The tribological behavior of AlCr_(0.5)NbTa_(x)Ti_(4-x)(x=0,0.5,and 1)refractory high-entropy alloys was systematically investigated from room temperature to 800℃.The relationship between the alloy composition,micros...The tribological behavior of AlCr_(0.5)NbTa_(x)Ti_(4-x)(x=0,0.5,and 1)refractory high-entropy alloys was systematically investigated from room temperature to 800℃.The relationship between the alloy composition,microstructure,mechanical properties,and tribological performance was analyzed.The results show that all three alloys have a body-centered cubic(bcc)single-phase structure.The Ta addition enhances solid solution strengthening and increases the melting point that would resist high-temperature thermal softening.As a result,high-temperature strength is enhanced considerably,the coefficients of friction(COF)and wear rates of the alloys are reduced considerably at elevated temperatures,demonstrating excellent friction-reducing and anti-wear properties,e.g.,the COF and wear rate of AlCr_(0.5) NbTaTi_(3) alloy at 800℃ are 0.34 and 4.40×10^(-7) mm^(3) N^(-1) m^(-1),respectively.The excellent wear resistance at high temperatures can be attributed to the formation of an oxide-tribo layer(Ta_(2)O_(5) and TiO_(2))with ultrafine-grained layers and good high-temperature mechanical properties.展开更多
This paper presents a coordinated secondary control(CSC)strategy for distributed power management for an autonomous hybrid three-port AC/DC/DS microgrid.The proposed CSC is on top of a generalized primary control(GPC)...This paper presents a coordinated secondary control(CSC)strategy for distributed power management for an autonomous hybrid three-port AC/DC/DS microgrid.The proposed CSC is on top of a generalized primary control(GPC),which consists of local power sharing(LPS)control within an individual AC or DC subgrid,global power sharing(GPS)control throughout the AC/DC subgrids,and storage power sharing(SPS)control in a distributed storage(DS)network.The CSC along with the GPC uses the local frequency/voltage deviations and offers decentralized power management with enhanced overall reliability.To eliminate the inherent frequency/voltage deviations in GPC and restore to their nominal values,a secondary control is normally applied to all distributed generators(DGs),which would degrade the performance of decentralized power management.To overcome this concern,a CSC strategy is proposed to concurrently restore frequency/voltage and re-establish a distributed power management by means of limited information exchange through the low-bandwidth communication links.The proposed control scheme has been verified by both simulations and controller hardware-in-the-loop(CHIL)experiments in an OPAL-RT digital simulator system.展开更多
The mechanical properties and deformation mechanism of a C-doped interstitial high-entropy alloy(i HEA)with a nominal composition of Fe_(49.5)Mn_(29.7)Co_(9.9)Cr_(9.9)C_(1)(at.%)were investigated.An excellent combinat...The mechanical properties and deformation mechanism of a C-doped interstitial high-entropy alloy(i HEA)with a nominal composition of Fe_(49.5)Mn_(29.7)Co_(9.9)Cr_(9.9)C_(1)(at.%)were investigated.An excellent combination of strength and ductility was obtained by cold rolling and annealing.The structure of the alloy is consisted of FCC matrix and randomly distributed Cr_(23)C_(6).For gaining a better understanding of deformation mechanism,EBSD and TEM were conducted to characterize the microstructure of tensile specimens interrupted at different strains.At low strain(2%),deformation is dominated by dislocations and their partial slip.With the strain increase to 20%,deformation-driven athermal phase transformation and dislocations slip are the main deformation mechanism.While at high strain of 35%before necking,deformation twins have been observed besides the HCP phase.The simultaneous effect of phase transformation(TRIP effect)and mechanical twins(TWIP effect)delay the shrinkage,and improve the tensile strength and plasticity.What's more,compared with the HEA without C addition,the yield strength of the C-doped i HEA has been improved,which can be attributed to the grain refinement strengthening and precipitation hardening.Together with the lattice friction and solid solution strengthening,the theoretical calculated values of yield strength match well with the experimental results.展开更多
