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Hepcidin-25 negatively predicts left ventricular mass index in chronic kidney disease patients 被引量:1
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作者 Yao-Peng Hsieh Ching-Hui Huang +3 位作者 Chia-Ying Lee Hung-lin Chen ching-yuang lin Chia-Chu Chang 《World Journal of Nephrology》 2013年第2期38-43,共6页
AIM: To assess the correlation between the serum hep-cidin-25 level and left ventricular mass index.METHODS: This study was a cross-sectional study conducted between March 2009 and April 2010. Demo-graphic and bioch... AIM: To assess the correlation between the serum hep-cidin-25 level and left ventricular mass index.METHODS: This study was a cross-sectional study conducted between March 2009 and April 2010. Demo-graphic and biochemical data, including the serum hep-cidin-25 level, were collected for chronic kidney disease (CKD) patients. Two-dimensional echocardiography was performed to determine the left ventricle mass (LVM), left ventricular mass index (LVMI), interventricular septum thickness (IVSd), left ventricle posterior wall thickness (LVPW), right ventricular dimension (RVD), left atrium (LA) and ejection fraction (EF).RESULTS: A total of 146 patients with stage 1 to 5 CKD were enrolled. Serum hepcidin-25 levels were 16.51 ± 5.2, 17.59 ± 5.32, 17.38 ± 6.47, 19.98 ± 4.98 and 22.03 ± 4.8 ng/mL for stage 1 to 5 CKD patients, respectively. Hepcidin-25 level was independently pre-dicted by the serum ferritin level (β = 0.6, P = 0.002) and the estimated glomerular fltration rate (β = -0.48, P = 0.04). There were negative correlations between the serum hepcidin level and the LVM and LVMI ( P = 0.04 and P = 0.005, respectively). Systolic blood pressure (BP) was positively correlated with the LVMI ( P = 0.005). In the multivariate analysis, a decreased serum hepci-din-25 level was independently associated with a higher LVMI (β = -0.28, 95%CI: -0.48 - -0.02, P = 0.006) after adjusting for body mass index, age and systolic BP.CONCLUSION: A lower serum hepcidin level is associ-ated with a higher LVMI in CKD patients. Low hepcidin levels may be independently correlated with unfavor-able cardiovascular outcomes in this population. 展开更多
关键词 Hepcidin-25 FERRITIN Chronic kidney disease Left ventricular mass Left ventricular mass index
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IgA肾病患儿治疗的研究进展 被引量:1
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作者 James C. M. Chan Man-Chun Chiu +3 位作者 Satoshi Hisano ching-yuang lin 管娜(翻译) 丁洁(审校) 《中华儿科杂志》 CAS CSCD 北大核心 2007年第4期244-247,共4页
1968年IgA肾病首次被描述,最初称为Berger病。先证者为法国患儿,表现为急性上呼吸道感染数天后出现无症状肉眼血尿。肾活检显示系膜区显著扩大、IgA沉积,因此被命名为IgA肾病。此后40年临床治疗实践中,对该病自然病程了解逐渐增多... 1968年IgA肾病首次被描述,最初称为Berger病。先证者为法国患儿,表现为急性上呼吸道感染数天后出现无症状肉眼血尿。肾活检显示系膜区显著扩大、IgA沉积,因此被命名为IgA肾病。此后40年临床治疗实践中,对该病自然病程了解逐渐增多,但对其发病机制知之甚少。20世纪80年代,D,Amico和其他学者已经认识到IgA肾病是世界上最常见的肾小球肾炎。因此,Julian等指出该病对1%以上的人口有影响。 展开更多
关键词 IgA肾病 临床治疗 患儿 急性上呼吸道感染 IGA沉积 肾小球肾炎 肉眼血尿 自然病程
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