Anti-programmed cell death-1(anti-PD-1)therapies have shown a favorable efficacy and good tolerance for relapsed or refractory(r/r)classical Hodgkin lymphoma(cHL).However,there are limited data on long-term outcomes a...Anti-programmed cell death-1(anti-PD-1)therapies have shown a favorable efficacy and good tolerance for relapsed or refractory(r/r)classical Hodgkin lymphoma(cHL).However,there are limited data on long-term outcomes among patients with r/r cHL who achieve an objective response to anti-PD-1 therapies.A total of 260 responders from four,phase 2 clinical trials were included in this study.The median age was 32 years with a male/female ratio of 1.3:1.After a median follow-up period of 31.1 months,116(44.6%)responders experienced disease progression and 18(6.9%)died.展开更多
Given the harsh reality faced by the global effort to contain coronavirus disease 2019(COVID-19)and the virtual impossibility of its worldwide eradication in the foreseeable future,global human coexistence with fast m...Given the harsh reality faced by the global effort to contain coronavirus disease 2019(COVID-19)and the virtual impossibility of its worldwide eradication in the foreseeable future,global human coexistence with fast mutating severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)may have to occur,for the time being,irrespective of the wishes and aspirations of our people.Therefore,for China,the risk associated with small to medium scale outbreaks induced by imported cases and the corresponding need to continuously and promptly suppress domestic infections would persist for a certain period of time.展开更多
Background On December 31,2019,the World Health Organization(WHO)was alerted to several cases of pneumonia of unknown etiology in Wuhan,the capital city of Hubei Province in Central China.A novel coronavirus(2019-nCoV...Background On December 31,2019,the World Health Organization(WHO)was alerted to several cases of pneumonia of unknown etiology in Wuhan,the capital city of Hubei Province in Central China.A novel coronavirus(2019-nCoV)was identified as the causative virus by Chinese authorities on January 7,2020(1),and China CDC has named the associated disease as novel coronavirus-infected pneumonia(NCIP)(2–3).As of January 23,2020,the National Health Commission(NHC)of China had confirmed a total of 830 cases of NCIP in China's Mainland,including 177 in critical condition,25 fatalities,and 34 recoveries.In Wuhan the origin of the NCIP outbreak,495 cases including 24 fatalities have been confirmed.In addition to the cases in China's Mainland,two cases have been detected in Hong Kong Special Administrative Region,China,two in Macao Special Administrative Region,China,one in Taiwan.展开更多
Introduction:The coronavirus disease 2019(COVID-19)pandemic has been going on for over a year and has reemerged in several regions.Therefore,understanding the covertness of COVID-19 is critical to more precisely estim...Introduction:The coronavirus disease 2019(COVID-19)pandemic has been going on for over a year and has reemerged in several regions.Therefore,understanding the covertness of COVID-19 is critical to more precisely estimating the pandemic size,especially the population of hidden carriers(those with very mild or no symptoms).Methods:A stochastic dynamic model was proposed to capture the transmission mechanism of COVID-19 and to depict the covertness of COVID-19.The proposed model captured unique features of COVID-19,changes in the diagnosis criteria,and escalating containment measures.Results:The model estimated that,for the epidemic in Wuhan,79.8%(76.7%-82.7%)of the spread was caused by hidden carriers.The overall lab-confirmation rate in Wuhan up until March 8,2020 was 0.17(0.15-0.19).The diagnostic rate among patients with significant symptoms went up to 0.82 on March 8,2020 from 0.43 on January 1,2020 with escalating containment measures and nationwide medical supports.The probability of resurgence could be as high as 0.72 if containment measures were lifted after zero new reported(lab-confirmed or clinically confirmed)cases in a consecutive period of 14 days.This probability went down to 0.18 and 0.01 for measures lifted after 30 and 60 days,respectively.Discussion:Consistent with the cases detected in Wuhan in mid-May,2020,this study suggests that much of the COVID-19 pandemic is underreported and highly covert,which suggests that strict measures must be enforced continuously to contain the spread of the pandemic.展开更多
基金This study was supported by the Clinical Research Fund for Distinguished Young Scholars of Beijing Cancer Hospital(Grant No.QNJJ202106)Beijing Xisike Clinical Oncology Research Foundation(Grant No.Y-HS202202-0104 and Y-Young2023-0286)National Natural Science Foundation of China(Grant No.81972807).
