BACKGROUND The prognostic value of late gadolinium enhancement(LGE)derived from cardiovascular magnetic resonance(CMR)is well studied,and several new metrics of LGE have emerged.However,some controversies remain;there...BACKGROUND The prognostic value of late gadolinium enhancement(LGE)derived from cardiovascular magnetic resonance(CMR)is well studied,and several new metrics of LGE have emerged.However,some controversies remain;therefore,further discussion is needed,and more precise risk stratification should be explored.AIM To investigate the associations between the positivity,extent,location,and pattern of LGE and multiple outcomes in dilated cardiomyopathy(DCM).METHODS PubMed,Ovid MEDLINE,and Cochrane Library were searched for studies that investigated the prognostic value of LGE in patients with DCM.Pooled hazard ratios(HRs)and 95%confidence intervals were calculated to assess the role of LGE in the risk stratification of DCM.RESULTS Nineteen studies involving 7330 patients with DCM were included in this metaanalysis and covered a wide spectrum of DCM,with a mean left ventricular ejection fraction between 21%and 50%.The meta-analysis revealed that the presence of LGE was associated with an increased risk of multiple adverse outcomes(all-cause mortality,HR:2.14;arrhythmic events,HR:5.12;and composite endpoints,HR:2.38;all P<0.001).Furthermore,every 1%increment in the extent of LGE was associated with an increased risk of all-cause mortality.Analysis of a subgroup revealed that the prognostic value varied based on different location and pattern of LGE.Additionally,we found that LGE was a stronger predictor of arrhythmic events in patients with greater left ventricular ejection fraction.CONCLUSION LGE by CMR in patients with DCM exhibited a substantial value in predicting adverse outcomes,and the extent,location,and pattern of LGE could provide additional information for risk stratification.展开更多
AIM:To determine whether and how magnetic resonance imaging(MRI)-based total liver volume(TLV) and diffusion weighted imaging(DWI) could predict liver fibrosis.METHODS:Sixteen experimental mature mini-pigs(6 males,10 ...AIM:To determine whether and how magnetic resonance imaging(MRI)-based total liver volume(TLV) and diffusion weighted imaging(DWI) could predict liver fibrosis.METHODS:Sixteen experimental mature mini-pigs(6 males,10 females),weighing between 20.0 and 24.0 kg were prospectively used to model liver fibrosis induced by intraperitoneal injection of 40% CCl4 dissolved in fat emulsion twice a week for 16 wk,and by feeding 40% CCl4 mixed with maize flour twice daily for the subsequent 5 wk.All the survival animals underwent percutaneous liver biopsy and DWI using b = 300,500 and 800 s/mm2 followed by abdominal gadolinium-enhanced MRI at the 0,5th,9th,16th and 21st weekend after beginning of the modeling.TLV was obtained on enhanced MRI,and apparent diffusion coefficient(ADC) was obtained on DWI.Hepatic tissue specimens were stained with hematoxylin and Masson' s trichrome staining for staging liver fibrosis.Pathological specimens were scored using the human METAVIR classification system.Statistical analyses were performed to determine whether and how the TLV and ADC could be used to predict the stage of liver fibrosis.RESULTS:TLV increased from stage 0 to 2 and decreased from stage 3(r = 0.211;P < 0.001).There was a difference in TLV between stage 0-1 and 2-4(P = 0.03) whereas no difference between stage 0-2 and 3-4(P = 0.71).TLV could predict stage ≥ 2 [area under receiver operating characteristic curve(AUC) = 0.682].There was a decrease in ADC values with increasing stage of fibrosis for b = 300,500 and 800 s/mm2(r =-0.418,-0.535 and-0.622,respectively;all P < 0.001).Differences were found between stage 0-1 and 2-4 in ADC values for b = 300,500 and 800 s/mm2,and between stage 0-2 and 3-4 for b = 500 or 800 s/mm2(all P < 0.05).For predicting stage ≥ 2 and ≥ 3,AUC was 0.803 and 0.847 for b = 500 s/mm2,and 0.848 and 0.887 for b = 800 s/mm2,respectively.CONCLUSION:ADC for b = 500 or 800 s/mm2 could be better than TLV and ADC for b = 300 s/mm2 to pre-dict fibrosis stage ≥ 2 or ≥ 3.展开更多
