Kinsenoside:A Promising Bioactive Compound from Anoectochilus Species

Kinsenoside is a main active component isolated from plants of the genus Anoectochilus,and exhibits many biological activities and pharmacological effects,including hepatoprotective,anti-hyperglycemic,anti-hyperliposis,anti-inflammatory,vascular protective and anti-osteoporosis effects and so on,which is contributing to its promising potency in disease treatments.This review aims to recapitulate the pharmacological functions of kinsenoside,as well as its source,extraction,identification,quantitative analysis,pharmacokinetics,synthesis and patent information.The data reported in this work can confirm the therapeutic potential of kinsenoside and provide useful information for further new drug development.

Polysubstituted Phenyl Glucosides Produced by the Fungus Metarrhizium anisopliae

MetarhizosidesA-G(1-7),seven new polysubstituted phenyl glucosides,were isolated from the extracts of solid rice medium of a marine-derived fungus Metarrhizium anisopliae.Compounds 1-7 all contain a polysubstituted phenyl group and the sugar unit is identified as 4'-O-methyl-β-D-glucopyranose.Their structures were elucidated by NMR spectroscopy and chemical method.These compounds were evaluated for anti-inflammatory activity by using LPS-stimulated murine macrophage RAW 264.7 cells and the cytotoxicities against four human cancer cell lines.

Erratum to:Polysubstituted Phenyl Glucosides Produced by the Fungus Metarrhizium anisopliae

The article“Polysubstituted Phenyl Glucosides Produced by the Fungus Metarrhizium anisopliae”,written by Wen-jing WANG,Chong DAI,Jian-ping WANG,Hu-cheng ZHU,Chun-mei CHEN,Yong-hui ZHANG,was originally published electronically on the publisher’s internet portal on May 2020 without open access.With the author(s)’decision to opt for Open Choice,the copyright of the article is changed to©The Author(s)2020 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License(https://creativecommons.org/licenses/by/4.0/),which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons license,and indicate if changes were made.

Structural Elucidation and Total Synthesis of Trichodermotin A,A Natural α-Glucosidase Inhibitor from Trichoderma asperellum

A pair of alkaloid enantiomers possessing a novel 1-oxaspiro[4.4]non-3-ene-2,7-dione skeleton,trichodermotin A(1),was obtained from the fungus Trichoderma asperellum.Spectroscopic data,X-ray diffraction,and ECD calculations were used to establish its structure and absolute configuration.(−)-1 showed significantα-glucosidase inhibitory activity(IC_(50)=10.1μmol/L vs.60.1μmol/L of positive control).A plausible biosynthetic pathway originating from L-β-phenylalanine was proposed,and a facile total synthesis was further accomplished.The key reaction of our synthetic strategy was a domino aza-Michael/lactonization in one pot,leading to the pivotal 4-amino-oxaspiro[4.4]octane scaffold.