The set-net fi shery resources in Haizhou Bay,China have been over-exploited because of over-fi shing and environmental deterioration.To better understand the current situations and the development trends of fi shery ...The set-net fi shery resources in Haizhou Bay,China have been over-exploited because of over-fi shing and environmental deterioration.To better understand the current situations and the development trends of fi shery resources,the temporal change of biological characteristics and community compositions were analyzed from 2011 to 2018.Meanwhile,we evaluated the impact of the summer moratorium of marine fi shing(SMMF)on the set-net fi shery.Results show that the mean total length of the six principal species showed varying degrees of decreasing trends,while the changing patterns for the mean weight proportion of the six groups varied.For the whole communities,the similarities of the inter-annual community diversities and compositions were high.SMMF is meaningful to help reproductive success and support recruitment.Every year,the catch per unit eff orts of the six principal species after SMMF were signifi cantly higher than before SMMF except for Octopus ocellatus.The target groups showed a higher mean weight proportion after SMMF than before SMMF in eight years,while the non-target groups were converse.Therefore,the resources of the set-net fi shery are changing in the study periods;and SMMF is an important factor infl uencing biological characteristics and community structure.Despite some challenges,SMMF is still one of the most appropriate policy tools to protect the set-net fi shery resources under the reality of China.展开更多
Background:Ciprofol(HSK3486;Haisco Pharmaceutical Group Co.,Ltd.,Chengdu,China),developed as a novel 2,6-disubstituted phenol derivative showed similar tolerability and efficacy characteristics as propofol when applic...Background:Ciprofol(HSK3486;Haisco Pharmaceutical Group Co.,Ltd.,Chengdu,China),developed as a novel 2,6-disubstituted phenol derivative showed similar tolerability and efficacy characteristics as propofol when applicated as continuous intravenous infusion for 12 h maintenance sedation in a previous phase 1 trial.The phase 2 trial was designed to investigate the safety,efficacy,and pharmacokinetic characteristics of ciprofol for sedation of patients undergoing mechanical ventilation.Methods:In this multicenter,open label,randomized,propofol positive-controlled,phase 2 trial,39 Chinese intensive care unit patients receiving mechanical ventilation were enrolled and randomly assigned to a ciprofol or propofol group in a 2:1 ratio.The ciprofol infusion was started with a loading infusion of 0.1-0.2 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 0.30 mg·kg^(-1)·h^(-1),which could be adjusted to an infusion rate of 0.06 to 0.80 mg·kg^(-1)·h^(-1),whereas for propofol the loading infusion dose was 0.5-1.0 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 1.50 mg·kg^(-1)·h^(-1),which could be adjusted to 0.30-4.00 mg·kg^(-1)·h^(-1)to achieve-2 to+1 Richmond Agitation-Sedation Scale sedation within 6-24 h of drug administration.Results:Of the 39 enrolled patients,36 completed the trial.The median(min,max)of the average time to sedation compliance values for ciprofol and propofol were 60.0(52.6,60.0)min and 60.0(55.2,60.0)min,with median difference of 0.00(95%confidence interval:0.00,0.00).In total,29(74.4%)patients comprising 18(69.2%)in the ciprofol and 11(84.6%)in the propofol group experienced 86 treatment emergent adverse events(TEAEs),the majority being of severity grade 1 or 2.Drug-and sedation-related TEAEs were hypotension(7.7%vs.23.1%,P=0.310)and sinus bradycardia(3.8%vs.7.7%,P=1.000)in the ciprofol and propofol groups,respectively.The plasma concentration-time curves for ciprofol and propofol were similar.Conclusions:ciprofol is comparable to propofol with good tolerance and efficacy for sedation of Chinese intensive care unit patients undergoing mechanical ventilation in the present study setting.Trial registration:ClinicalTrials.gov,NCT04147416.展开更多
To increase the service life of rechargeable batteries,transition metal oxide hosts with high structural stability for the intercalation of carrier ions are important.Herein,we reconstruct the crystal structure of a c...To increase the service life of rechargeable batteries,transition metal oxide hosts with high structural stability for the intercalation of carrier ions are important.Herein,we reconstruct the crystal structure of a commercial V_(2)O_(5)by pre-intercalating H^(+)and H_(2)O pillars using a facile hydrothermal reaction and obtain a bi-layer structured H_(0.642)V_(2)O_(5)·0.143H_(2)O(HVO)as an excellent host for aqueous Zn-ion batteries.Benefiting from the structural reconstruction,the irreversible“layer-to-amorphous”phase evolution during cycling is considerably less,resulting in ultra-high cycling stability of HVO with nearly no capacity fading even after 500 cycles at a current density of 0.5Ag^(-1).Moreover,a synthetic proton and Zn^(2+)intercalation mechanism in the HVO host is demonstrated.This work provides both a facile synthesis method for the preparation of V-based compounds and a new viewpoint for achieving high-performance host materials.展开更多
基金Supported by the Argo-Scientifi c Research in the Public Interest,China(No.201203018)。
文摘The set-net fi shery resources in Haizhou Bay,China have been over-exploited because of over-fi shing and environmental deterioration.To better understand the current situations and the development trends of fi shery resources,the temporal change of biological characteristics and community compositions were analyzed from 2011 to 2018.Meanwhile,we evaluated the impact of the summer moratorium of marine fi shing(SMMF)on the set-net fi shery.Results show that the mean total length of the six principal species showed varying degrees of decreasing trends,while the changing patterns for the mean weight proportion of the six groups varied.For the whole communities,the similarities of the inter-annual community diversities and compositions were high.SMMF is meaningful to help reproductive success and support recruitment.Every year,the catch per unit eff orts of the six principal species after SMMF were signifi cantly higher than before SMMF except for Octopus ocellatus.The target groups showed a higher mean weight proportion after SMMF than before SMMF in eight years,while the non-target groups were converse.Therefore,the resources of the set-net fi shery are changing in the study periods;and SMMF is an important factor infl uencing biological characteristics and community structure.Despite some challenges,SMMF is still one of the most appropriate policy tools to protect the set-net fi shery resources under the reality of China.
