To the Editor:Sjogren's syndrome (SS)is a multisystem chronic autoimmune disease,and mainly affects the lacrimal and salivary glands,leading to ocular and oral dryness.SS is characterized by a large quantity of au...To the Editor:Sjogren's syndrome (SS)is a multisystem chronic autoimmune disease,and mainly affects the lacrimal and salivary glands,leading to ocular and oral dryness.SS is characterized by a large quantity of autoantibodies and involves multiple systems including the lymphatic system,blood,lungs,kidneys, liver,muscles,and joints.Late complications include interstitial pulmonary fibrosis,peripheral neuropathy,tracheobronchial sicca, blindness,arthralgia,oral candidiasis,and lymphoma.The main histopathological feature of SS is lymphocytic infiltration of the exocrine glands,resulting in acinar cell death,probably through apoptosis.[1]The exact etiology and pathogenesis of SS are still not clear.展开更多
文摘To the Editor:Sjogren's syndrome (SS)is a multisystem chronic autoimmune disease,and mainly affects the lacrimal and salivary glands,leading to ocular and oral dryness.SS is characterized by a large quantity of autoantibodies and involves multiple systems including the lymphatic system,blood,lungs,kidneys, liver,muscles,and joints.Late complications include interstitial pulmonary fibrosis,peripheral neuropathy,tracheobronchial sicca, blindness,arthralgia,oral candidiasis,and lymphoma.The main histopathological feature of SS is lymphocytic infiltration of the exocrine glands,resulting in acinar cell death,probably through apoptosis.[1]The exact etiology and pathogenesis of SS are still not clear.
