeutic effects through multiple mechanisms.However,during clinical treat-ment,cisplatin resistance has gradually emerged,representing a challenge for patient outcome improvement.The mechanism of cisplatin resistance,while known to be complex and involve many processes,remains unclear.We hope to provide a new direction for pre-clin-ical and clinical studies through this review on the mechanism of ovarian cancer cisplatin resis-tance and methods to overcome drug resistance.展开更多
基金supported by the National Natural Science Foundation of China (No.82104448)the Key Research Project of Traditional Chinese Medicine in Zhejiang Province,China (No.2022ZZ008).
文摘Ovarian cancer is one of the most common malignant tumors of the female repro-ductive system.The majority of patients with advanced ovarian cancer are mainly treated with cisplatin-based chemotherapy.As the most widely used first-line anti-neoplastic drug,cisplatin produces therapeutic effects through multiple mechanisms.However,during clinical treat-ment,cisplatin resistance has gradually emerged,representing a challenge for patient outcome improvement.The mechanism of cisplatin resistance,while known to be complex and involve many processes,remains unclear.We hope to provide a new direction for pre-clin-ical and clinical studies through this review on the mechanism of ovarian cancer cisplatin resis-tance and methods to overcome drug resistance.
