Immunological disturbance effect of exogenous histamine towards key immune cells

Histamine in food has attracted widespread attention due to the potential toxicity and associated health risk.However,its influences on immunological components,especially the function of key immune cells,are still poorly known.In this work,we explored the effects of exogenous histamine on the function of key immune cells such as intestinal epithelial cells,dendritic cells,and T cells.The results showed that histamine could affect the expression of allergy-related genes in CMT93 cells at a high dose of histamine.Moreover,it’s found that histamine could cause an imbalance in the levels of relevant immune factors secreted by dendritic cells and T cells,especially those related to allergy.At the same time,the proportion of MHC class IIpositive dendritic cells and the proportion of T helper 2(Th2)cells in CD4^(+)T cells increased after histamine stimulation.We concluded that the presence of a certain level of histamine in food may affect the expression of allergy-related cytokines,disrupt the balance of the immune homeostasis,and potentially lead to adverse immune reactions.This work demonstrated the importance of including the estimation of histamine’s immune safety in aquatic products rather than merely considering the potential risk of food poisoning.

3D seismic forward modeling from the multiphysical inversion at the Ketzin CO_(2) storage site

From June 2008 to August 2013,approximately 67 kt of CO_(2) was injected into a deep saline formation at the Ketzin pilot CO_(2) storage site.During injection,3D seismic surveys have been performed to monitor the migration of sequestered CO_(2).Seismic monitoring results are limited by the acquisition and signal-to-noise ratio of the acquired data.The multiphysical reservoir simulation provides information regarding the CO_(2) fluid behavior,and the approximated model should be calibrated with the monitoring results.In this work,property models are delivered from the multiphysical model during 3D repeated seismic surveys.The simulated seismic data based on the models are compared with the real data,and the results validate the effectiveness of the multiphysical inversion method.Time-lapse analysis shows the trend of CO_(2) migration during and after injection.

Parameter optimization for Rayleigh-Mie lidar under different dust conditions for the landing area of Martian Tianwen-1

Mars is the terrestrial planet in the solar system that is closest to the Earth.Studying the atmospheric parameters of Mars and studying the evolutionary history of the Martian environment on this basis is helpful for people to discover signs of extraterrestrial life and to study the trend of climate change on Earth.Mie–Rayleigh scattering lidar is an important technology for detecting parameters from the surface to the middle and upper atmosphere.Because of the different aerosol distributions,Mie scattering and Rayleigh scattering have their own optimal detection ranges.Given the long period and high cost of any deep space exploration program,it is important to conduct sufficient feasibility studies and parameter simulations before the payload is launched.In this study,a parameterized lidar mathematical model and Earth’s atmospheric mode are used to compare with the measured signals of ground-based Mie–Rayleigh scattering lidar,and the correctness of the lidar mathematical model is verified.Using the model,we select the landing area of Tianwen-1 and substitute it into the Martian atmospheric mode,and then the Mie–Rayleigh lidar backscattering signal and the key parameters of the lidar system are systematically analyzed under the conditions of a clean Martian atmosphere and a global sandstorm.In addition,the optimal detection altitude ranges of Mie scattering and Rayleigh scattering on Mars under different atmospheric conditions are obtained,which provides a reference for the practical design and development of the subsequent lidar system for the Martian atmospheric environment.

Oral administration of Bacillus coagulans TQ-35 alleviates allergic responses in OVA-sensitive BALB/c mice

Bacillus coagulans has been extensively studied so far,but there has been a lack of research on its usage in allergy.In this study,we designed to assess the effect of different concentrations of B.coagulans on food allergy in a BALB/c mouse model of ovalbumin(OVA)-induced food allergy and its effect on gut microbes.The assessment of symptoms,specific immunoglobulin E(IgE),T-cell differentiation,and related gene expression levels in sensitized mice by assay indicated that high doses of oral B.coagulans could alleviate allergic symptoms.Treatment with B.coagulans,in the high-dose group,significantly reduced IgE and IgG1 levels and modulated the balance of T helper type 1 cell(Th1)and Th2 and the expression of relevant genes in the spleen.16S rRNA analysis showed that probiotics improved the structure of the microbiota,in particular by boosting the percentage of Clostridia,Bacteroides vulgatus and Enterococcus faecium,and by increasing the abundance of microbial species,thereby modulating the immune system.Therefore,this study can provide insights into the practical application of B.coagulans doses to alleviate OVA allergy.

