We have developed a metal-free radical cascade reaction of N-substituted 2-aryl indoles with readily available sulfonyl hydrazides for the rapid construction of arylsulfonyl-substituted indolo[2,1-a]isoquinolin-6(5H)-...We have developed a metal-free radical cascade reaction of N-substituted 2-aryl indoles with readily available sulfonyl hydrazides for the rapid construction of arylsulfonyl-substituted indolo[2,1-a]isoquinolin-6(5H)-one derivatives.With the TBAI–TBHP catalytic system,a broad series of structurally diverse indolo[2,1-a]isoquinolin-6(5H)-one derivatives were obtained in moderate to excellent yields.The reaction features mild reaction conditions,operationally easiness,scaled-up feasibility,and high functional-group-tolerance.展开更多
INTRODUCTION Organic single crystals have found wide-spread applications in smart materials,[1]optical waveguide devices,[2]photonic applications,[3]lasers,[4]OLED materials,and so on.
基金the State Key Basic Research Program of the People’s Republic of China (No. 2018YFC0310900)National Natural Science Foundation of China (Nos. 21871018, 21801005, 21732001)+7 种基金Shenzhen Science and Technology Innovation Committee (Nos. KQTD20190929174023858, JCYJ20180504165454447)Industry and Information Technology Bureau of Shenzhen Municipality (No. 201806151622209330)Guangdong Science and Technology Program (No. 2017B030314002)Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions (No. 2019SHIBS0004)the National Ten Thousand Talent Program (the Leading Talent Tier) for the financial supportthe Science and Technology Project of Henan Province (No. 202102310328)the Henan Postdoctoral Foundationthe Postdoctoral Innovation Base of Anyang Institute of Technology for financial support
文摘We have developed a metal-free radical cascade reaction of N-substituted 2-aryl indoles with readily available sulfonyl hydrazides for the rapid construction of arylsulfonyl-substituted indolo[2,1-a]isoquinolin-6(5H)-one derivatives.With the TBAI–TBHP catalytic system,a broad series of structurally diverse indolo[2,1-a]isoquinolin-6(5H)-one derivatives were obtained in moderate to excellent yields.The reaction features mild reaction conditions,operationally easiness,scaled-up feasibility,and high functional-group-tolerance.
基金Shanxi Province Science Foundation for Youth(20210302124468)Shanxi Province Natural Science Foundation(202303021211257).
文摘INTRODUCTION Organic single crystals have found wide-spread applications in smart materials,[1]optical waveguide devices,[2]photonic applications,[3]lasers,[4]OLED materials,and so on.
