Confronted with the Coronavirus disease 2019(COVID-19)pandemic,China has become an asset in tackling the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)transmission and mutation,with several innovative pla...Confronted with the Coronavirus disease 2019(COVID-19)pandemic,China has become an asset in tackling the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)transmission and mutation,with several innovative platforms,which provides various technical means in this persisting combat.Derived from collaborated researches,vaccines based on the spike protein of SARS-CoV-2 or inactivated whole virus are a cornerstone of the public health response to COVID-19.Herein,we outline representative vaccines in multiple routes,while the merits and plights of the existing vaccine strategies are also summarized.Likewise,new technologies may provide more potent or broader immunity and will contribute to fight against hypermutated SARS-CoV-2 variants.All in all,with the ultimate aim of delivering robust and durable protection that is resilient to emerging infectious disease,alongside the traditional routes,the discovery of innovative approach to developing effective vaccines based on virus properties remains our top priority.展开更多
Aluminum(alum)adjuvant is the most extensively used protein subunit vaccine adjuvant,and its effectiveness and safety have been widely recognized.The surface charge of the antigen determines its electrostatic adsorpti...Aluminum(alum)adjuvant is the most extensively used protein subunit vaccine adjuvant,and its effectiveness and safety have been widely recognized.The surface charge of the antigen determines its electrostatic adsorption to alum adjuvant,which directly affects the immune efficacy of the protein vaccine.In our study,we precisely modified its surface charge by inserting charged amino acids into the flexible region of the SARS-CoV-2 receptorbinding domain(RBD),achieving electrostatic adsorption and a site-specific anchor between the immunogen and alum adjuvant.展开更多
Dear Editor,To date,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused more than 223 million confirmed cases of coronavirus disease 2019(COVID-19),including 4.6 million deaths(https://covid19.wh...Dear Editor,To date,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused more than 223 million confirmed cases of coronavirus disease 2019(COVID-19),including 4.6 million deaths(https://covid19.who.int/).Since 2020,several SARS-CoV-2 variants including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)with immune evasiveness have emerged and fast spread.In a global research effort,scientists proposed multiple effective vaccine strategies to respond to the ongoing COVID-19 pandemic.Most vaccines currently in use or in clinical development target the SARS-CoV-2 Spike(S)glycoprotein,a homotrimer decorates on the viral surface;within it,a distinct receptor-binding domain(RBD,residues 331–524)is responsible for mediating cell entry and interaction with host receptor angiotensin-converting enzyme 2(ACE2).展开更多
文摘Confronted with the Coronavirus disease 2019(COVID-19)pandemic,China has become an asset in tackling the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)transmission and mutation,with several innovative platforms,which provides various technical means in this persisting combat.Derived from collaborated researches,vaccines based on the spike protein of SARS-CoV-2 or inactivated whole virus are a cornerstone of the public health response to COVID-19.Herein,we outline representative vaccines in multiple routes,while the merits and plights of the existing vaccine strategies are also summarized.Likewise,new technologies may provide more potent or broader immunity and will contribute to fight against hypermutated SARS-CoV-2 variants.All in all,with the ultimate aim of delivering robust and durable protection that is resilient to emerging infectious disease,alongside the traditional routes,the discovery of innovative approach to developing effective vaccines based on virus properties remains our top priority.
基金partially funded by the Defense Industrial Technology Development Program JCKY2020802B001 and the National Natural Science Foundation of China 82041019.
文摘Aluminum(alum)adjuvant is the most extensively used protein subunit vaccine adjuvant,and its effectiveness and safety have been widely recognized.The surface charge of the antigen determines its electrostatic adsorption to alum adjuvant,which directly affects the immune efficacy of the protein vaccine.In our study,we precisely modified its surface charge by inserting charged amino acids into the flexible region of the SARS-CoV-2 receptorbinding domain(RBD),achieving electrostatic adsorption and a site-specific anchor between the immunogen and alum adjuvant.
基金ACKNOWLEDGEMENTS The work is supported by the grant from the National Key Research and Development Program of China(2020YFC0841400)the National Natural Science Foundation of China(31800770,82041019).
文摘Dear Editor,To date,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused more than 223 million confirmed cases of coronavirus disease 2019(COVID-19),including 4.6 million deaths(https://covid19.who.int/).Since 2020,several SARS-CoV-2 variants including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)with immune evasiveness have emerged and fast spread.In a global research effort,scientists proposed multiple effective vaccine strategies to respond to the ongoing COVID-19 pandemic.Most vaccines currently in use or in clinical development target the SARS-CoV-2 Spike(S)glycoprotein,a homotrimer decorates on the viral surface;within it,a distinct receptor-binding domain(RBD,residues 331–524)is responsible for mediating cell entry and interaction with host receptor angiotensin-converting enzyme 2(ACE2).
