A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-Ⅱ Photo-Immunotherapy of Metastatic Tumor

Massive efforts have been concentrated on the advance of eminent near-infrared(NIR) photothermal materials(PTMs) in the NIR-Ⅱ window(1000–1700 nm), especially organic PTMs because of their intrinsic biological safety compared with inorganic PTMs. However, so far, only a few NIR-Ⅱresponsive organic PTMs was explored, and their photothermal conversion efficiencies(PCEs) still remain relatively low. Herein, donor–acceptor conjugated diradical polymers with open-shell characteristics are explored for synergistically photothermal immunotherapy of metastatic tumors in the NIR-Ⅱ window. By employing side-chain regulation, the conjugated diradical polymer TTB-2 with obvious NIR-Ⅱ absorption was developed, and its nanoparticles realize a record-breaking PCE of 87.7% upon NIR-Ⅱ light illustration. In vitro and in vivo experiments demonstrate that TTB-2 nanoparticles show good tumor photoablation with navigation of photoacoustic imaging in the NIR-Ⅱ window, without any side-effect. Moreover, by combining with PD-1 antibody,the pulmonary metastasis of breast cancer is high-effectively prevented by the efficient photo-immunity effect. Thus, this study explores superior PTMs for cancer metastasis theranostics in the NIR-Ⅱ window, offering a new horizon in developing radical-characteristic NIR-Ⅱ photothermal materials.

Fundamental Understanding and Optimization Strategies for Dual‑Ion Batteries:A Review

There has been increasing demand for high-energy density and longcycle life rechargeable batteries to satisfy the ever-growing requirements for nextgeneration energy storage systems.Among all available candidates,dual-ion batteries(DIBs)have drawn tremendous attention in the past few years from both academic and industrial battery communities because of their fascinating advantages of high working voltage,excellent safety,and environmental friendliness.However,the dynamic imbalance between the electrodes and the mismatch of traditional electrolyte systems remain elusive.To fully employ the advantages of DIBs,the overall optimization of anode materials,cathode materials,and compatible electrolyte systems is urgently needed.Here,we review the development history and the reaction mechanisms involved in DIBs.Afterward,the optimization strategies toward DIB materials and electrolytes are highlighted.In addition,their energy-related applications are also provided.Lastly,the research challenges and possible development directions of DIBs are outlined.