Neurodegenerative disorders represent a pervasive global health challenge,yet therapeutic options remain conspicuously limited.These disorders are inherently dynamic processes within the central nervous system,unfoldi...Neurodegenerative disorders represent a pervasive global health challenge,yet therapeutic options remain conspicuously limited.These disorders are inherently dynamic processes within the central nervous system,unfolding across distinct sub-stages:initial structural neuronal alterations(sub-stage 1),functional impairment(sub-stage 2),and culminating in neuronal death(sub-stage 3).展开更多
In a paper published in Nature,Park and colleagues have explored an innovative approach for improving adoptive neuron transfer,with possible implications for Parkinson´s Disease(PD)and other neurodegenerative dis...In a paper published in Nature,Park and colleagues have explored an innovative approach for improving adoptive neuron transfer,with possible implications for Parkinson´s Disease(PD)and other neurodegenerative diseases.1 By co-transplanting autologous regulatory T(Treg)cells,they managed to reduce surgical trauma-induced neuroinflammation,enhance the safety of cell replacement therapy by inhibiting proliferation of non-dopaminergic cells and improve therapeutic outcomes.展开更多
基金supported by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)Project-ID 424778381-TRR 295 and the Fondazione Grigioni per il Morbo di Parkinson(to MM).
文摘Neurodegenerative disorders represent a pervasive global health challenge,yet therapeutic options remain conspicuously limited.These disorders are inherently dynamic processes within the central nervous system,unfolding across distinct sub-stages:initial structural neuronal alterations(sub-stage 1),functional impairment(sub-stage 2),and culminating in neuronal death(sub-stage 3).
基金supported by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)Project-ID 424778381-TRR 295(A06,to C.W.I.)the Inter-disciplinary Center for Clinical Research(IZKF)at the University of Würzburg(A-421,to C.W.I.and J.W.)+1 种基金the VERUM Foundation(to C.W.I.)This publication was supported by the Open Access Publication Fund of the University of Würzburg。
文摘In a paper published in Nature,Park and colleagues have explored an innovative approach for improving adoptive neuron transfer,with possible implications for Parkinson´s Disease(PD)and other neurodegenerative diseases.1 By co-transplanting autologous regulatory T(Treg)cells,they managed to reduce surgical trauma-induced neuroinflammation,enhance the safety of cell replacement therapy by inhibiting proliferation of non-dopaminergic cells and improve therapeutic outcomes.
