Objective: The current study aimed to investigate whether the level of consciousness influenced the F wave generation, as an independent factor. Methods: Forty three patients with acute stroke were divided according t...Objective: The current study aimed to investigate whether the level of consciousness influenced the F wave generation, as an independent factor. Methods: Forty three patients with acute stroke were divided according to their level of consciousness in two groups; to those with Glasgow scale (GCS) score 3-7 indicating coma (group I) and those with GCS score 8-15 (group II). A series of 40 electrical stimuli were delivered to the ulnar nerve bilaterally in order to obtain F waves. The following variables were estimated and then compared between groups: F persistence, F wave latency, amplitude and duration. All studies were performed within 3 days from the onset of the stroke symptoms. Results: The main finding to emerge was the significantly reduced F wave persistence in the group of patients with low GCS score as opposed to patients allocated in the group with GCS score 8-15. This result is referred to F waves obtained from both the affected and unaffected limb. F wave minimum latency w as also prolonged in the group with low GCS score, whilst the comparison of all other F wave variables revealed no significant differences between groups I and II. F wave persistence measurements did not differ between the affected and unaffected sides. Stroke location and type (ischemic or hemorrhagic) were not associated with alterations of F wave measurements. Conclusions: Our results on stroke patients suggest that generation of F waves, expressed by the F wave persistence is associated with the level of consciousness. Significance: F wave study may be useful as an objective measure in documenting the severity of consciousness impairment.展开更多
We present here the course of clinical response of a 53-yearold haemodialysed Fabry patient who received recombinant human α-galactosidase A at a dose of 1 mg/kg every other week over a period of 1 year. The therapy ...We present here the course of clinical response of a 53-yearold haemodialysed Fabry patient who received recombinant human α-galactosidase A at a dose of 1 mg/kg every other week over a period of 1 year. The therapy was well tolerated by the patient, who revealed an impressive favourable cutaneous, gastrointestina l, neurological and psychiatric response and a dramatic improvement in his quali ty of life,but no improvement in cardiac and renal function.展开更多
文摘Objective: The current study aimed to investigate whether the level of consciousness influenced the F wave generation, as an independent factor. Methods: Forty three patients with acute stroke were divided according to their level of consciousness in two groups; to those with Glasgow scale (GCS) score 3-7 indicating coma (group I) and those with GCS score 8-15 (group II). A series of 40 electrical stimuli were delivered to the ulnar nerve bilaterally in order to obtain F waves. The following variables were estimated and then compared between groups: F persistence, F wave latency, amplitude and duration. All studies were performed within 3 days from the onset of the stroke symptoms. Results: The main finding to emerge was the significantly reduced F wave persistence in the group of patients with low GCS score as opposed to patients allocated in the group with GCS score 8-15. This result is referred to F waves obtained from both the affected and unaffected limb. F wave minimum latency w as also prolonged in the group with low GCS score, whilst the comparison of all other F wave variables revealed no significant differences between groups I and II. F wave persistence measurements did not differ between the affected and unaffected sides. Stroke location and type (ischemic or hemorrhagic) were not associated with alterations of F wave measurements. Conclusions: Our results on stroke patients suggest that generation of F waves, expressed by the F wave persistence is associated with the level of consciousness. Significance: F wave study may be useful as an objective measure in documenting the severity of consciousness impairment.
文摘We present here the course of clinical response of a 53-yearold haemodialysed Fabry patient who received recombinant human α-galactosidase A at a dose of 1 mg/kg every other week over a period of 1 year. The therapy was well tolerated by the patient, who revealed an impressive favourable cutaneous, gastrointestina l, neurological and psychiatric response and a dramatic improvement in his quali ty of life,but no improvement in cardiac and renal function.