The influence of cooling rate on microstructural evolution and precipitation behavior in Ti,Ti–Nb and Ti-Mo low-carbon steels during the continuous cooling process was studied by dilatometer method,optical microscopy...The influence of cooling rate on microstructural evolution and precipitation behavior in Ti,Ti–Nb and Ti-Mo low-carbon steels during the continuous cooling process was studied by dilatometer method,optical microscopy,and transmission electron microscopy.The results indicated that austenite transformation temperature decreased with the increasing cooling rate in three steels.The addition of Nb and Mo promoted bainite and martensite transformation and improved the hardenability of steels.In addition,precipitates formed in deformed austenite and ferrite can be observed simultaneously.Deformation in the austenite non-recrystallization zone can introduce a large number of deformation bands,and then,the precipitates preferentially nucleated in these deformation bands.In the following process,randomly distributed precipitates and interphase precipitates will be formed in ferrite.The precipitates formed in deformed austenite obey Kurdjumov-Sachs orientation relationship with the matrix,while the precipitates formed in ferrite obey Baker-Nutting orientation relationship with the matrix.The addition of Nb and Mo in Ti-bearing steels decreased the precipitates size and increased the number density of precipitates and then improved the precipitation hardening.And the effect of Mo addition is more obvious than that of Nb addition.展开更多
Excessive fructose diet is closely associated with colorectal cancer(CRC)progression.Nevertheless,fructose’s specific function and precise mechanism in colorectal cancer liver metastasis(CRLM)is rarely known.Here,thi...Excessive fructose diet is closely associated with colorectal cancer(CRC)progression.Nevertheless,fructose’s specific function and precise mechanism in colorectal cancer liver metastasis(CRLM)is rarely known.Here,this study reported that the fructose absorbed by primary colorectal cancer could accelerate CRLM,and the expression of KHK-A,not KHK-C,in liver metastasis was higher than in paired primary tumors.Furthermore,KHK-A facilitated fructose-dependent CRLM in vitro and in vivo by phosphorylating PKM2 at Ser37.PKM2 phosphorylated by KHK-A inhibited its tetramer formation and pyruvic acid kinase activity but promoted the nuclear accumulation of PKM2.EMT and aerobic glycolysis activated by nuclear PKM2 enhance CRC cells’migration ability and anoikis resistance during CRLM progression.TEPP-46 treatment,targeting the phosphorylation of PKM2,inhibited the pro-metastatic effect of KHK-A.Besides,c-myc activated by nuclear PKM2 promotes alternative splicing of KHK-A,forming a positive feedback loop.展开更多
基金support from the National Key Research and Development Program(No.2022YFB3705300)National Natural Science Foundation of China(Grant No.52004224)Fundamental Research Funds for the Central Universities of China(No.3102019JC001).
文摘The tribological behavior of AlCr_(0.5)NbTa_(x)Ti_(4-x)(x=0,0.5,and 1)refractory high-entropy alloys was systematically investigated from room temperature to 800℃.The relationship between the alloy composition,microstructure,mechanical properties,and tribological performance was analyzed.The results show that all three alloys have a body-centered cubic(bcc)single-phase structure.The Ta addition enhances solid solution strengthening and increases the melting point that would resist high-temperature thermal softening.As a result,high-temperature strength is enhanced considerably,the coefficients of friction(COF)and wear rates of the alloys are reduced considerably at elevated temperatures,demonstrating excellent friction-reducing and anti-wear properties,e.g.,the COF and wear rate of AlCr_(0.5) NbTaTi_(3) alloy at 800℃ are 0.34 and 4.40×10^(-7) mm^(3) N^(-1) m^(-1),respectively.The excellent wear resistance at high temperatures can be attributed to the formation of an oxide-tribo layer(Ta_(2)O_(5) and TiO_(2))with ultrafine-grained layers and good high-temperature mechanical properties.
基金This work was supported in part by the National Research Foundation(NRF)Singapore under Grant S14-1186-NRFEIRP-IHL.
文摘This paper presents a coordinated secondary control(CSC)strategy for distributed power management for an autonomous hybrid three-port AC/DC/DS microgrid.The proposed CSC is on top of a generalized primary control(GPC),which consists of local power sharing(LPS)control within an individual AC or DC subgrid,global power sharing(GPS)control throughout the AC/DC subgrids,and storage power sharing(SPS)control in a distributed storage(DS)network.The CSC along with the GPC uses the local frequency/voltage deviations and offers decentralized power management with enhanced overall reliability.To eliminate the inherent frequency/voltage deviations in GPC and restore to their nominal values,a secondary control is normally applied to all distributed generators(DGs),which would degrade the performance of decentralized power management.To overcome this concern,a CSC strategy is proposed to concurrently restore frequency/voltage and re-establish a distributed power management by means of limited information exchange through the low-bandwidth communication links.The proposed control scheme has been verified by both simulations and controller hardware-in-the-loop(CHIL)experiments in an OPAL-RT digital simulator system.