文摘Background:Ciprofol(HSK3486;Haisco Pharmaceutical Group Co.,Ltd.,Chengdu,China),developed as a novel 2,6-disubstituted phenol derivative showed similar tolerability and efficacy characteristics as propofol when applicated as continuous intravenous infusion for 12 h maintenance sedation in a previous phase 1 trial.The phase 2 trial was designed to investigate the safety,efficacy,and pharmacokinetic characteristics of ciprofol for sedation of patients undergoing mechanical ventilation.Methods:In this multicenter,open label,randomized,propofol positive-controlled,phase 2 trial,39 Chinese intensive care unit patients receiving mechanical ventilation were enrolled and randomly assigned to a ciprofol or propofol group in a 2:1 ratio.The ciprofol infusion was started with a loading infusion of 0.1-0.2 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 0.30 mg·kg^(-1)·h^(-1),which could be adjusted to an infusion rate of 0.06 to 0.80 mg·kg^(-1)·h^(-1),whereas for propofol the loading infusion dose was 0.5-1.0 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 1.50 mg·kg^(-1)·h^(-1),which could be adjusted to 0.30-4.00 mg·kg^(-1)·h^(-1)to achieve-2 to+1 Richmond Agitation-Sedation Scale sedation within 6-24 h of drug administration.Results:Of the 39 enrolled patients,36 completed the trial.The median(min,max)of the average time to sedation compliance values for ciprofol and propofol were 60.0(52.6,60.0)min and 60.0(55.2,60.0)min,with median difference of 0.00(95%confidence interval:0.00,0.00).In total,29(74.4%)patients comprising 18(69.2%)in the ciprofol and 11(84.6%)in the propofol group experienced 86 treatment emergent adverse events(TEAEs),the majority being of severity grade 1 or 2.Drug-and sedation-related TEAEs were hypotension(7.7%vs.23.1%,P=0.310)and sinus bradycardia(3.8%vs.7.7%,P=1.000)in the ciprofol and propofol groups,respectively.The plasma concentration-time curves for ciprofol and propofol were similar.Conclusions:ciprofol is comparable to propofol with good tolerance and efficacy for sedation of Chinese intensive care unit patients undergoing mechanical ventilation in the present study setting.Trial registration:ClinicalTrials.gov,NCT04147416.
基金supported by the Basic and Applied Basic Research Foundation of Guangdong Province(2019A1515110094).
文摘To increase the service life of rechargeable batteries,transition metal oxide hosts with high structural stability for the intercalation of carrier ions are important.Herein,we reconstruct the crystal structure of a commercial V_(2)O_(5)by pre-intercalating H^(+)and H_(2)O pillars using a facile hydrothermal reaction and obtain a bi-layer structured H_(0.642)V_(2)O_(5)·0.143H_(2)O(HVO)as an excellent host for aqueous Zn-ion batteries.Benefiting from the structural reconstruction,the irreversible“layer-to-amorphous”phase evolution during cycling is considerably less,resulting in ultra-high cycling stability of HVO with nearly no capacity fading even after 500 cycles at a current density of 0.5Ag^(-1).Moreover,a synthetic proton and Zn^(2+)intercalation mechanism in the HVO host is demonstrated.This work provides both a facile synthesis method for the preparation of V-based compounds and a new viewpoint for achieving high-performance host materials.