The palladium nanoparticles/carbon nanofibers（Pd NPs/CNFs） catalyst was prepared by the electrospinning method, the hydrazine hydrate solution reduction in an ice bath environment, the high temperature carbonization...The palladium nanoparticles/carbon nanofibers（Pd NPs/CNFs） catalyst was prepared by the electrospinning method, the hydrazine hydrate solution reduction in an ice bath environment, the high temperature carbonization. The catalyst was characterized by X-ray diffraction（XRD）, fieldemission scanning electron microscope（FE-SEM）, and transmission electron microscopy（TEM）. The nanofibers are not cross-linked and arranged in order. The surface of Pd NPs/CNFs is smooth, and it can be observed that a large number of particles were loaded and well-dispersed in carbon fiber matrix, and the particle distribution is uniform. The activity center of catalyst is Pd^（0）. The Pd NPs/CNFs exhibited a high efficiency, good reusability and stability in the Suzuki and Heck reactions. It can be used for at least five consecutive runs without significant loss of its catalytic activity. The good recyclability of Pd NPs/CNFs provides a way to greatly reduce the cost of the catalyst.展开更多
In this work, magnesium tetraphenylporphyrin （MgTPP） was used as a new supramolecular amine-fixing agent. Once introduced, C02 easily competes with MgTPP for amines, leading to the release of MgTPP. The processes ca...In this work, magnesium tetraphenylporphyrin （MgTPP） was used as a new supramolecular amine-fixing agent. Once introduced, C02 easily competes with MgTPP for amines, leading to the release of MgTPP. The processes can be explained by the fact that the association constant （Kassoc） values of MgTPP with amines were in the range of 0.6 （ethanolamine） to 3.9 （ethylenediamine）, which are lower than the Kassoc values of C02 with these amines. MgTPP interacted with aniline, ethanolamine, pyrrolidine, or ethylenediamine to form 1：1 adducts. Ethylenediamine presents a stronger Kassoc value for MgTPP, so it was considered an optimal agent for C02 capture.展开更多
基金the Research Grant of the National Natural Science Foundation of China,No.81801674Sichuan Province Science and Technology Support Program,No.2021YJ0242.
文摘BACKGROUND The prognostic value of late gadolinium enhancement(LGE)derived from cardiovascular magnetic resonance(CMR)is well studied,and several new metrics of LGE have emerged.However,some controversies remain;therefore,further discussion is needed,and more precise risk stratification should be explored.AIM To investigate the associations between the positivity,extent,location,and pattern of LGE and multiple outcomes in dilated cardiomyopathy(DCM).METHODS PubMed,Ovid MEDLINE,and Cochrane Library were searched for studies that investigated the prognostic value of LGE in patients with DCM.Pooled hazard ratios(HRs)and 95%confidence intervals were calculated to assess the role of LGE in the risk stratification of DCM.RESULTS Nineteen studies involving 7330 patients with DCM were included in this metaanalysis and covered a wide spectrum of DCM,with a mean left ventricular ejection fraction between 21%and 50%.The meta-analysis revealed that the presence of LGE was associated with an increased risk of multiple adverse outcomes(all-cause mortality,HR:2.14;arrhythmic events,HR:5.12;and composite endpoints,HR:2.38;all P<0.001).Furthermore,every 1%increment in the extent of LGE was associated with an increased risk of all-cause mortality.Analysis of a subgroup revealed that the prognostic value varied based on different location and pattern of LGE.Additionally,we found that LGE was a stronger predictor of arrhythmic events in patients with greater left ventricular ejection fraction.CONCLUSION LGE by CMR in patients with DCM exhibited a substantial value in predicting adverse outcomes,and the extent,location,and pattern of LGE could provide additional information for risk stratification.
