AIM:To determine the effect of body mass index(BMI) on the characteristics and overall outcome of colon cancer in Taiwan.METHODS:From January 1995 to July 2003,2138 patients with colon cancer were enrolled in this stu...AIM:To determine the effect of body mass index(BMI) on the characteristics and overall outcome of colon cancer in Taiwan.METHODS:From January 1995 to July 2003,2138 patients with colon cancer were enrolled in this study.BMI categories(in kg/m 2) were established according to the classification of the Department of Health of Taiwan.Postoperative morbidities and mortality,and survival analysis including overall survival(OS),diseasefree survival(DFS),and cancer-specific survival(CSS) were compared across the BMI categories.RESULTS:There were 164(7.7%) underweight(BMI < 18.5 kg/m 2),1109(51.9%) normal-weight(BMI = 18.5-23.9 kg/m 2),550(25.7%) overweight(BMI = 24.0-26.9 kg/m 2),and 315(14.7%) obese(BMI ≥27 kg/m 2) patients.Being female,apparently anemic,hypoalbuminemic,and having body weight loss was more likely among underweight patients than among the other patients(P < 0.001).Underweight patients had higher mortality rate(P = 0.007) and lower OS(P < 0.001) and DFS(P = 0.002) than the other patients.OS and DFS did not differ significantly between normal-weight,overweight,and obese patients,while CSS did not differ significantly with the BMI category.CONCLUSION:In Taiwan,BMI does not significantly affect colon-CSS.Underweight patients had a higher rate of surgical mortality and a worse OS and DFS than the other patients.Obesity does not predict a worse survival.展开更多
文摘AIM:To determine the effect of body mass index(BMI) on the characteristics and overall outcome of colon cancer in Taiwan.METHODS:From January 1995 to July 2003,2138 patients with colon cancer were enrolled in this study.BMI categories(in kg/m 2) were established according to the classification of the Department of Health of Taiwan.Postoperative morbidities and mortality,and survival analysis including overall survival(OS),diseasefree survival(DFS),and cancer-specific survival(CSS) were compared across the BMI categories.RESULTS:There were 164(7.7%) underweight(BMI < 18.5 kg/m 2),1109(51.9%) normal-weight(BMI = 18.5-23.9 kg/m 2),550(25.7%) overweight(BMI = 24.0-26.9 kg/m 2),and 315(14.7%) obese(BMI ≥27 kg/m 2) patients.Being female,apparently anemic,hypoalbuminemic,and having body weight loss was more likely among underweight patients than among the other patients(P < 0.001).Underweight patients had higher mortality rate(P = 0.007) and lower OS(P < 0.001) and DFS(P = 0.002) than the other patients.OS and DFS did not differ significantly between normal-weight,overweight,and obese patients,while CSS did not differ significantly with the BMI category.CONCLUSION:In Taiwan,BMI does not significantly affect colon-CSS.Underweight patients had a higher rate of surgical mortality and a worse OS and DFS than the other patients.Obesity does not predict a worse survival.
