Three new homo-adamantanyl type natural products were derived from polyprenylated polycyclic acylphloroglucinol.Hypercohones A-C(1-3),along with five other known hypercohones(4-8),were isolated from the aerial parts o...Three new homo-adamantanyl type natural products were derived from polyprenylated polycyclic acylphloroglucinol.Hypercohones A-C(1-3),along with five other known hypercohones(4-8),were isolated from the aerial parts of Hypericum cohaerens.The structures of 1-3 were elucidated on the basis of comprehensive spectroscopic analysis.The inhibitory activities of these isolates against five human cancer cell lines in vitro were tested.展开更多
BACKGROUND: Several studies have shown that KAI1 inhibits tumor metastasis, but its mechanism is not clear. The present study aimed to determine the role of KAI1 in lymphatic metastasis, specifically in pancreatic can...BACKGROUND: Several studies have shown that KAI1 inhibits tumor metastasis, but its mechanism is not clear. The present study aimed to determine the role of KAI1 in lymphatic metastasis, specifically in pancreatic cancer. METHODS: The KAI1 gene was transfected into the pancreatic cancer cell line MIA PaCa-2 and PANC-1 by using liposomes and selected by G418, and the protein was measured by Western blotting. After successful infection, the cell growth curve was studied by MTT, vascular endothelial growth factor C(VEGF-C) secretion by pancreatic cancer cell were measured by ELISA. The KAI1 and pCMV transfected MIA PaCa-2 cells were renamed as MIA PaCa-2-K and MIA PaCa-2-p. These two kinds of cells were injected into the subcuticular layer of nude mice; both tumor growth and metastasis through the lymphatic nodes were assessed. Lymphangiogenesis in tumors was measured by immunohistochemistry. RESULTS: The VEGF-C secretion was significantly reduced in MIA PaCa-2 cells compared with PANC-1 cells after being transfected with the KAI1 gene. The growth rate of subcutaneous tumors was similar after the injection of MIA PaCa-2-K, MIA PaCa-2, and MIA PaCa-2-p. MIA PaCa-2-K tumors showed slower lymphangiogenesis and lymph node metastasis compared with MIA PaCa-2 and MIA PaCa-2-p tumors. CONCLUSION: The overexpression of KAI1 inhibits the lymphangiogenesis and lymph node metastasis of MIA PaCa-2 pancreatic tumors.展开更多
Two new diterpenoids,salyunnanins I and J(1 and 2),together with ten analogues,were isolated from the roots of Salvia yunnanensis.The structures of the new isolates,possessing different neo-clerodane and seco-abietane...Two new diterpenoids,salyunnanins I and J(1 and 2),together with ten analogues,were isolated from the roots of Salvia yunnanensis.The structures of the new isolates,possessing different neo-clerodane and seco-abietane diterpenoid skeletons respectively,were elucidated on the basis of comprehensive spectroscopic data.All of the compounds were tested for the inhibitory activities against six human tumor lines in vitro,and several ones showed moderate cytotoxic activities.展开更多
BACKGROUND Polyarthritis is the most frequent clinical manifestation in antisynthetase syndrome(ASS)forms of idiopathic inflammatory myositis and may be misdiagnosed as rheumatoid arthritis(RA),particularly in patient...BACKGROUND Polyarthritis is the most frequent clinical manifestation in antisynthetase syndrome(ASS)forms of idiopathic inflammatory myositis and may be misdiagnosed as rheumatoid arthritis(RA),particularly in patients with seronegative RA(SNRA).It is unclear whether there is an overlap between ASS and RA,or if ASS sometimes mimics RA.Pulmonary hypertension(PAH)is common in connective tissue diseases(CTDs).However,published reports on CTD-PAH do not include overlapping CTDs,and its incidence and impact on patient prognosis are unclear.CASE SUMMARY We report the case of a 63-year-old woman who presented with a 3-mo history of symptom aggravation of recurrent