低分子肝素对子宫内膜容受性的作用及其机制研究

目的研究低分子肝素(LMWH)影响子宫内膜容受性的作用机制。方法随机将C57BL/6小鼠分为对照组、造模组、LMWH低剂量造模组和LMWH高剂量造模组。妊娠第5天统计胚胎数量,HE染色对比各组子宫内膜腺体及血管情况,qRT-PCR检测血小板内皮细胞黏附因子1(PECAM1)、同源框基因A10(HOXA10)、WNT7A和β-catenin的mRNA水平。结果LMWH低剂量造模组和LMWH高剂量造模组胚胎数量较造模组增加(P<0.05),LMWH高剂量造模组最高。LMWH高剂量造模组胚胎数量较对照组增加(P<0.05)。LMWH低剂量造模组和LMWH高剂量造模组腺体、血管数量较造模组增加(P<0.05),而LMWH造模组与对照组比较,差异无统计学意义(P>0.05)。LMWH低剂量造模组和LMWH高剂量造模组HOXA10、PECAM1、Wnt7A、β-catenin mRNA相对表达量较造模组增加(P<0.05)。结论LMWH通过Wnt通路提高子宫内膜容受性,其作用机制可能与PECAM1相关。

Compact 2×2 parabolic multimode interference thermo–optic switches based on fluorinated photopolymer

In this work, a dual-side parabolic structural(DSPS) multimode interference(MMI) thermo–optic(TO) waveguide switch is designed and fabricated by using novel low-loss fluorinated photopolymer materials. Comparing with the traditional dual-side linear structural(DSLS) MMI device, the effective length of the MMI coupling region proposed can be effectively reduced by 40%. The thermal stability of the waveguide material is analyzed, and the optical characteristics of the switching chip are simulated. The actual performances of the entire MMI switch are measured with an insertion loss of7 dB, switching power of 15 m W and an extinction ratio of 28 dB. In contrast to the traditional MMI optical switch, the new type of parabolic structural MMI TO waveguide switch exhibits lower power consumption and larger extinction ratio. The compact fluorinated polymer MMI TO switches are suitable well for realizing miniaturization, high-properties, and lower cost of photonic integrated circuits.

Persistent depression is a predictor of quality of life in stroke survivors: results from a 5-year follow-up study of a Chinese cohort

Background:Whether the time course of post-stroke depression (PSD) can be used to predict the quality of life (QoL) of patients with late-stage stroke remains unclear,this study investigated whether persistent depression at 1 year after stroke predicts QoL at 5 years following stroke.Methods:We analyzed the demographic and clinical data of patients with stroke in 56 hospitals across China that participated in the Prospective Cohort Study on the Incidence and Outcome of Patients with PSD in China Study.Follow-up assessments were performed at the following time points after stroke:in person,2 weeks,3 months,6 months,and 1 year;by telephone,5 years.National Institutes of Health Stroke Scale (NIHSS) score on admission,recurrence,disability,depression,QoL,and chronic complications were recorded.Depression was diagnosed using the Diagnostic and Statistical Manual of Mental Disorders.QoL was measured using short form-12 (SF-12).Multivariable ordinal logistic regression analysis was used to identify factors that independently affected the physical component summary (PCS) and mental component summary (MCS) scores of the SF-12.Results:Of the 801 patients evaluated in this study,80 had persistent depression.The multivariable regression analysis of data obtained at 5 years showed that persistent depression at 1 year (odds ratio [OR]:0.48;95% confidence interval [CI]:0.29-0.81) and disability at 5 years (OR:0.34;95% CI:0.23-0.49) were associated with poor MCS scores at 5 years.Old age,a high NIHSS score on admission,disability at 5 years,and stroke recurrence within 5 years were associated with poor PCS scores at the 5-year follow-up.Conclusions:Persistent depression at the 1-year follow-up could predict poor MCS scores at the 5-year follow-up.The development of interventional strategies targeting post-stroke patients with persistent depression is warranted.

Insomnia is associated with increased mortality in patients with first-ever stroke:a 6-year follow-up in a Chinese cohort study

Objective Insomnia is a highly prevalent disorder among patients suffering from stroke.The association between insomnia and stroke mortality is less studied,particularly using the latest diagnostic criteria.The current study examined the relationship between insomnia and mortality among patients with first-evonal hazard models were used to calculate HRs for stroke er stroke in China.Methods Patients with acute cerebrovascular diseases(stroke)were recruited from 56 hospitals in China's Mainland.Insomnia was defined as difficulty falling asleep,or difficulty staying asleep or waking up early,for at least two consecutive visits.Demographic data,medical history and clinical data were collected.Four follow-up visits occurred within the first year after stroke,and the last follow-up call was conducted 6 years later.Cox proportional hazard models were used to calculate HRs for stroke mortality.results Insomnia was reported by 38.4%(489/1273)of patients at baseline.During the 6 years of follow-up,after adjusting for all confounders,insomnia was found to be associated with increased mortality(HR=1.66,95%CI 1.10 to 2.48).Old age(HR=1.08,95%CI 1.06 to 1.10),stroke recurrence in the first year of follow-up(HR=2.53,95%CI 1.48 to 4.31)and stroke survivors with hypertension(HR=1.62,95%CI 1.04 to 2.53)had substantially higher risk of mortality.Conclusions Besides old age,stroke recurrence in the first year of follow-up and hypertension,insomnia is associated with increased risk of mortality in patients with first-ever stroke in China.More studies about prompt and efficient interventions for insomnia are expected in the future.Trial registration number rctn62169508.

