Association between metabolic factors and chronic hepatitis B virus infection

There are limited data regarding the relationship between chronic hepatitis B virus(HBV)infection and metabolic factors.This article aims to highlight the link of metabolic factors with hepatitis B surface antigen(HBsAg)serostatus,HBV load,and HBV-related hepatocellular carcinoma(HCC).Although HBsAg-positive serostatus was positively correlated with a high risk of metabolic syndrome in students,chronic HBV-infected individuals have high serum adiponectin levels.The androgen pathway in HBV carriers with a low body mass index is more triggered which leads to enhanced HBV replication.High HBV load was inversely associated with obesity in hepatitis B e antigen(HBeAg)-seropositive HBV carriers;while in HBeAg-seronegative HBV carriers,high HBV load was inversely related to hypertriglyceridemia rather than obesity.For overweight and obese HBV-infected patients,high HBV load was positively associated with serum adiponectin levels.Several large cohort studies have revealed a positive link of diabetes with incidence of HBV-related HCC.However,the association between incidence of HCC and metabolic factors other than diabetes is still inconclusive.More long-term prospective studies should elucidate the association of chronic HBV infection and its outcomes with metabolic factors in clinical practice.

Diabetes and hepatocellular carcinoma risks in patients with nonalcoholic steatohepatitis related cirrhosis

Hepatocellular carcinoma(HCC)oncogenesis in the absence of alcoholic liver disease and chronic viral hepatitis has aroused growing clinical concern in clinical practice.