Higher intakes of lysine,threonine and valine are inversely associated with non-alcoholic fatty liver disease risk:a community-based case-control study in the Chinese elderly

The associations of individual amino acid with non-alcoholic fatty liver disease(NAFLD)risk remained unclear.The present study aimed to investigate the associations between the two in the Chinese elderly.Methods:A community-based health check-up program was conducted in Qingdao,China.NAFLD was diagnosed by ultrasonography accompanied by epidemiological investigation.The dietary intakes of amino acids were investigated with 3-day,24-h dietary records and calculated by Nutrition Calculator software.Restricted cubic spline model was used to evaluate a nonlinear relationship between amino acid intake and NAFLD risk.Results:400 NAFLD subjects were identified,and 400 participants were randomly selected as controls and matched by gender and age(±3 years)Dose-response analysis showed that 1000 mg increment of aromatic amino acids(AAAs)was associated with reduced 16%risk of NAFLD.Dietary increments of 750 mg/d threonine,950 mg/d valine,or 1700 mg/d lysine were associated with a 20%reduction in the NAFLD risk(all P for linearity<0.05).Conclusion:The present study demonstrated that the dietary increases in milk,eggs and deep-sea fish,which are rich in the amino acids,might contribute to protecting against NAFLD in the elderly.

印制电路中电镀铜技术研究及应用

电镀铜技术是制造印制电路板、封装载板等电子互连器件的核心技术。本文介绍了印制电路中电镀铜技术及其发展概况,主要总结了电子科技大学印制电路与印制电子团队在印制电路电镀铜技术基础研究和产业化应用等方面的工作。首先,以三次电流分布理论为基础,采用多物理场耦合方法构建阴极表面轮廓线随时间变化的镀层生长过程模型。该模型描述了铜沉积与微纳孔结构、添加剂特性、输入电流、对流强度等相关影响因素的函数关系。通过引入添加剂相关函数,该模型能够较好应用到整平剂筛选和性能评价、电镀铜需求和镀液配方匹配、电镀参数优化等技术开发和应用领域。然后,介绍了添加剂竞争吸附过程的电化学研究以及利用传质调控添加剂局域浓度实现快速微盲孔、微沟槽填充的工业技术。之后,介绍了氮杂环低聚物系列整平剂结构-电化学构效关系研究和应用。最后展示了氧化还原型添加剂的开发情况,并对印制电路中电镀铜技术的研究和应用发展进行了预测。

Long-lasting growth regulation on cotton using mepiquat chloride adsorbed layered double hydroxide

Mepiquat chloride(1,1-dimethyl piperidinium chloride,DPC)is a representative plant growth regulator which can regulate the source-sink relationship for yield increase and shape ideal plant type for mechanical cultivation.Here we show a DPC adsorbed layered double hydroxide(DPC-LDH)architecture with enhanced controlled release property and soil distribution.By drip irrigation on cotton,it makes total dosage of DPC reduced from 270 to 90 g/ha,while the frequency decreased from 5 to 2 times.The unique supramolecular interaction is confirmed as the basis of controlled release behavior.Moreover,except for the physical resistance to the sedimentation brought by the lamellar LDH,the enhanced electrostatic interaction makes DPC-LDH the dominant distribution in soil.It improves the efficiency of DPC molecules absorbed by cotton plants and greatly saves the inputs in labor and chemicals.This method is expected to achieve the yield increase and agricultural sustainability by energy saving and emission reduction.

