To date, the coronavirus disease 2019 (COVID-19) outbreak has become a global pandemic and public health disaster. In addition to acute respiratory manifestations, patients with COVID-19 exhibit other non-respiratory ...To date, the coronavirus disease 2019 (COVID-19) outbreak has become a global pandemic and public health disaster. In addition to acute respiratory manifestations, patients with COVID-19 exhibit other non-respiratory manifestations, particularly in those with severe underlying disease. Few specific therapeutics are effective for COVID-19, and supportive care is the primary remedy. Here, we comprehensively surveyed the most recent reports on extrapulmonary complications of COVID-19 and their corresponding treatments, as well as the comparison of different clinical symptoms and complications of COVID-19, severe acute respiratory syndrome (SARS), and the Middle East respiratory syndrome (MERS) patients. We wish to provide a molecular and cellular understanding of the complications of COVID-19 and provide guidance for future diagnostics, therapeutics, and prognostics of COVID-19.展开更多
The metabolic engineering of Saccharomyces cerevisiae has great potential for enhancing the production of high-value chemicals and recombinant proteins.Recent studies have demonstrated the effectiveness of dynamic reg...The metabolic engineering of Saccharomyces cerevisiae has great potential for enhancing the production of high-value chemicals and recombinant proteins.Recent studies have demonstrated the effectiveness of dynamic regu-lation as a strategy for optimizing metabolic flux and improving production efficiency.In this review,we provide an overview of recent advancements in the dynamic regulation of S.cerevisiae metabolism.Here,we focused on the successful utilization of transcription factor(TF)-based biosensors within the dynamic regulatory network of S.cerevisiae.These biosensors are responsive to a wide range of endogenous and exogenous signals,including chemical inducers,light,temperature,cell density,intracellular metabolites,and stress.Additionally,we ex-plored the potential of omics tools for the discovery of novel responsive promoters and their roles in fine-tuning metabolic networks.We also provide an outlook on the development trends in this field.展开更多
文摘To date, the coronavirus disease 2019 (COVID-19) outbreak has become a global pandemic and public health disaster. In addition to acute respiratory manifestations, patients with COVID-19 exhibit other non-respiratory manifestations, particularly in those with severe underlying disease. Few specific therapeutics are effective for COVID-19, and supportive care is the primary remedy. Here, we comprehensively surveyed the most recent reports on extrapulmonary complications of COVID-19 and their corresponding treatments, as well as the comparison of different clinical symptoms and complications of COVID-19, severe acute respiratory syndrome (SARS), and the Middle East respiratory syndrome (MERS) patients. We wish to provide a molecular and cellular understanding of the complications of COVID-19 and provide guidance for future diagnostics, therapeutics, and prognostics of COVID-19.
基金supported by the National Key Research and Devel-opment Program of China(2021YFC2100500)Science and Technology Program of Guangzhou,China(202002030337)Fundamental Re-search Funds for the Central Universities(2022ZYGXZR102).
文摘The metabolic engineering of Saccharomyces cerevisiae has great potential for enhancing the production of high-value chemicals and recombinant proteins.Recent studies have demonstrated the effectiveness of dynamic regu-lation as a strategy for optimizing metabolic flux and improving production efficiency.In this review,we provide an overview of recent advancements in the dynamic regulation of S.cerevisiae metabolism.Here,we focused on the successful utilization of transcription factor(TF)-based biosensors within the dynamic regulatory network of S.cerevisiae.These biosensors are responsive to a wide range of endogenous and exogenous signals,including chemical inducers,light,temperature,cell density,intracellular metabolites,and stress.Additionally,we ex-plored the potential of omics tools for the discovery of novel responsive promoters and their roles in fine-tuning metabolic networks.We also provide an outlook on the development trends in this field.