symmetrical joint swelling and pain that had persisted for over 10 years.The patient was diagnosed with RA and interstitial lung disease.The patient repeatedly presented to the hospital’s respiratory and rhe-umatology departments with arthralgia,plus shortness of breath after activity.Relevant tests indicated that anti-CCP and RF remained negative,while anti-J0-1 and anti-Ro-52 were strongly positive.It was not until recently that we recognized that this could be an unusual case of SNRA with concurrent ASS.Joint pain was relieved after regular anti-rheumatic treatment.Chest computed tomography scans showed that pulmonary interstitial changes did not progress significantly over several years;however,they showed gradual widening of the pulmonary artery,and cardiac ultrasound indicated elevated pulmonary artery systolic pressure.The prescribed treatment of PAH was not effective in improving shortness of breath.CONCLUSION Overlap of RA and ASS may be missed.Further research is necessary to facilitate early diagnosis,effective evaluation,and prognosis.展开更多
In this study,we report the fabrication of a sensitive deep ultraviolet(DUV)photodetector by using CsPbBr_(3) nanosheets synthesized through confined-space growth at room temperature.The peak pho-toresponse of the dev...In this study,we report the fabrication of a sensitive deep ultraviolet(DUV)photodetector by using CsPbBr_(3) nanosheets synthesized through confined-space growth at room temperature.The peak pho-toresponse of the device upon illumination blueshifts with decreasing thickness and a 68 nm CsPbBr_(3) nanosheet based device displays a peak response to 265 nm illumination,showing responsivity and spe-cific detectivity of 85 mA/W and 4.05×1011 Jones at 3 V bias,respectively.Theoretical simulation re-veals that the blueshift is associated with the wavelength-dependent absorption coefficient of CsPbBr_(3) nanosheet:incident light with shorter wavelengths can be absorbed on the superficial surface,while long-wavelength light has a larger penetration depth,leading to dominant DUV absorption in thinner CsPbBr_(3) nanosheet.This work will shed light on the facile and cost-effective fabrication of DUV photode-tectors from non-ultrawide bandgap(UWBG)all-inorganic perovskite materials.展开更多
有序排列、取向生长的钙钛矿纳米线阵列的合成通常需要复杂的工艺条件和精密的仪器设备,这不利于其广泛应用.本文提出了一种纳米通道限域生长的方法来制备钙钛矿纳米线阵列.利用场发射扫描电子显微镜、原子力显微镜和X射线衍射等分析手...有序排列、取向生长的钙钛矿纳米线阵列的合成通常需要复杂的工艺条件和精密的仪器设备,这不利于其广泛应用.本文提出了一种纳米通道限域生长的方法来制备钙钛矿纳米线阵列.利用场发射扫描电子显微镜、原子力显微镜和X射线衍射等分析手段,表征了纳米线阵列的形貌和晶体结构,证明了该方法可用于在各种衬底上制备大面积的具有取向生长特点的不同种类的钙钛矿纳米线阵列.基于MAPb I3纳米线阵列所制备的光电探测器光响应优异,响应度和比探测率分别为20.56 A W^(-1)和4.73×10^(12)Jones.此外,由于所制备的一维钙钛矿纳米线结构的各向异性,该光电探测器还实现了对于偏振光的探测,其偏振比为2.2.展开更多
Comprehensive Summary The conversion of CF3-alkenes to gem-difluoroalkenes using reductive cross-coupling strategy has received much attention in recent years,however,the use of green and readily available reducing sa...Comprehensive Summary The conversion of CF3-alkenes to gem-difluoroalkenes using reductive cross-coupling strategy has received much attention in recent years,however,the use of green and readily available reducing salt to mediate these reactions remains to be explored.In this work,a concise construction of gem-difluoroalkenes,which requires neither a catalyst nor a metal reducing agent,was established.Rongalite,a safe and inexpensive industrial product,was employed as both a radical initiator and reductant.This procedure was compatible with both linear and cyclic diaryliodonium salts,enabling a wide variety of substrates(>70 examples).The utility of this approach was demonstrated through gram-scale synthesis and efficient late-stage functionalizations of anti-inflammatory drugs.展开更多
基金The work was financially supported by the foundations from NSFC(20972167)the Young Academic Leader Raising Foundation of Yunnan Province(No.2009CI073)the foundation from CAS to Dr Gang Xu.