论转化型贪污罪中非法占有目的的认定标准

挪用公款转化贪污罪与挪用公款罪从客观上很难区分,主观方面的非法占有目的是区分两罪的关键。对于转化型贪污罪中非法占有目的的认定标准来说,理论上认为关键在于行为人主观上是否具有归还意思,而实践中则主要以行为人的客观表现来具体认定。无论是理论上的主观标准还是实践中的客观标准都存在一定的不足,对于转化型贪污罪中非法占有目的认定应坚持主客观相统一原则。

以服务国家重大战略需求为导向的基础学科专业建设探索和实践——上海交通大学化学(强基计划)专业建设初试

强基计划是基础学科招生改革试点的重要举措。化学专业立足于基础学科拔尖创新人才的选拔和培养,服务国家重大战略需求,发展以化学基础为主、理工交叉的培养模式。全面介绍上海交通大学首届化学(强基计划)专业在育人目标、培养特色和教学体系建设等方面的思考、研究和举措,为强基计划进一步实施提供理论和实践依据。

Roles of neural stem cells in the repair of peripheral nerve injury

Currently, researchers are using neural stem cell transplantation to promote regeneration after peripheral nerve injury, as neural stem cells play an important role in peripheral nerve injury repair. This article reviews recent research progress of the role of neural stem cells in the repair of peripheral nerve injury. Neural stem cells can not only differentiate into neurons, astrocytes and oligodendrocytes, but can also differentiate into Schwann-like cells, which promote neurite outgrowth around the injury. Transplanted neural stem cells can differentiate into motor neurons that innervate muscles and promote the recovery of neurological function. To promote the repair of peripheral nerve injury, neural stem cells secrete various neurotrophic factors, including brain-derived neurotrophic factor, fibroblast growth factor, nerve growth factor, insulin-like growth factor and hepatocyte growth factor. In addition, neural stem cells also promote regeneration of the axonal myelin sheath, angiogenesis, and immune regulation. It can be concluded that neural stem cells promote the repair of peripheral nerve injury through a variety of ways.

A prediction method for the performance of a low-recoil gun with front nozzle

One of the greatest challenges in the design of a gun is to balance muzzle velocity and recoil,especially for guns on aircrafts and deployable vehicles.To resolve the conflict between gun power and recoil force,a concept of rarefaction wave gun(RAVEN)was proposed to significantly reduce the weapon recoil and the heat in barrel,while minimally reducing the muzzle velocity.The main principle of RAVEN is that the rarefaction wave will not reach the projectile base until the muzzle by delaying the venting time of an expansion nozzle at the breech.Developed on the RAVEN principle,the purpose of this paper is to provide an engineering method for predicting the performance of a low-recoil gun with front nozzle.First,a two-dimensional two-phase flow model of interior ballistic during the RAVEN firing cycle was established.Numerical simulation results were compared with the published data to validate the reliability and accuracy.Next,the effects of the vent opening times and locations were investigated to determine the influence rules on the performance of the RAVEN with front nozzle.Then according to the results above,simple nonlinear fitting formulas were provided to explain how the muzzle velocity and the recoil force change with the vent opening time and location.Finally,a better vent venting opening time corresponding to the vent location was proposed.The findings should make an important contribution to the field of engineering applications of the RAVEN.

Risk factors for delayed hemorrhage after endoscopic sphincterotomy

Background:Hemorrhage is one of the most serious complications of endoscopic sphincterotomy(EST).The risk factors for delayed hemorrhage are not clear.This study aimed to explore the risk factors for post-EST delayed hemorrhage and suggest some precautionary measures.Methods:This study analyzed 8477 patients who successfully underwent endoscopic retrograde cholangiopancreatography(ERCP)and EST between January 2007 and June 2015 in the First Affiliated Hospital of Nanchang University.Univariate and multivariate analyses were performed to find the risk factors for delayed hemorrhage after EST.Results:Of the 8477 patients screened,137(1.62%)experienced delayed hemorrhage.Univariate analysis showed that male,the severity of jaundice,duodenal papillary adenoma and carcinoma,diabetes,intraoperative bleeding,moderate and large incisions,and directional deviation of incision were risk factors for post-EST delayed hemorrhage(P<0.05).Multivariate analysis showed that intraoperative bleeding[odds ratio(OR)=3.326;95%CI:1.785–6.196;P<0.001]and directional deviation of incision(OR=2.184;95%CI:1.266–3.767;P=0.005)were independent risk factors for post-EST delayed hemorrhage.Conclusions:Delayed hemorrhage is the most common and dangerous complication of EST.Intraoperative bleeding and directional deviation of incision are independent risk factors for post-EST delayed hemorrhage.