基金supported by the National Natural Science Foundation of China(Grant No.52004224)the Fundamental Research Funds for the Central Universities(D5000200031)China Postdoctoral Science Foundation(2020M683559)。
文摘The mechanical properties and deformation mechanism of a C-doped interstitial high-entropy alloy(i HEA)with a nominal composition of Fe_(49.5)Mn_(29.7)Co_(9.9)Cr_(9.9)C_(1)(at.%)were investigated.An excellent combination of strength and ductility was obtained by cold rolling and annealing.The structure of the alloy is consisted of FCC matrix and randomly distributed Cr_(23)C_(6).For gaining a better understanding of deformation mechanism,EBSD and TEM were conducted to characterize the microstructure of tensile specimens interrupted at different strains.At low strain(2%),deformation is dominated by dislocations and their partial slip.With the strain increase to 20%,deformation-driven athermal phase transformation and dislocations slip are the main deformation mechanism.While at high strain of 35%before necking,deformation twins have been observed besides the HCP phase.The simultaneous effect of phase transformation(TRIP effect)and mechanical twins(TWIP effect)delay the shrinkage,and improve the tensile strength and plasticity.What's more,compared with the HEA without C addition,the yield strength of the C-doped i HEA has been improved,which can be attributed to the grain refinement strengthening and precipitation hardening.Together with the lattice friction and solid solution strengthening,the theoretical calculated values of yield strength match well with the experimental results.
基金supported by the National Natural Science Foundation of China(Grant No.52004224)the Fundamental Research Funds for the Central Universities(No.D5000200031)China Postdoctoral Science Foundation(2020M683559).
文摘The influence of cooling rate on microstructural evolution and precipitation behavior in Ti,Ti–Nb and Ti-Mo low-carbon steels during the continuous cooling process was studied by dilatometer method,optical microscopy,and transmission electron microscopy.The results indicated that austenite transformation temperature decreased with the increasing cooling rate in three steels.The addition of Nb and Mo promoted bainite and martensite transformation and improved the hardenability of steels.In addition,precipitates formed in deformed austenite and ferrite can be observed simultaneously.Deformation in the austenite non-recrystallization zone can introduce a large number of deformation bands,and then,the precipitates preferentially nucleated in these deformation bands.In the following process,randomly distributed precipitates and interphase precipitates will be formed in ferrite.The precipitates formed in deformed austenite obey Kurdjumov-Sachs orientation relationship with the matrix,while the precipitates formed in ferrite obey Baker-Nutting orientation relationship with the matrix.The addition of Nb and Mo in Ti-bearing steels decreased the precipitates size and increased the number density of precipitates and then improved the precipitation hardening.And the effect of Mo addition is more obvious than that of Nb addition.
基金funded by the National Natural Science Foundation(Grant Number 82273406)Basic Research Program of Jiangsu Province(Grant No.BK20201491,China)+2 种基金Nature Key Research and Development Program of Jiangsu Province(BE2021742,China)Jiangsu Province Capability Improvement Project through Science,Technology and Education(Jiangsu Provincial Medical Key Discipline,ZDXK202222,China)the National Natural Science Foundation(Grant Number 82203656,China).
文摘Excessive fructose diet is closely associated with colorectal cancer(CRC)progression.Nevertheless,fructose’s specific function and precise mechanism in colorectal cancer liver metastasis(CRLM)is rarely known.Here,this study reported that the fructose absorbed by primary colorectal cancer could accelerate CRLM,and the expression of KHK-A,not KHK-C,in liver metastasis was higher than in paired primary tumors.Furthermore,KHK-A facilitated fructose-dependent CRLM in vitro and in vivo by phosphorylating PKM2 at Ser37.PKM2 phosphorylated by KHK-A inhibited its tetramer formation and pyruvic acid kinase activity but promoted the nuclear accumulation of PKM2.EMT and aerobic glycolysis activated by nuclear PKM2 enhance CRC cells’migration ability and anoikis resistance during CRLM progression.TEPP-46 treatment,targeting the phosphorylation of PKM2,inhibited the pro-metastatic effect of KHK-A.Besides,c-myc activated by nuclear PKM2 promotes alternative splicing of KHK-A,forming a positive feedback loop.