Untreated human immunodeficiency virus(HIV)infections usually lead to death from AIDS,although the rate of the disease progression varies widely among individuals.The cytotoxic T lymphocyte(CTL)response,which is restr...Untreated human immunodeficiency virus(HIV)infections usually lead to death from AIDS,although the rate of the disease progression varies widely among individuals.The cytotoxic T lymphocyte(CTL)response,which is restricted by highly polymorphic MHC class I alleles,plays a central role in controlling HIV replication.It is now recognized that the antiviral efficacy of CTLs at the single cell level is dependent on their antigen specificity and is important in determining the quality of host response to viruses so that the individual will remain asymptomatic.However,because of the extreme mutational plasticity of HIV,HIV-specific CTL responses are continuously and dynamically changing.In order to rationally design an effective vaccine,the questions as to what constitutes an effective antiviral CTL response and what characterizes a potent antigenic peptide to induce such responses are becoming highlighted as needing to be answered.展开更多
基金This research was supported in part by a grant-in-aid for scientific research from the Ministry of Education,Science,Sports,and Culture of Japan,by a grant from Human Science Foundation,and by a grantin-aid for AIDS research from the Ministry of Health,Labor,and Welfare of Japan.
文摘Untreated human immunodeficiency virus(HIV)infections usually lead to death from AIDS,although the rate of the disease progression varies widely among individuals.The cytotoxic T lymphocyte(CTL)response,which is restricted by highly polymorphic MHC class I alleles,plays a central role in controlling HIV replication.It is now recognized that the antiviral efficacy of CTLs at the single cell level is dependent on their antigen specificity and is important in determining the quality of host response to viruses so that the individual will remain asymptomatic.However,because of the extreme mutational plasticity of HIV,HIV-specific CTL responses are continuously and dynamically changing.In order to rationally design an effective vaccine,the questions as to what constitutes an effective antiviral CTL response and what characterizes a potent antigenic peptide to induce such responses are becoming highlighted as needing to be answered.