Application of in vitro and in vivo models in the study of food allergy

Food allergy is one of the most important food safety problems that has attracted increasing attention.The food allergy experimental models provide not only the accurate allergen detection and evaluation methods but also the powerful approaches for mechanism investigations.In this paper,we reviewed the common food allergy cell models including mast cell,basophil granulocyte and basophil,as well as the animal models of BALB/c mouse,C3H/HeJ mouse,and BN rat.We also introduced zebrafish,a promising model organism for investigating immunity though lacking direct applications in food allergy to date,and focused on traumatic inflammation,bacterial infection and viral infection models.In addition,we also summarized the clinical diagnostic research methods for food allergy.The elucidation of these topics will help researchers to understand the characteristics and mechanisms of various models and thus select the proper models for particular study,so as to support further investigations of food allergy.

Fuzzy finite difference method for heat conduction analysis with uncertain parameters

A new numerical technique named as fuzzy finite difference method is proposed to solve the heat conduction problems with fuzzy uncertainties in both the phys- ical parameters and initial/boundary conditions. In virtue of the level-cut method, the difference discrete equations with fuzzy parameters are equivalently transformed into groups of interval equations. New stability analysis theory suited to fuzzy difference schemes is developed. Based on the parameter perturbation method, the interval ranges of the uncertain temperature field can be approximately predicted. Subsequently, fuzzy solutions to the original difference equations are obtained by the fuzzy resolution theorem. Two numerical examples are given to demonstrate the feasibility and efficiency of the presented method for solving both steady-state and transient heat conduction problems.

Ore-forming environment of Pb−Zn mineralization related to granite porphyry at Huangshaping skarn deposit,Nanling Range,South China

Multiple metallogenic types(skarn-type and vein-type)related to hypabyssal granites are found at the Huangshaping polymetallic deposit in the Nanling Range,South China.To constrain the crystallization and mineralization processes of skarn formation,three generations of magnetite and pyrrhotite from the hydrous silicate stage,oxide stage,early quartz–sulfide stage,and late quartz–sulfide stage were distinguished.The geochemical compositions of magnetite and pyrrhotite were obtained by electron probe microanalyzer(EPMA)and in-situ ablation-inductively coupled plasma-mass spectrometry(LA‒ICP‒MS).The results show that there may be silicate inclusions in magnetite and interaction of wall rock occurred in the mineralization process.The geochemical trends recorded in pyrrhotite show the influence of limestone during the crystallization of pyrrhotite.The re-equilibration temperatures of Po I,Po II,and Po III are 420.46,380.45,and 341.81°C,respectively,which suggests a continuous evolution following the high-temperature W–Sn mineralized system.The content change of Ni and V reflects a gradual decrease of oxygen fugacity from Mag I to Mag III,while the sulfur fugacity calculated from pyrrhotite gradually decreases.This continuous skarn mineralization evolution process helps us to better understand the change of metallogenic environment in the retrograde stage of the Huangshaping deposit.

Recommendation Algorithm Based on Probabilistic Matrix Factorization with Adaboost

A current problem in diet recommendation systems is the matching of food preferences with nutritional requirements,taking into account individual characteristics,such as body weight with individual health conditions,such as diabetes.Current dietary recommendations employ association rules,content-based collaborative filtering,and constraint-based methods,which have several limitations.These limitations are due to the existence of a special user group and an imbalance of non-simple attributes.Making use of traditional dietary recommendation algorithm researches,we combine the Adaboost classifier with probabilistic matrix factorization.We present a personalized diet recommendation algorithm by taking advantage of probabilistic matrix factorization via Adaboost.A probabilistic matrix factorization method extracts the implicit factors between individual food preferences and nutritional characteristics.From this,we can make use of those features with strong influence while discarding those with little influence.After incorporating these changes into our approach,we evaluated our algorithm’s performance.Our results show that our method performed better than others at matching preferred foods with dietary requirements,benefiting user health as a result.The algorithm fully considers the constraint relationship between users’attributes and nutritional characteristics of foods.Considering many complex factors in our algorithm,the recommended food result set meets both health standards and users’dietary preferences.A comparison of our algorithm with others demonstrated that our method offers high accuracy and interpretability.