文摘Anti-programmed cell death-1(anti-PD-1)therapies have shown a favorable efficacy and good tolerance for relapsed or refractory(r/r)classical Hodgkin lymphoma(cHL).However,there are limited data on long-term outcomes among patients with r/r cHL who achieve an objective response to anti-PD-1 therapies.A total of 260 responders from four,phase 2 clinical trials were included in this study.The median age was 32 years with a male/female ratio of 1.3:1.After a median follow-up period of 31.1 months,116(44.6%)responders experienced disease progression and 18(6.9%)died.
基金National Natural Science Foundation of China grant 8204100362The Bill&Melinda Gates Foundation(INV-016826).
文摘Given the harsh reality faced by the global effort to contain coronavirus disease 2019(COVID-19)and the virtual impossibility of its worldwide eradication in the foreseeable future,global human coexistence with fast mutating severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)may have to occur,for the time being,irrespective of the wishes and aspirations of our people.Therefore,for China,the risk associated with small to medium scale outbreaks induced by imported cases and the corresponding need to continuously and promptly suppress domestic infections would persist for a certain period of time.
文摘Background On December 31,2019,the World Health Organization(WHO)was alerted to several cases of pneumonia of unknown etiology in Wuhan,the capital city of Hubei Province in Central China.A novel coronavirus(2019-nCoV)was identified as the causative virus by Chinese authorities on January 7,2020(1),and China CDC has named the associated disease as novel coronavirus-infected pneumonia(NCIP)(2–3).As of January 23,2020,the National Health Commission(NHC)of China had confirmed a total of 830 cases of NCIP in China's Mainland,including 177 in critical condition,25 fatalities,and 34 recoveries.In Wuhan the origin of the NCIP outbreak,495 cases including 24 fatalities have been confirmed.In addition to the cases in China's Mainland,two cases have been detected in Hong Kong Special Administrative Region,China,two in Macao Special Administrative Region,China,one in Taiwan.
基金National Natural Science Foundation of China grant 8204100362The Bill&Melinda Gates Foundation(INV-016826).
文摘Introduction:The coronavirus disease 2019(COVID-19)pandemic has been going on for over a year and has reemerged in several regions.Therefore,understanding the covertness of COVID-19 is critical to more precisely estimating the pandemic size,especially the population of hidden carriers(those with very mild or no symptoms).Methods:A stochastic dynamic model was proposed to capture the transmission mechanism of COVID-19 and to depict the covertness of COVID-19.The proposed model captured unique features of COVID-19,changes in the diagnosis criteria,and escalating containment measures.Results:The model estimated that,for the epidemic in Wuhan,79.8%(76.7%-82.7%)of the spread was caused by hidden carriers.The overall lab-confirmation rate in Wuhan up until March 8,2020 was 0.17(0.15-0.19).The diagnostic rate among patients with significant symptoms went up to 0.82 on March 8,2020 from 0.43 on January 1,2020 with escalating containment measures and nationwide medical supports.The probability of resurgence could be as high as 0.72 if containment measures were lifted after zero new reported(lab-confirmed or clinically confirmed)cases in a consecutive period of 14 days.This probability went down to 0.18 and 0.01 for measures lifted after 30 and 60 days,respectively.Discussion:Consistent with the cases detected in Wuhan in mid-May,2020,this study suggests that much of the COVID-19 pandemic is underreported and highly covert,which suggests that strict measures must be enforced continuously to contain the spread of the pandemic.
