The diameter factor of aligned membranes facilitates wound healing by promoting epithelialization in an immune way

Topographical properties,such as pattern and diameter,of biomaterials play important roles in influencing cell activities and manipulating the related immune response during wound healing.We prepared aligned electrospinning membranes with different fiber diameters,including 319±100 nm(A300),588±132 nm(A600),and 1048±130 nm(A1000),by adjusting the distance from the tip to the collector,the injection rate,and the concentration of the solution.The A300 membranes significantly improved cell proliferation and spreading and facilitated wound healing(epithelization and vascularization)with the regeneration of immature hair follicles compared to the other membranes.Transcriptomics revealed the underlying molecular mechanism that A300 could promote immune-related processes towards a pro-healing direction,significantly promoting keratinocyte migration and skin wound healing.All the results indicated that wound healing requires the active participation of the immune process,and that A300 was a potential candidate for guided skin regeneration applications.

蛛网膜囊肿合并脑内血肿一例报道并文献复习

颅内蛛网膜囊肿(intracranial arachnoid cyst,IAC)约占所有颅内占位性病变的1%[1]。IAC合并颅内出血是指IAC患者因某些原因出现与IAC部位相关联的颅内出血,临床上较少见,但因IAC的存在而有其特殊性和复杂性[2-3]。引起此类颅内出血的因素不尽相同,出血部位呈现多样化,其中关于IAC合并脑内血肿的报道少有。而且目前对该类颅内出血的研究报道多以某一部位出血为主,缺乏整体认识[4]。从整体上对IAC合并颅内出血进行分型,有利于深化研究、指导治疗。解放军第九六〇医院神经外科收治了1例外伤致额颞部蛛网膜囊肿合并脑内血肿患者,进一步丰富了IAC合并颅内出血的部位类型,结合该病例并复习国内外相关文献,将IAC合并颅内出血进行总结分型,并对其发病机制及治疗方法进行探讨。