恩沙替尼治疗EML4-ALK/TP53共突变肺鳞癌1例并文献复习

肺鳞癌约占非小细胞肺癌(non-small cell lung cancer,NSCLC)的30%,是第二常见的肺癌组织学类型。具有间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)融合突变的NSCLC仅占所有NSCLC病例的2%-5%,且几乎只存在于肺腺癌患者中。因此ALK检测在肺鳞癌患者中不常规进行,个别见于报道的ALK融合突变肺鳞癌患者的靶向治疗效果也不清楚。本例晚期肺鳞癌患者通过二代测序发现存在棘皮动物微管相关蛋白样4(echinoderm microtubule associated protein like 4,EML4)-ALK(V1)和TP53共突变,2020年12月3日开始口服恩沙替尼,疗效评价为部分缓解(partial response,PR),无进展生存期(progression-free survival,PFS)达19个月,疾病进展后改为洛拉替尼。其中一线恩沙替尼治疗创造了有文献报道以来ALK突变肺鳞癌患者靶向治疗最长的PFS。本文报道了1例接受恩沙替尼治疗的EML4-ALK和TP53共突变肺鳞癌患者,并回顾相关文献,对此类罕见患者的治疗进行了讨论。

Effect of ultrasonic peening treatment on the fatigue behaviors of a magnesium alloy up to very high cycle regime

Ultrasonic fatigue tests are performed on a magnesium alloy with and without ultrasonic peening treatment(UPT).Surface enhancement layer leads to the complete change of crack initiation sites.However,crack initiation mechanism keeps the same and results in a single-faceted morphology at crack initiation site.Microcracks initiate as Mode Ⅱ crack within the original grain,but deflect to Mode I crack outside of the original cracked grain.A threshold SIF value is proposed to evaluate the retarding effect of grain boundary on microcrack propagation.Outside of the original cracked grain,Mode I crack propagation below the threshold ΔK_(σ-th) is responsible for the formation of fine granular area(FGA,a nano-grain layer).Based on the Numerous Cyclic Pressing(NCP) model,it is proposed that crack type should be another necessary condition for the formation of FGA.

Mesopause temperatures and relative densities at midlatitudes observed by the Mengcheng meteor radar

The atmospheric temperatures and densities in the mesosphere and lower thermosphere(MLT)region are essential for studying the dynamics and climate of the middle and upper atmosphere.In this study,we present more than 9 years of mesopause temperatures and relative densities estimated by using ambipolar diffusion coefficient measurements observed by the Mengcheng meteor radar(33.4°N,116.5°E).The intercomparison between the meteor radar and Thermosphere Ionosphere Mesosphere Energetics and Dynamics/Sounding of the Atmosphere by Broadband Emission Radiometry(TIMED/SABER)and Earth Observing System(EOS)Aura/Microwave Limb Sounder(MLS)observations indicates that the meteor radar temperatures and densities agree well with the simultaneous satellite measurements.Annual variations dominate the mesopause temperatures,with the maximum during winter and the minimum during summer.The mesopause relative densities also show annual variations,with strong maxima near the spring equinox and weak maxima before the winter solstice,and with a minimum during summer.In addition,the mesopause density exhibits a structure similar to that of the zonal wind:as the zonal wind flows eastward(westward),the mesopause density decreases(increases).At the same time,the meridional wind shows a structure similar to that of the mesopause temperature:as the meridional wind shows northward(southward)enhancements,the mesopause temperature increases(decreases).Simultaneous horizontal wind,temperature,and density observations provide multiple mesospheric parameters for investigating mesospheric dynamics and thermodynamic processes and have the potential to improve widely used empirical atmospheric models.

Numerical investigation on cooling performance of filter in a pyrotechnic gas generator

As a key part of the pyrotechnic gas generator,the filter not only removes the particulate matter but also cools the hot gas to a safe level.This paper aims to improve the understanding of the basic heat and flow phenomenon in the gas generator.The pyrotechnic gas generator is modelling by a simplified filter structure with fiber arrays.A finite-volume model of the heat and fluid flow is proposed to simulate the detailed multi-dimensional flow and energy conversion behaviors.Several verification results are in good agreement with data in different references.Simulation results demonstrate that the filter can not only absorb heat from the gas but also cause the high intensity enhancement of the heat transfer.The performance difference between inline and staggered arrays is also discussed.The findings of the study put a further prediction tool for the understanding and design of the filter system with fibers.