Feature matching using quasi-conformal maps

We present a fully automatic method for finding geometrically consistent correspondences while discarding outliers from the candidate point matches in two images. Given a set of candidate matches provided by scale-invariant feature transform(SIFT) descriptors, which may contain many outliers, our goal is to select a subset of these matches retaining much more geometric information constructed by a mapping searched in the space of all diffeomorphisms. This problem can be formulated as a constrained optimization involving both the Beltrami coefficient(BC) term and quasi-conformal map, and solved by an efficient iterative algorithm based on the variable splitting method. In each iteration, we solve two subproblems, namely a linear system and linearly constrained convex quadratic programming. Our algorithm is simple and robust to outliers. We show that our algorithm enables producing more correct correspondences experimentally compared with state-of-the-art approaches.

Prognostic value of admission hyperglycemia on outcomes of thrombolysis in ischemic stroke patients with or without diabetes

Thrombolytic therapy within 4.5 h from symptom onset is a recognized effective and standard therapy for acute ischemic stroke(AIS),but some patients still have a poor clinical outcome.The evaluation and control of predictors for AIS poor clinical outcomes is integral to achieving optimal treatments,but the prognostic value of admission blood glucose(ABG)for this purpose is unclear and still under debate.ABG evaluated in patients without diabetes mellitus(DM)often suggests acute stress hyperglycemia,while ABG may have a close relationship with long-term blood glucose control in patients with DM.However,in most studies about the influence of ABG on the prognosis of recombinant tissue-type plasminogen activator(rtPA)therapy after AIS,patients were not classified into those with and without DM.The present study was designed to investigate the prognostic value of ABG for clinical outcomes of AIS after thrombolysis according to DM status in a Chinese population.

The correlation between white matter hyperintensity and balance disorder and fall risk:An observational, prospective cohort study

Objective: The presence of an association between white matter hyperintensity (WMH) and the risk of falls in older people is uncertain, with little supporting prospective evidence available at present. We aimed to determine whether WMH was associated with dysfunctions of balance and gait, and other sensorimotor factors leading to falls, and the independent factors related to falls in older Chinese people. The protective effect of exercise against falls was also addressed. Methods: In a representative sample of hospital-based individuals aged 50 years and older in China, the patients' history of falls, magnetic resonance imaging data, scores on the 9-item Berg Balance Scale (BBS-9) test and timed up-and-go test (TUGT), and sensorimotor measures of computerized dynamic posturography (CDP) were analyzed. Incident falls were recorded prospectively over a 12-month period. Using regression modeling, the association between the risk of falls and baseline WMH was estimated. Results: Only individuals with severe WMH were at an increased risk of falls, and CDP was more sensitive than BBS-9 in detecting WMH-related balance and gait dysfunction. However, WMH was not an independent predictor of falls. Taller height and overweight or obese body habitus were identified as novel protective factors for falls. Female, fall history, and increased TUGT score were identified as independent risk factors for falls in older Chinese people.

Impact of Libido at 2 Weeks after Stroke on Risk of Stroke Recurrence at 1-Year in a Chinese Stroke Cohort Study

Background： There were few studies on the relation between changes in libido and incidence of stroke recurrence. The aim of this study was to investigate the relationship between libido decrease at 2 weeks after stroke and recurrent stroke at 1-year. Methods： It is a multi-centered, prospective cohort study. The 14th item of the Hamilton Depression Rating Scale-17 was used to evaluate changes of libido in poststroke patients at 2 weeks. Stroke recurrence was defined as an aggravation of former neurological functional deficit, new local or overall symptoms, or stroke diagnosed at re-admission. Results： Among 2341 enrolled patients, 1757 patients had completed follow-up data, 533 （30.34%） patients had decreased libido at 2 weeks, and 166 （9.45%） patients had recurrent stroke at l-year. Multivariate logistic regression analysis showed that, compared with patients with normal libido, the odds ratio （OR） of recurrent stroke in patients with decreased libido was reduced by 4 l% （OR = 0.59, 95% confidence interval [CI]： 0.40-0.87）. The correlation was more prominent among male patients （OR = 0.52, 95% CI： 0.31 0.85） and patients of≥60 years of age （OR = 0.57, 95% CI： 0.35-0.93）. Conclusions： One out of three stroke patients in China's Mainland has decreased libido at 2 weeks after stroke. Decreased libido is a protective factor for stroke recurrence at 1-year, which is more prominent among older male patients.