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一个中国原发性开角型青光眼家系致病基因研究 被引量:2
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作者 颉娟娟 陈颖 +6 位作者 张国伟 崔海悦 郝梦瑶 王劭雯 贾珍 徐春龙 陆宏 《国际眼科杂志》 CAS 北大核心 2023年第1期175-180,共6页
目的:鉴定一个江苏省南通市原发性开角型青光眼(POAG)家系的青光眼致病基因,分析该基因的临床表型和致病机制。方法:于2020-01/12回顾并招募了一个POAG家系,该家系跨越5代共33名,有13名家庭成员参与了研究,其中4名诊断为POAG,1名诊断为... 目的:鉴定一个江苏省南通市原发性开角型青光眼(POAG)家系的青光眼致病基因,分析该基因的临床表型和致病机制。方法:于2020-01/12回顾并招募了一个POAG家系,该家系跨越5代共33名,有13名家庭成员参与了研究,其中4名诊断为POAG,1名诊断为高眼压症,剩余8名未受影响。详细询问病史并进行全面的眼科检查,采用高通量测序筛选可能的致病基因,Sanger测序验证候选致病基因。结果:该家系患者均在青年时期发现眼压升高并诊断为青光眼,需手术治疗控制眼压,先证者最高眼压(IOP)达55mmHg。全外显子测序在先证者LTBP2基因上发现了一个杂合突变(c.1197C>A,p.Phe399Leu),Sanger测序验证该突变位点与家系疾病并不分离。结论:LTBP2(c.1197C>A)突变不是该家系POAG的致病基因。但是LTBP2突变在POAG病例中的致病作用值得研究。 展开更多
关键词 原发性开角型青光眼 LTBP2基因 基因突变 全外显子测序 遗传
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Application of Space-time Conservation Element and Solution Element Method in Intake and Exhaust Flows of High Power Density Diesel Engine 被引量:2
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作者 Guo-dong YOU chun-long xu +2 位作者 Jun-feng xu Ming ZHU Zeng-quan WANG 《Defence Technology(防务技术)》 SCIE EI CAS 2013年第3期171-175,共5页
A one-dimensional pipe flow model of single-cylinder diesel engine is established to investigate the intake and exhaust flow characteristics of diesel engine in the condition of high power density(HPD).A space-lime co... A one-dimensional pipe flow model of single-cylinder diesel engine is established to investigate the intake and exhaust flow characteristics of diesel engine in the condition of high power density(HPD).A space-lime conservation element and solution element(CE/SE)method is used to derive the discrete equations of the partial differential equation for the intake and exhaust systems.The performance parameters of diesel engine with speed of 2100 r/min are simulated.The simulated results are in accordance with the experimental data.The effect of increased power density on charging coefficient is analyzed using a validated model.The results show that the charging coefficient is slowly improved with the increase in intake pressure,and is obviously reduced with the increase in engine speed. 展开更多
关键词 高功率密度柴油机 时空守恒元 排气流量 柴油发动机 应用 进气压力 偏微分方程 发动机转速
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Effect prediction of stiffened-ring cylindrical shells subjected to drop mass impact 被引量:1
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作者 Sheng-zhuo Lu Jing-xin Ma +3 位作者 Lan Liu chun-long xu Shi-bo Wu Wei-dong Chen 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2022年第2期305-323,共19页
This study focuses on the effect of lateral mass impact on ring-stiffened thin-walled cylindrical shell.Cylindrical shells were fabricated to validate the numerical modeling and analytical techniques,and drop tests we... This study focuses on the effect of lateral mass impact on ring-stiffened thin-walled cylindrical shell.Cylindrical shells were fabricated to validate the numerical modeling and analytical techniques,and drop tests were performed using a rigid spherical indenter.Next,stiffened-ring cylindrical shells with various structural size parameters were simulated using ABAQUS software.The relationships between the impact force,deformation displacement,and rebound velocity were established,on the basis of impact mechanics theory and simulation results.It derived fitting functions to analyse the relationship between the maximum load and maximum displacement of ring-stiffened cylindrical shell under dynamic mass impact.Based on the validation of the simulation model,the fitting function data were compared with the simulation results,and the functions showed a good accuracy.Besides,the parameters,mass ratio and stiffened-ring mass ratio were used to reflect the effect of the mass change in the ring-stiffened cylindrical shell.Furthermore,parametric studies on ring-stiffened cylindrical shell models were conducted to analyse the progressive impact responses. 展开更多
关键词 Drop mass impact Stiffened ring Cylindrical shell Impact load Dynamic response Parametric studies
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