OBJECTIVE： To systematically assess the clinical ef- fectiveness of traditional Chinese medicine （TCM） in the treatment of functional dyspepsia （FD） of liv- er-stomach disharmony syndrome by meta-analysis. METHOD...OBJECTIVE： To systematically assess the clinical ef- fectiveness of traditional Chinese medicine （TCM） in the treatment of functional dyspepsia （FD） of liv- er-stomach disharmony syndrome by meta-analysis. METHODS： Random controlled trials （RCTs） were retrieved from databases, including Pubmed, China national knowledge infrastructure, Wanfang Data, VlP Information, and the Cochrane Library. Trials were selected according to inclusion criteria. The ef- fects of traditional Chinese medicine （TCM） versus prokinetic agents in the treatment of functional dyspepsia （FD） of liver-stomach disharmony syn- drome were compared by meta-analysis. RevMan 5.0.24 was used for data analysis. The effective rate was assessed by odds ratios （ORs）, and 95% confi- dence intervals （C＇/s） were calculated. The cure rate was analyzed by the Peto OR. Simple statistica~ anal- ysis was chosen to assess the frequency of pre- scribed Chinese herbs in treating this syndrome.RESULTS： Thirteen trials were included, involving 1153 patients, and these were of poor methodolog- ical quality. Twelve studies mentioned the effective rate and cure rate. TCM therapy showed a better clinical effect rate compared with that with proki- netic agents [OR： 3.2, 95% CI （2.27, 4.51）]. The TCM group also had a better cure rate than that in the group of prokinetic agents [Peto OR： 2.26, 95% CI （1.61, 3.18）]. With regard to the frequency of Chi- nese herbs used in these 13 trials, Baishao （Radix Paeoniae）, Chaihu （Radix Bupleuri）, and Gancao （Ra- dix Glycyrrhizae） were mostly prescribed, followed by Xiangfu （Rhizoma Cyperi）, Zhishi （Fructus Auran- tii Immaturus）, Zhiqiao （Fructus Aurantii）, Foshou （Citrus medica var.sarcodactylis）, and Chenpi （Peri- carpium Citri Reticulatae）. No serious adverse ef- fects were reported. CONCLUSION： TCM therapy shows a superior effec- tive rate and cure rate compared with those in pro- kinetic agents in the treatment of FD of liver-stom- ach disharmony syndrome. However, further strict- ly designed RCTs are required because of the poor quality of included trials.展开更多
基金Supported by Shenyang Municipal Program for Science and Technology 2011(F11-155-9-00)
文摘OBJECTIVE： To systematically assess the clinical ef- fectiveness of traditional Chinese medicine （TCM） in the treatment of functional dyspepsia （FD） of liv- er-stomach disharmony syndrome by meta-analysis. METHODS： Random controlled trials （RCTs） were retrieved from databases, including Pubmed, China national knowledge infrastructure, Wanfang Data, VlP Information, and the Cochrane Library. Trials were selected according to inclusion criteria. The ef- fects of traditional Chinese medicine （TCM） versus prokinetic agents in the treatment of functional dyspepsia （FD） of liver-stomach disharmony syn- drome were compared by meta-analysis. RevMan 5.0.24 was used for data analysis. The effective rate was assessed by odds ratios （ORs）, and 95% confi- dence intervals （C＇/s） were calculated. The cure rate was analyzed by the Peto OR. Simple statistica~ anal- ysis was chosen to assess the frequency of pre- scribed Chinese herbs in treating this syndrome.RESULTS： Thirteen trials were included, involving 1153 patients, and these were of poor methodolog- ical quality. Twelve studies mentioned the effective rate and cure rate. TCM therapy showed a better clinical effect rate compared with that with proki- netic agents [OR： 3.2, 95% CI （2.27, 4.51）]. The TCM group also had a better cure rate than that in the group of prokinetic agents [Peto OR： 2.26, 95% CI （1.61, 3.18）]. With regard to the frequency of Chi- nese herbs used in these 13 trials, Baishao （Radix Paeoniae）, Chaihu （Radix Bupleuri）, and Gancao （Ra- dix Glycyrrhizae） were mostly prescribed, followed by Xiangfu （Rhizoma Cyperi）, Zhishi （Fructus Auran- tii Immaturus）, Zhiqiao （Fructus Aurantii）, Foshou （Citrus medica var.sarcodactylis）, and Chenpi （Peri- carpium Citri Reticulatae）. No serious adverse ef- fects were reported. CONCLUSION： TCM therapy shows a superior effec- tive rate and cure rate compared with those in pro- kinetic agents in the treatment of FD of liver-stom- ach disharmony syndrome. However, further strict- ly designed RCTs are required because of the poor quality of included trials.
