Summary:Choosing proper perfusates as contrast agents is an important aspect for postmortem magnetic resonance angiography(PMMRA).However,in this emerging field,the number of suitable kinds of liquid is still very lim...Summary:Choosing proper perfusates as contrast agents is an important aspect for postmortem magnetic resonance angiography(PMMRA).However,in this emerging field,the number of suitable kinds of liquid is still very limited.The objective of this research is to compare MR images of oleic acid(OA)with paraffin oil(PO)in vitro and in ex situ animal hearts,in order to evaluate the feasibility to use OA as a novel contrast agent for PMMRA.In vitro,OA,PO and water(control)were introduced into three tubes separately and T,weighted-spin echo(Tw SE)and T2w-SE images were acquired on a 1.5T MR scanner.In the second experiment,0A and PO were injected into left coronary artery(LCA)and left ventricle(LV)of ex situ bovine hearts and their Tw-SE,Tzw-SE,Tw-multipoint Dixon(Tjw-mDixon)and 3DT2w-mDixon images were acquired.The overall results indicate that OA may have a potential to be used as a dual(T and T2 based)contrast agent for PMMRA when proper sequence parameters are utilized.However,as the pilot study was based on limited number of animal hearts,more researches using OA in cadavers are needed to validate our findings.展开更多
For the medicolegal evaluation of victims of survived strangulation,a neck-magnetic resonance imaging(MRI)can be performed for assessing lesions in the inner soft tissues(fat,muscles or lymph nodes,for example).In our...For the medicolegal evaluation of victims of survived strangulation,a neck-magnetic resonance imaging(MRI)can be performed for assessing lesions in the inner soft tissues(fat,muscles or lymph nodes,for example).In our institute,such MRI examinations have been performed for a test period of 4 years with the aim of evaluating the use of this tool by forensic pathologists and identifying medicolegal indicators for the performance of neck-MRI in surviving victims of strangulation.We retrospectively reviewed medicolegal reports from all victims examined during the test period.We extracted objective lesions(e.g.petechiae,bruising and abrasions)and reported clinical symptoms(e.g.vision disorder,dysphasia)from the reports.These findings were compared to those reported from the neck-MRI.In total,112 victims were clinically examined after suspected strangulation.Eleven of these victims underwent an MRI examination of the neck.Eighty-four of the victims presented objective lesions during the clinical examination,with eight showing signs of both petechiae and bruising.Neck-MRI was performed in four of these eight victims and three of them showed lesions visible in MRI.Of 76 victims with bruising as the only objective finding,66 victims described clinical symptoms.Of those 66 victims,seven were examined by MRI and two demonstrated lesions in MRI.When MRI was performed,relevant findings were detected in 45%of the cases.This leads to the suspicion that many more findings could have been detected in the other victims,if an MRI had been performed in those cases.Our results lead us to the conclusion that an MRI examination of victims of suspected strangulation is useful,and strict indications for its application should be established.展开更多
基金This project was supported by a grant from China Scholarship Council(No.CSC 201707070113).
文摘Summary:Choosing proper perfusates as contrast agents is an important aspect for postmortem magnetic resonance angiography(PMMRA).However,in this emerging field,the number of suitable kinds of liquid is still very limited.The objective of this research is to compare MR images of oleic acid(OA)with paraffin oil(PO)in vitro and in ex situ animal hearts,in order to evaluate the feasibility to use OA as a novel contrast agent for PMMRA.In vitro,OA,PO and water(control)were introduced into three tubes separately and T,weighted-spin echo(Tw SE)and T2w-SE images were acquired on a 1.5T MR scanner.In the second experiment,0A and PO were injected into left coronary artery(LCA)and left ventricle(LV)of ex situ bovine hearts and their Tw-SE,Tzw-SE,Tw-multipoint Dixon(Tjw-mDixon)and 3DT2w-mDixon images were acquired.The overall results indicate that OA may have a potential to be used as a dual(T and T2 based)contrast agent for PMMRA when proper sequence parameters are utilized.However,as the pilot study was based on limited number of animal hearts,more researches using OA in cadavers are needed to validate our findings.
文摘For the medicolegal evaluation of victims of survived strangulation,a neck-magnetic resonance imaging(MRI)can be performed for assessing lesions in the inner soft tissues(fat,muscles or lymph nodes,for example).In our institute,such MRI examinations have been performed for a test period of 4 years with the aim of evaluating the use of this tool by forensic pathologists and identifying medicolegal indicators for the performance of neck-MRI in surviving victims of strangulation.We retrospectively reviewed medicolegal reports from all victims examined during the test period.We extracted objective lesions(e.g.petechiae,bruising and abrasions)and reported clinical symptoms(e.g.vision disorder,dysphasia)from the reports.These findings were compared to those reported from the neck-MRI.In total,112 victims were clinically examined after suspected strangulation.Eleven of these victims underwent an MRI examination of the neck.Eighty-four of the victims presented objective lesions during the clinical examination,with eight showing signs of both petechiae and bruising.Neck-MRI was performed in four of these eight victims and three of them showed lesions visible in MRI.Of 76 victims with bruising as the only objective finding,66 victims described clinical symptoms.Of those 66 victims,seven were examined by MRI and two demonstrated lesions in MRI.When MRI was performed,relevant findings were detected in 45%of the cases.This leads to the suspicion that many more findings could have been detected in the other victims,if an MRI had been performed in those cases.Our results lead us to the conclusion that an MRI examination of victims of suspected strangulation is useful,and strict indications for its application should be established.
