AIM: To study morphologic and biomechanical changes of oesophagus in diabetes rats.METHODS: Diabetes was induced by a single injection of streptozotocin (STZ). The type of diabetes mellitus induced by parenteral STZ a...AIM: To study morphologic and biomechanical changes of oesophagus in diabetes rats.METHODS: Diabetes was induced by a single injection of streptozotocin (STZ). The type of diabetes mellitus induced by parenteral STZ administration in rats was insulin-dependent (type I). The samples were excised and studied in vitro using a self-developed biomaterial test machine.RESULTS: The body mass was decreased after 4 d with STZ treatment. The length of esophagus shortened after 4, 7,14 d. The opening angle increased after 14 d. The shear,longitudinal and circumferential stiffness were obviously raised after 28 d of STZ treatment.CONCLUSION: The changes of passive biomechanical properties reflect intra-structural alteration of tissue to a certain extent. This alteration will lead to some dysfunction of movement. For example, tension of esophageal wall will change due to some obstructive disease.展开更多
文摘AIM: To study morphologic and biomechanical changes of oesophagus in diabetes rats.METHODS: Diabetes was induced by a single injection of streptozotocin (STZ). The type of diabetes mellitus induced by parenteral STZ administration in rats was insulin-dependent (type I). The samples were excised and studied in vitro using a self-developed biomaterial test machine.RESULTS: The body mass was decreased after 4 d with STZ treatment. The length of esophagus shortened after 4, 7,14 d. The opening angle increased after 14 d. The shear,longitudinal and circumferential stiffness were obviously raised after 28 d of STZ treatment.CONCLUSION: The changes of passive biomechanical properties reflect intra-structural alteration of tissue to a certain extent. This alteration will lead to some dysfunction of movement. For example, tension of esophageal wall will change due to some obstructive disease.