文摘Three new homo-adamantanyl type natural products were derived from polyprenylated polycyclic acylphloroglucinol.Hypercohones A-C(1-3),along with five other known hypercohones(4-8),were isolated from the aerial parts of Hypericum cohaerens.The structures of 1-3 were elucidated on the basis of comprehensive spectroscopic analysis.The inhibitory activities of these isolates against five human cancer cell lines in vitro were tested.
基金supported by a grant from the National Nature Science Foundation of China(81071982)
文摘BACKGROUND: Several studies have shown that KAI1 inhibits tumor metastasis, but its mechanism is not clear. The present study aimed to determine the role of KAI1 in lymphatic metastasis, specifically in pancreatic cancer. METHODS: The KAI1 gene was transfected into the pancreatic cancer cell line MIA PaCa-2 and PANC-1 by using liposomes and selected by G418, and the protein was measured by Western blotting. After successful infection, the cell growth curve was studied by MTT, vascular endothelial growth factor C(VEGF-C) secretion by pancreatic cancer cell were measured by ELISA. The KAI1 and pCMV transfected MIA PaCa-2 cells were renamed as MIA PaCa-2-K and MIA PaCa-2-p. These two kinds of cells were injected into the subcuticular layer of nude mice; both tumor growth and metastasis through the lymphatic nodes were assessed. Lymphangiogenesis in tumors was measured by immunohistochemistry. RESULTS: The VEGF-C secretion was significantly reduced in MIA PaCa-2 cells compared with PANC-1 cells after being transfected with the KAI1 gene. The growth rate of subcutaneous tumors was similar after the injection of MIA PaCa-2-K, MIA PaCa-2, and MIA PaCa-2-p. MIA PaCa-2-K tumors showed slower lymphangiogenesis and lymph node metastasis compared with MIA PaCa-2 and MIA PaCa-2-p tumors. CONCLUSION: The overexpression of KAI1 inhibits the lymphangiogenesis and lymph node metastasis of MIA PaCa-2 pancreatic tumors.
基金The work was financially supported by the National Natural Sciences Foundation of China(81373291)the National Science and Technology Support Program of China(2013BAI11B02)the foundation from Chinese Academy of Sciences to Dr G.Xu.
文摘Two new diterpenoids,salyunnanins I and J(1 and 2),together with ten analogues,were isolated from the roots of Salvia yunnanensis.The structures of the new isolates,possessing different neo-clerodane and seco-abietane diterpenoid skeletons respectively,were elucidated on the basis of comprehensive spectroscopic data.All of the compounds were tested for the inhibitory activities against six human tumor lines in vitro,and several ones showed moderate cytotoxic activities.
基金Supported by the Natural Science Foundation of China,No.82060010。
文摘BACKGROUND Polyarthritis is the most frequent clinical manifestation in antisynthetase syndrome(ASS)forms of idiopathic inflammatory myositis and may be misdiagnosed as rheumatoid arthritis(RA),particularly in patients with seronegative RA(SNRA).It is unclear whether there is an overlap between ASS and RA,or if ASS sometimes mimics RA.Pulmonary hypertension(PAH)is common in connective tissue diseases(CTDs).However,published reports on CTD-PAH do not include overlapping CTDs,and its incidence and impact on patient prognosis are unclear.CASE SUMMARY We report the case of a 63-year-old woman who presented with a 3-mo history of symptom aggravation of recurrent symmetrical joint swelling and pain that had persisted for over 10 years.The patient was diagnosed with RA and interstitial lung disease.The patient repeatedly presented to the hospital’s respiratory and rhe-umatology departments with arthralgia,plus shortness of breath after activity.Relevant tests indicated that anti-CCP and RF remained negative,while anti-J0-1 and anti-Ro-52 were strongly positive.It was not until recently that we recognized that this could be an unusual case of SNRA with concurrent ASS.Joint pain was relieved after regular anti-rheumatic treatment.Chest computed tomography scans showed that pulmonary interstitial changes did not progress significantly over several years;however,they showed gradual widening of the pulmonary artery,and cardiac ultrasound indicated elevated pulmonary artery systolic pressure.The prescribed treatment of PAH was not effective in improving shortness of breath.CONCLUSION Overlap of RA and ASS may be missed.Further research is necessary to facilitate early diagnosis,effective evaluation,and prognosis.
