Recent advances in age-related metabolic dysfunction-associated steatotic liver disease

Metabolic dysfunction-associated steatotic liver disease(MASLD)affects approximately 25%of the world's population and has become a leading cause of chronic liver disease.In recent years,an increasing amount of data suggests that MASLD is associated with aging.As the population ages,age-related MASLD will become a major global health problem.Targeting an aging will become a new approach to the treatment of MASLD.This paper reviews the current studies on the role of aging-related factors and therapeutic targets in MASLD,including:Oxidative stress,autophagy,mitochondrial homeostasis,bile acid metabolism homeostasis,and dysbiosis.The aim is to identify effective therapeutic targets for age-related MASLD and its progression.

Research progress on the mitochondrial mechanism of age-related non-alcoholic fatty liver

Non-alcoholic fatty liver disease(NAFLD)has become the most common chronic liver disease worldwide.Reduced activity and slower metabolism in the elderly affect the balance of lipid metabolism in the liver leading to the accumulation of lipids.This affects the mitochondrial respiratory chain and the efficiency ofβ-oxidation and induces the overproduction of reactive oxygen species.In addition,the dynamic balance of the mitochondria is disrupted during the ageing process,which inhibits its phagocytic function and further aggravates liver injury,leading to a higher incidence of NAFLD in the elderly population.The present study reviewed the manifestations,role and mechanism of mitochondrial dysfunction in the progression of NAFLD in the elderly.Based on the understanding of mitochondrial dysfunction and abnormal lipid metabolism,this study discusses the treatment strategies and the potential therapeutic targets for NAFLD,including lipid accumulation,antioxidation,mitophagy and liver-protecting drugs.The purpose is to provide new ideas for the development of innovative drugs for the prevention and treatment of NAFLD.

Azobenzene Based Photo-responsive Mechanical Actuator Fabricated by Intermolecular H-bond Interaction

Photo-responsive mechanical actuator is a class of stimuli-responsive materials transferring light to mechanical energy through macroscopic transformation.To fabricate photo-responsive mechanical actuator,soft polymeric materials crosslinked with functional bridging structures are desired.Supramolecular interaction is a relatively common way to fabricate crosslinked materials due to its excellent self-assembly performance.And azobenzene and derivatives are ideal candidates of photo-responsive materials because of the unique photo-induced trans-cis isomerization.Here,a new kind of crosslinked materials based on supramolecular interaction between 4,4'-dihydroxyazobenzene and chitosan is reported.Under 355 nm irradiation,the macroscopic bending of polymeric materials occurs rapidly due to the photo-isomerization of 4,4-dihydroxyazobenzene.Meanwhile,the photo-responsive mechanical actuator can also lift weight which is up to 200 times that of the actuator itself,and convert energy from light to mechanical work efficiently.This report suggests a new kind of photo-responsive actuator based on supramolecular interaction and may be helpful to contribute a theoretical basis to the design and synthesis of photo-responsive mechanical actuator suitable for large-scale manufacturing industrialization in future.