基金Supported by National Natural Science Foundation of China,No. 81050033Key Projects in the Sichuan Province Science and Technology Pillar Program,No. 2011SZ0237the Science Fund for Distinguished Young Scholars of Sichuan Province,China,No. 2010JQ0039
文摘AIM:To determine whether and how magnetic resonance imaging(MRI)-based total liver volume(TLV) and diffusion weighted imaging(DWI) could predict liver fibrosis.METHODS:Sixteen experimental mature mini-pigs(6 males,10 females),weighing between 20.0 and 24.0 kg were prospectively used to model liver fibrosis induced by intraperitoneal injection of 40% CCl4 dissolved in fat emulsion twice a week for 16 wk,and by feeding 40% CCl4 mixed with maize flour twice daily for the subsequent 5 wk.All the survival animals underwent percutaneous liver biopsy and DWI using b = 300,500 and 800 s/mm2 followed by abdominal gadolinium-enhanced MRI at the 0,5th,9th,16th and 21st weekend after beginning of the modeling.TLV was obtained on enhanced MRI,and apparent diffusion coefficient(ADC) was obtained on DWI.Hepatic tissue specimens were stained with hematoxylin and Masson' s trichrome staining for staging liver fibrosis.Pathological specimens were scored using the human METAVIR classification system.Statistical analyses were performed to determine whether and how the TLV and ADC could be used to predict the stage of liver fibrosis.RESULTS:TLV increased from stage 0 to 2 and decreased from stage 3(r = 0.211;P < 0.001).There was a difference in TLV between stage 0-1 and 2-4(P = 0.03) whereas no difference between stage 0-2 and 3-4(P = 0.71).TLV could predict stage ≥ 2 [area under receiver operating characteristic curve(AUC) = 0.682].There was a decrease in ADC values with increasing stage of fibrosis for b = 300,500 and 800 s/mm2(r =-0.418,-0.535 and-0.622,respectively;all P < 0.001).Differences were found between stage 0-1 and 2-4 in ADC values for b = 300,500 and 800 s/mm2,and between stage 0-2 and 3-4 for b = 500 or 800 s/mm2(all P < 0.05).For predicting stage ≥ 2 and ≥ 3,AUC was 0.803 and 0.847 for b = 500 s/mm2,and 0.848 and 0.887 for b = 800 s/mm2,respectively.CONCLUSION:ADC for b = 500 or 800 s/mm2 could be better than TLV and ADC for b = 300 s/mm2 to pre-dict fibrosis stage ≥ 2 or ≥ 3.
基金the support of the National Natural Science Foundation of China(No.21266016)
文摘The palladium nanoparticles/carbon nanofibers（Pd NPs/CNFs） catalyst was prepared by the electrospinning method, the hydrazine hydrate solution reduction in an ice bath environment, the high temperature carbonization. The catalyst was characterized by X-ray diffraction（XRD）, fieldemission scanning electron microscope（FE-SEM）, and transmission electron microscopy（TEM）. The nanofibers are not cross-linked and arranged in order. The surface of Pd NPs/CNFs is smooth, and it can be observed that a large number of particles were loaded and well-dispersed in carbon fiber matrix, and the particle distribution is uniform. The activity center of catalyst is Pd^（0）. The Pd NPs/CNFs exhibited a high efficiency, good reusability and stability in the Suzuki and Heck reactions. It can be used for at least five consecutive runs without significant loss of its catalytic activity. The good recyclability of Pd NPs/CNFs provides a way to greatly reduce the cost of the catalyst.
基金supported by the National Natural Science Foundation of China(No.21166017)the Research Fund for the Doctoral Program of Higher Education of China(No. 20111514120002)+3 种基金the Natural Science Foundation of Inner Mongolia Autonomous Region(No.2011B50601)Inner Mongolia Autonomous Region's Educational Commission(No.NJZZ11068)the Inner Mongolia Talented People Development Fund,Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region(No.NJYT-12-B13)Program for New Century Excellent Talents in University(NCET-12-1017)
文摘In this work, magnesium tetraphenylporphyrin （MgTPP） was used as a new supramolecular amine-fixing agent. Once introduced, C02 easily competes with MgTPP for amines, leading to the release of MgTPP. The processes can be explained by the fact that the association constant （Kassoc） values of MgTPP with amines were in the range of 0.6 （ethanolamine） to 3.9 （ethylenediamine）, which are lower than the Kassoc values of C02 with these amines. MgTPP interacted with aniline, ethanolamine, pyrrolidine, or ethylenediamine to form 1：1 adducts. Ethylenediamine presents a stronger Kassoc value for MgTPP, so it was considered an optimal agent for C02 capture.