基金Acknowledgments This research was jointly supported by National Science Foundation of China （No. 20777092）, the ministry of Science and Technology of China （2007CB407304） and Natural science foundation of Zhejiang province of China （Y307025）.
基金the National Natural Science Foundation of China(No.62074048)the Key Research and Development Plan of Anhui Province(No.2022f04020007)+1 种基金the Natural Science Foundation of Anhui Province(No.2208085MF177)the Fundamental Research Funds for the Central Universities(No.PA2020GDKC0014).
文摘In this study,we report the fabrication of a sensitive deep ultraviolet(DUV)photodetector by using CsPbBr_(3) nanosheets synthesized through confined-space growth at room temperature.The peak pho-toresponse of the device upon illumination blueshifts with decreasing thickness and a 68 nm CsPbBr_(3) nanosheet based device displays a peak response to 265 nm illumination,showing responsivity and spe-cific detectivity of 85 mA/W and 4.05×1011 Jones at 3 V bias,respectively.Theoretical simulation re-veals that the blueshift is associated with the wavelength-dependent absorption coefficient of CsPbBr_(3) nanosheet:incident light with shorter wavelengths can be absorbed on the superficial surface,while long-wavelength light has a larger penetration depth,leading to dominant DUV absorption in thinner CsPbBr_(3) nanosheet.This work will shed light on the facile and cost-effective fabrication of DUV photode-tectors from non-ultrawide bandgap(UWBG)all-inorganic perovskite materials.
基金supported by the National Natural Science Foundation of China (NSFC, 62074048)the Fundamental Research Funds for the Central Universities (PA2020GDKC0014, JZ2020HGTB0051, and JZ2018HGXC0001)the Open Foundation of Anhui Provincial Key Laboratory of Advanced Functional Materials and Devices (4500-411104/011)
文摘有序排列、取向生长的钙钛矿纳米线阵列的合成通常需要复杂的工艺条件和精密的仪器设备,这不利于其广泛应用.本文提出了一种纳米通道限域生长的方法来制备钙钛矿纳米线阵列.利用场发射扫描电子显微镜、原子力显微镜和X射线衍射等分析手段,表征了纳米线阵列的形貌和晶体结构,证明了该方法可用于在各种衬底上制备大面积的具有取向生长特点的不同种类的钙钛矿纳米线阵列.基于MAPb I3纳米线阵列所制备的光电探测器光响应优异,响应度和比探测率分别为20.56 A W^(-1)和4.73×10^(12)Jones.此外,由于所制备的一维钙钛矿纳米线结构的各向异性,该光电探测器还实现了对于偏振光的探测,其偏振比为2.2.
基金Project supported by the National Natural Science Foundation of China(Nos.61227801 and 61629101)Huawei Communications Technology Lab,Chinathe Open Research Foundation of Xi’an Jiaotong University,China(No.sklms2015015)
基金supported by the National Natural Science Foundation of China(Grants 21971080,21971079,21772051)This work was also supported by the 111 Project B17019.
文摘Comprehensive Summary The conversion of CF3-alkenes to gem-difluoroalkenes using reductive cross-coupling strategy has received much attention in recent years,however,the use of green and readily available reducing salt to mediate these reactions remains to be explored.In this work,a concise construction of gem-difluoroalkenes,which requires neither a catalyst nor a metal reducing agent,was established.Rongalite,a safe and inexpensive industrial product,was employed as both a radical initiator and reductant.This procedure was compatible with both linear and cyclic diaryliodonium salts,enabling a wide variety of substrates(>70 examples).The utility of this approach was demonstrated through gram-scale synthesis and efficient late-stage functionalizations of anti-inflammatory drugs.
