To the Editor:Renal cell carcinoma(RCC)accounts for approximately 3%of all malignancies in adults.[1]Locally advanced RCC has a relatively distinct and adverse prognosis with a 5-year cancer specific survival(CSS)rate...To the Editor:Renal cell carcinoma(RCC)accounts for approximately 3%of all malignancies in adults.[1]Locally advanced RCC has a relatively distinct and adverse prognosis with a 5-year cancer specific survival(CSS)rate ranging from 28%to 67%after curative surgery.[2]It is important to accurately stratify the risk of disease recurrence for locally advanced RCC.Several prognostic models like Stage,Size,Grade,and Necrosis(SSIGN),Leibovich,Cindolo,Yaycioglu,Memorial Sloan Kettering Cancer Center(MSKCC),Kattan,and Karakiewicz have been developed to predict the prognosis of localized RCC and the concordance index(C-index)has been found to range from 0.65 to 0.84.[3,4]To our knowledge,these models have mainly been developed based on the data from low-risk patients with RCC.In an external prospec-tive cohort comprising patients with intermediate or high-risk RCC,the performances of these models were found to be sharply decreased(C-index range from 0.587 to 0.69).[4]Thus,in this study,we aimed to develop a more accurate prognostic model for better risk stratification in locally advanced RCC.展开更多
文摘To the Editor:Renal cell carcinoma(RCC)accounts for approximately 3%of all malignancies in adults.[1]Locally advanced RCC has a relatively distinct and adverse prognosis with a 5-year cancer specific survival(CSS)rate ranging from 28%to 67%after curative surgery.[2]It is important to accurately stratify the risk of disease recurrence for locally advanced RCC.Several prognostic models like Stage,Size,Grade,and Necrosis(SSIGN),Leibovich,Cindolo,Yaycioglu,Memorial Sloan Kettering Cancer Center(MSKCC),Kattan,and Karakiewicz have been developed to predict the prognosis of localized RCC and the concordance index(C-index)has been found to range from 0.65 to 0.84.[3,4]To our knowledge,these models have mainly been developed based on the data from low-risk patients with RCC.In an external prospec-tive cohort comprising patients with intermediate or high-risk RCC,the performances of these models were found to be sharply decreased(C-index range from 0.587 to 0.69).[4]Thus,in this study,we aimed to develop a more accurate prognostic model for better risk stratification in locally advanced RCC.
