To achieve head-to-tail cyclic peptides via the liquid-phase on-support cyclization and synergistic self-cleavage strategy,4,4’-bis(diphenylphosphinyloxyl)diphenyl ketoxime(BDKO)and 4-diphenyl phospho-loxy benzyl alc...To achieve head-to-tail cyclic peptides via the liquid-phase on-support cyclization and synergistic self-cleavage strategy,4,4’-bis(diphenylphosphinyloxyl)diphenyl ketoxime(BDKO)and 4-diphenyl phospho-loxy benzyl alcohol(DPBA)were designed and prepared as small-molecular supports of greener peptide synthesis.In the process of the BDKO(or DPBA)support assisted Boc strategy for liquid-phase peptide chain extension,the last amino acid at the N-terminus of the peptide chain ends with a Fmoc protected amino acid.展开更多
基金This work was supported by the National Natural Science Foundation of China(21572180)the Intergovernmental Science and Technology Cooperation and Exchange Program between China and Romania(43-24-20180510)the National College Students’Innovation and Entrepreneurship Training Program of China(S201910699286).
文摘To achieve head-to-tail cyclic peptides via the liquid-phase on-support cyclization and synergistic self-cleavage strategy,4,4’-bis(diphenylphosphinyloxyl)diphenyl ketoxime(BDKO)and 4-diphenyl phospho-loxy benzyl alcohol(DPBA)were designed and prepared as small-molecular supports of greener peptide synthesis.In the process of the BDKO(or DPBA)support assisted Boc strategy for liquid-phase peptide chain extension,the last amino acid at the N-terminus of the peptide chain ends with a Fmoc protected amino acid.
